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MX364104B - Moduladores del receptor cxcr7. - Google Patents

Moduladores del receptor cxcr7.

Info

Publication number
MX364104B
MX364104B MX2015016429A MX2015016429A MX364104B MX 364104 B MX364104 B MX 364104B MX 2015016429 A MX2015016429 A MX 2015016429A MX 2015016429 A MX2015016429 A MX 2015016429A MX 364104 B MX364104 B MX 364104B
Authority
MX
Mexico
Prior art keywords
receptor modulators
cxcr7 receptor
formula
cxcr7
pharmaceuticals
Prior art date
Application number
MX2015016429A
Other languages
English (en)
Other versions
MX2015016429A (es
Inventor
Kimmerlin Thierry
Fretz Heinz
Guerry Philippe
Lehembre Francois
Pothier Julien
Siendt Hervé
Valdenaire Anja
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MX2015016429A publication Critical patent/MX2015016429A/es
Publication of MX364104B publication Critical patent/MX364104B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

La presente invención se relaciona con derivados de Fórmula (I) (ver Fórmula) donde (R1), R2a, R2b, R3a, R3b, R4, L1, L2, X, Y y Ar1 son según lo descrito en la descripción, con su preparación, con sus sales farmacéuticamente aceptables, y con su utilización como productos farmacéuticos, con composiciones farmacéuticas que contienen uno o más compuestos de fórmula (I), y especialmente con su utilización como moduladores del receptor CXCR7.
MX2015016429A 2013-05-30 2014-05-28 Moduladores del receptor cxcr7. MX364104B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2013054478 2013-05-30
PCT/IB2014/061774 WO2014191929A1 (en) 2013-05-30 2014-05-28 Cxcr7 receptor modulators

Publications (2)

Publication Number Publication Date
MX2015016429A MX2015016429A (es) 2016-03-01
MX364104B true MX364104B (es) 2019-04-12

Family

ID=50943357

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015016429A MX364104B (es) 2013-05-30 2014-05-28 Moduladores del receptor cxcr7.

Country Status (31)

Country Link
US (1) US9920010B2 (es)
EP (1) EP3004082B1 (es)
JP (1) JP6393749B2 (es)
KR (1) KR102302580B1 (es)
CN (1) CN105263924B (es)
AR (1) AR096490A1 (es)
AU (1) AU2014272718B2 (es)
BR (1) BR112015030095B1 (es)
CA (1) CA2912133C (es)
CL (1) CL2015003470A1 (es)
CY (1) CY1119537T1 (es)
DK (1) DK3004082T3 (es)
EA (1) EA028604B1 (es)
ES (1) ES2645470T3 (es)
HK (1) HK1223353A1 (es)
HR (1) HRP20171597T1 (es)
HU (1) HUE036649T2 (es)
IL (1) IL242782B (es)
LT (1) LT3004082T (es)
MA (1) MA38679B1 (es)
MX (1) MX364104B (es)
MY (1) MY173564A (es)
NO (1) NO3004082T3 (es)
PH (1) PH12015502632A1 (es)
PL (1) PL3004082T3 (es)
PT (1) PT3004082T (es)
SG (1) SG11201509057UA (es)
SI (1) SI3004082T1 (es)
TW (1) TWI640510B (es)
UA (1) UA118562C2 (es)
WO (1) WO2014191929A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR091516A1 (es) 2012-06-22 2015-02-11 Actelion Pharmaceuticals Ltd Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida
JP6582056B2 (ja) 2014-12-01 2019-09-25 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｃｘｃｒ７受容体調節剤
WO2017070431A1 (en) * 2015-10-23 2017-04-27 James Merritt Use of ccr1 antagonists as a treatment for tumors of the central nervous system
AU2017302079B2 (en) * 2016-07-28 2021-07-22 Idorsia Pharmaceuticals Ltd Piperidine CXCR7 receptor modulators
LT3625228T (lt) 2017-05-18 2021-10-25 Idorsia Pharmaceuticals Ltd Pirimidino dariniai, kaip pge2 receptoriaus moduliatoriai
HUE056080T2 (hu) 2017-05-18 2022-01-28 Idorsia Pharmaceuticals Ltd Fenilszármazékok mint PGE2 receptor modulátorok
BR112020015024A2 (pt) 2018-01-26 2021-01-19 Idorsia Pharmaceuticals Ltd Forma cristalina, composição farmacêutica, uso de uma forma cristalina, e, método de profilaxia ou tratamento de câncer, distúrbios autoimunes, doenças inflamatórias, rejeição a transplante ou fibrose

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896170A (en) 1969-02-26 1975-07-22 American Home Prod Intermediates for the preparation of 1,3-dihydro-2h-1, -benzodiazepin-2-ones
EP1071426A2 (en) 1998-02-18 2001-01-31 Neurosearch A/S Novel compounds and their use as positive ampa receptor modulators
GB9816984D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
EP1341765A1 (en) 2000-12-07 2003-09-10 AstraZeneca AB Therapeutic compounds
ATE427933T1 (de) * 2002-12-20 2009-04-15 Chemocentryx Inc Inhibitoren der bindungder chemokine i-tac bzw. sdf-1 an den ccxckr2-rezeptor
WO2007059108A2 (en) * 2005-11-10 2007-05-24 Chemocentryx, Inc. Substituted quinolones and methods of use
US20100331298A1 (en) 2007-12-10 2010-12-30 Cytopathfinder, Inc. Carboxamide Compounds and Their Use
AR091516A1 (es) * 2012-06-22 2015-02-11 Actelion Pharmaceuticals Ltd Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida
JP6582056B2 (ja) 2014-12-01 2019-09-25 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｃｘｃｒ７受容体調節剤

Also Published As

Publication number Publication date
PH12015502632B1 (en) 2016-03-07
EP3004082B1 (en) 2017-08-02
NO3004082T3 (es) 2017-12-30
NZ715530A (en) 2020-12-18
DK3004082T3 (en) 2017-10-02
IL242782B (en) 2019-06-30
IL242782A0 (en) 2016-02-01
WO2014191929A1 (en) 2014-12-04
MA38679A1 (fr) 2018-07-31
HUE036649T2 (hu) 2018-07-30
UA118562C2 (uk) 2019-02-11
KR20160013197A (ko) 2016-02-03
PL3004082T3 (pl) 2018-01-31
US9920010B2 (en) 2018-03-20
CA2912133A1 (en) 2014-12-04
CN105263924A (zh) 2016-01-20
MX2015016429A (es) 2016-03-01
CY1119537T1 (el) 2018-03-07
HRP20171597T1 (hr) 2017-12-01
EA201501163A1 (ru) 2016-06-30
TW201529557A (zh) 2015-08-01
US20160107997A1 (en) 2016-04-21
JP2016520120A (ja) 2016-07-11
MY173564A (en) 2020-02-04
CN105263924B (zh) 2018-10-19
CA2912133C (en) 2021-06-22
JP6393749B2 (ja) 2018-09-19
EP3004082A1 (en) 2016-04-13
LT3004082T (lt) 2017-10-25
TWI640510B (zh) 2018-11-11
HK1223353A1 (zh) 2017-07-28
CL2015003470A1 (es) 2016-06-17
BR112015030095A2 (pt) 2022-07-12
AU2014272718B2 (en) 2018-06-28
AU2014272718A1 (en) 2016-01-21
AR096490A1 (es) 2016-01-13
PT3004082T (pt) 2017-11-13
BR112015030095B1 (pt) 2023-02-28
PH12015502632A1 (en) 2016-03-07
EA028604B1 (ru) 2017-12-29
SG11201509057UA (en) 2015-12-30
MA38679B1 (fr) 2019-12-31
KR102302580B1 (ko) 2021-09-15
ES2645470T3 (es) 2017-12-05
SI3004082T1 (sl) 2017-11-30

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Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: IDORSIA PHARMACEUTICALS LTD

FG Grant or registration