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DK2042497T3 - Fremgangsmåde til syntese af strontiumranelat og hydrater heraf - Google Patents

Fremgangsmåde til syntese af strontiumranelat og hydrater heraf

Info

Publication number
DK2042497T3
DK2042497T3 DK08290906.0T DK08290906T DK2042497T3 DK 2042497 T3 DK2042497 T3 DK 2042497T3 DK 08290906 T DK08290906 T DK 08290906T DK 2042497 T3 DK2042497 T3 DK 2042497T3
Authority
DK
Denmark
Prior art keywords
hydrates
synthesis
strontium ranelate
ranelate
strontium
Prior art date
Application number
DK08290906.0T
Other languages
English (en)
Inventor
Lucile Vaysse-Ludot
Jean-Pierre Lecouve
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39431194&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2042497(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK2042497T3 publication Critical patent/DK2042497T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
DK08290906.0T 2007-09-26 2008-09-25 Fremgangsmåde til syntese af strontiumranelat og hydrater heraf DK2042497T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0706731A FR2921367B1 (fr) 2007-09-26 2007-09-26 Nouveau procede de synthese du ranelate de strontium et de ses hydrates

Publications (1)

Publication Number Publication Date
DK2042497T3 true DK2042497T3 (da) 2010-06-07

Family

ID=39431194

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08290906.0T DK2042497T3 (da) 2007-09-26 2008-09-25 Fremgangsmåde til syntese af strontiumranelat og hydrater heraf

Country Status (47)

Country Link
US (2) US8063100B2 (da)
EP (1) EP2042497B1 (da)
JP (1) JP5016575B2 (da)
KR (1) KR101099995B1 (da)
CN (1) CN101397292A (da)
AP (1) AP2400A (da)
AR (1) AR068535A1 (da)
AT (1) ATE460408T1 (da)
AU (1) AU2008221618B2 (da)
BR (1) BRPI0803636A2 (da)
CA (1) CA2640041C (da)
CL (1) CL2008002833A1 (da)
CO (1) CO6110143A1 (da)
CR (1) CR10292A (da)
CY (1) CY1110036T1 (da)
DE (1) DE602008000790D1 (da)
DK (1) DK2042497T3 (da)
EA (1) EA014247B1 (da)
EC (1) ECSP088771A (da)
ES (1) ES2342233T3 (da)
FR (1) FR2921367B1 (da)
GE (1) GEP20115191B (da)
GT (1) GT200800190A (da)
HN (1) HN2008001490A (da)
HR (1) HRP20100260T1 (da)
IL (1) IL194089A (da)
JO (1) JO2964B1 (da)
MA (1) MA30319B1 (da)
ME (1) ME01849B (da)
MX (1) MX2008012119A (da)
MY (1) MY144180A (da)
NI (1) NI200800257A (da)
NZ (1) NZ571511A (da)
PA (1) PA8797001A1 (da)
PE (1) PE20090703A1 (da)
PL (1) PL2042497T3 (da)
PT (1) PT2042497E (da)
RS (1) RS51356B (da)
SA (1) SA08290594B1 (da)
SG (1) SG151207A1 (da)
SI (1) SI2042497T1 (da)
SV (1) SV2008003033A (da)
TW (1) TWI358408B (da)
UA (1) UA97638C2 (da)
UY (1) UY31341A1 (da)
WO (1) WO2009074741A2 (da)
ZA (1) ZA200808176B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2921367B1 (fr) * 2007-09-26 2009-10-30 Servier Lab Nouveau procede de synthese du ranelate de strontium et de ses hydrates
EP2346846A1 (en) * 2008-09-29 2011-07-27 Ratiopharm GmbH Anhydrate and hydrate forms of strontium ranelate
HU228820B1 (en) 2010-01-14 2013-05-28 Richter Gedeon Nyrt Process for the preparation of distrontium ranelate
IT1398542B1 (it) * 2010-03-05 2013-03-01 Chemelectiva S R L Processo per la preparazione di un polimorfo
WO2011110597A1 (de) 2010-03-11 2011-09-15 Azad Pharmaceutical Ingredients Ag Verfahren zur herstellung von strontiumranelat
WO2011124992A1 (en) * 2010-03-24 2011-10-13 Actavis Group Ptc Ehf Substantially pure strontium ranelate
US20110275834A1 (en) * 2010-05-06 2011-11-10 Divi's Laboratories, Limited Polymorph of strontium ranelate and a process for its preparation
WO2012046251A2 (en) * 2010-10-08 2012-04-12 Glenmark Generics Limited Novel form of ranelic acid
CZ2011320A3 (cs) * 2011-05-30 2012-12-12 Zentiva, K.S. Stabilní krystalická forma X stroncium ranelátu
CN102391247B (zh) * 2011-09-20 2016-12-28 浙江华海药业股份有限公司 一种雷尼酸锶水合物晶形k及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2651497B1 (fr) * 1989-09-01 1991-10-25 Adir Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
GB2235691A (en) * 1989-09-04 1991-03-13 Du Pont Canada Concentrates of modifying agents in polymers
JP3880262B2 (ja) * 1998-11-02 2007-02-14 株式会社カネカ 水不溶化再生コラーゲン繊維の製造方法
FR2844797B1 (fr) 2002-09-24 2004-10-22 Servier Lab Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844795B1 (fr) * 2002-09-24 2004-10-22 Servier Lab Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
US7138529B2 (en) * 2003-04-16 2006-11-21 Hoffmann-La Roche Inc. Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists
AU2006281157B2 (en) * 2005-08-19 2013-03-28 Glenmark Pharmaceuticals Limited Process for the preparation of strontium ranelate
US20070292529A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating osteoporotic conditions
CN100554263C (zh) * 2006-07-19 2009-10-28 天津药物研究院 雷奈酸锶七水合物的制备方法
FR2921367B1 (fr) * 2007-09-26 2009-10-30 Servier Lab Nouveau procede de synthese du ranelate de strontium et de ses hydrates

Also Published As

Publication number Publication date
AU2008221618A1 (en) 2009-04-09
PE20090703A1 (es) 2009-06-27
KR20090032009A (ko) 2009-03-31
HN2008001490A (es) 2010-10-08
BRPI0803636A2 (pt) 2009-06-02
MX2008012119A (es) 2009-03-25
TW200920743A (en) 2009-05-16
EP2042497B1 (fr) 2010-03-10
JO2964B1 (en) 2016-03-15
AR068535A1 (es) 2009-11-18
WO2009074741A2 (fr) 2009-06-18
US8063100B2 (en) 2011-11-22
AP2400A (en) 2012-04-30
SI2042497T1 (sl) 2010-06-30
RS51356B (en) 2011-02-28
UY31341A1 (es) 2008-10-31
EA200801884A1 (ru) 2009-04-28
CN101397292A (zh) 2009-04-01
GT200800190A (es) 2010-05-21
CL2008002833A1 (es) 2009-08-07
TWI358408B (en) 2012-02-21
PL2042497T3 (pl) 2010-06-30
NI200800257A (es) 2011-01-12
US20120029210A1 (en) 2012-02-02
WO2009074741A3 (fr) 2009-11-26
PT2042497E (pt) 2010-04-28
CR10292A (es) 2008-11-26
MA30319B1 (fr) 2009-04-01
UA97638C2 (ru) 2012-03-12
FR2921367B1 (fr) 2009-10-30
ZA200808176B (en) 2010-02-24
ES2342233T3 (es) 2010-07-02
CO6110143A1 (es) 2009-12-31
GEP20115191B (en) 2011-03-25
HRP20100260T1 (hr) 2010-06-30
PA8797001A1 (es) 2009-09-17
AU2008221618B2 (en) 2012-02-09
MY144180A (en) 2011-08-15
JP5016575B2 (ja) 2012-09-05
SV2008003033A (es) 2010-01-21
SG151207A1 (en) 2009-04-30
EA014247B1 (ru) 2010-10-29
ME01849B (me) 2011-02-28
NZ571511A (en) 2010-01-29
DE602008000790D1 (de) 2010-04-22
ECSP088771A (es) 2009-02-27
SA08290594B1 (ar) 2011-02-23
ATE460408T1 (de) 2010-03-15
EP2042497A1 (fr) 2009-04-01
US20090082578A1 (en) 2009-03-26
IL194089A (en) 2016-04-21
IL194089A0 (en) 2009-11-18
KR101099995B1 (ko) 2011-12-28
CA2640041C (fr) 2011-03-08
CY1110036T1 (el) 2015-01-14
AP2008004617A0 (en) 2008-10-31
JP2009132676A (ja) 2009-06-18
FR2921367A1 (fr) 2009-03-27
CA2640041A1 (fr) 2009-03-26

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