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HK1223353A1 - 受體調節劑 - Google Patents

受體調節劑

Info

Publication number
HK1223353A1
HK1223353A1 HK16111524.4A HK16111524A HK1223353A1 HK 1223353 A1 HK1223353 A1 HK 1223353A1 HK 16111524 A HK16111524 A HK 16111524A HK 1223353 A1 HK1223353 A1 HK 1223353A1
Authority
HK
Hong Kong
Prior art keywords
cxcr7
receptor modulators
modulators
cxcr7 receptor
receptor
Prior art date
Application number
HK16111524.4A
Other languages
English (en)
Inventor
Heinz Fretz
Philippe Guerry
Thierry Kimmerlin
Francois Lehembre
Julien Pothier
Herv Siendt
Anja Valdenaire
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of HK1223353A1 publication Critical patent/HK1223353A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
HK16111524.4A 2013-05-30 2016-10-04 受體調節劑 HK1223353A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2013054478 2013-05-30
PCT/IB2014/061774 WO2014191929A1 (en) 2013-05-30 2014-05-28 Cxcr7 receptor modulators

Publications (1)

Publication Number Publication Date
HK1223353A1 true HK1223353A1 (zh) 2017-07-28

Family

ID=50943357

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16111524.4A HK1223353A1 (zh) 2013-05-30 2016-10-04 受體調節劑

Country Status (31)

Country Link
US (1) US9920010B2 (zh)
EP (1) EP3004082B1 (zh)
JP (1) JP6393749B2 (zh)
KR (1) KR102302580B1 (zh)
CN (1) CN105263924B (zh)
AR (1) AR096490A1 (zh)
AU (1) AU2014272718B2 (zh)
BR (1) BR112015030095B1 (zh)
CA (1) CA2912133C (zh)
CL (1) CL2015003470A1 (zh)
CY (1) CY1119537T1 (zh)
DK (1) DK3004082T3 (zh)
EA (1) EA028604B1 (zh)
ES (1) ES2645470T3 (zh)
HK (1) HK1223353A1 (zh)
HR (1) HRP20171597T1 (zh)
HU (1) HUE036649T2 (zh)
IL (1) IL242782B (zh)
LT (1) LT3004082T (zh)
MA (1) MA38679B1 (zh)
MX (1) MX364104B (zh)
MY (1) MY173564A (zh)
NO (1) NO3004082T3 (zh)
PH (1) PH12015502632A1 (zh)
PL (1) PL3004082T3 (zh)
PT (1) PT3004082T (zh)
SG (1) SG11201509057UA (zh)
SI (1) SI3004082T1 (zh)
TW (1) TWI640510B (zh)
UA (1) UA118562C2 (zh)
WO (1) WO2014191929A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR091516A1 (es) 2012-06-22 2015-02-11 Actelion Pharmaceuticals Ltd Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida
JP6582056B2 (ja) 2014-12-01 2019-09-25 イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd Cxcr7受容体調節剤
WO2017070431A1 (en) * 2015-10-23 2017-04-27 James Merritt Use of ccr1 antagonists as a treatment for tumors of the central nervous system
AU2017302079B2 (en) * 2016-07-28 2021-07-22 Idorsia Pharmaceuticals Ltd Piperidine CXCR7 receptor modulators
LT3625228T (lt) 2017-05-18 2021-10-25 Idorsia Pharmaceuticals Ltd Pirimidino dariniai, kaip pge2 receptoriaus moduliatoriai
HUE056080T2 (hu) 2017-05-18 2022-01-28 Idorsia Pharmaceuticals Ltd Fenilszármazékok mint PGE2 receptor modulátorok
BR112020015024A2 (pt) 2018-01-26 2021-01-19 Idorsia Pharmaceuticals Ltd Forma cristalina, composição farmacêutica, uso de uma forma cristalina, e, método de profilaxia ou tratamento de câncer, distúrbios autoimunes, doenças inflamatórias, rejeição a transplante ou fibrose

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896170A (en) 1969-02-26 1975-07-22 American Home Prod Intermediates for the preparation of 1,3-dihydro-2h-1, -benzodiazepin-2-ones
EP1071426A2 (en) 1998-02-18 2001-01-31 Neurosearch A/S Novel compounds and their use as positive ampa receptor modulators
GB9816984D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
EP1341765A1 (en) 2000-12-07 2003-09-10 AstraZeneca AB Therapeutic compounds
ATE427933T1 (de) * 2002-12-20 2009-04-15 Chemocentryx Inc Inhibitoren der bindungder chemokine i-tac bzw. sdf-1 an den ccxckr2-rezeptor
WO2007059108A2 (en) * 2005-11-10 2007-05-24 Chemocentryx, Inc. Substituted quinolones and methods of use
US20100331298A1 (en) 2007-12-10 2010-12-30 Cytopathfinder, Inc. Carboxamide Compounds and Their Use
AR091516A1 (es) * 2012-06-22 2015-02-11 Actelion Pharmaceuticals Ltd Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida
JP6582056B2 (ja) 2014-12-01 2019-09-25 イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd Cxcr7受容体調節剤

Also Published As

Publication number Publication date
PH12015502632B1 (en) 2016-03-07
EP3004082B1 (en) 2017-08-02
NO3004082T3 (zh) 2017-12-30
NZ715530A (en) 2020-12-18
DK3004082T3 (en) 2017-10-02
IL242782B (en) 2019-06-30
MX364104B (es) 2019-04-12
IL242782A0 (en) 2016-02-01
WO2014191929A1 (en) 2014-12-04
MA38679A1 (fr) 2018-07-31
HUE036649T2 (hu) 2018-07-30
UA118562C2 (uk) 2019-02-11
KR20160013197A (ko) 2016-02-03
PL3004082T3 (pl) 2018-01-31
US9920010B2 (en) 2018-03-20
CA2912133A1 (en) 2014-12-04
CN105263924A (zh) 2016-01-20
MX2015016429A (es) 2016-03-01
CY1119537T1 (el) 2018-03-07
HRP20171597T1 (hr) 2017-12-01
EA201501163A1 (ru) 2016-06-30
TW201529557A (zh) 2015-08-01
US20160107997A1 (en) 2016-04-21
JP2016520120A (ja) 2016-07-11
MY173564A (en) 2020-02-04
CN105263924B (zh) 2018-10-19
CA2912133C (en) 2021-06-22
JP6393749B2 (ja) 2018-09-19
EP3004082A1 (en) 2016-04-13
LT3004082T (lt) 2017-10-25
TWI640510B (zh) 2018-11-11
CL2015003470A1 (es) 2016-06-17
BR112015030095A2 (pt) 2022-07-12
AU2014272718B2 (en) 2018-06-28
AU2014272718A1 (en) 2016-01-21
AR096490A1 (es) 2016-01-13
PT3004082T (pt) 2017-11-13
BR112015030095B1 (pt) 2023-02-28
PH12015502632A1 (en) 2016-03-07
EA028604B1 (ru) 2017-12-29
SG11201509057UA (en) 2015-12-30
MA38679B1 (fr) 2019-12-31
KR102302580B1 (ko) 2021-09-15
ES2645470T3 (es) 2017-12-05
SI3004082T1 (sl) 2017-11-30

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