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HK1220468A1 - 的人抗體 - Google Patents

的人抗體

Info

Publication number
HK1220468A1
HK1220468A1 HK16108450.8A HK16108450A HK1220468A1 HK 1220468 A1 HK1220468 A1 HK 1220468A1 HK 16108450 A HK16108450 A HK 16108450A HK 1220468 A1 HK1220468 A1 HK 1220468A1
Authority
HK
Hong Kong
Prior art keywords
nav17
human antibodies
antibodies
human
Prior art date
Application number
HK16108450.8A
Other languages
English (en)
Inventor
Lynn Macdonald
Andrew J Murphy
Nicholas J Papadopoulos
Neil Stahl
Nicole Alessandri-Haber
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1220468A1 publication Critical patent/HK1220468A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK16108450.8A 2013-03-14 2016-07-18 的人抗體 HK1220468A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361783094P 2013-03-14 2013-03-14
PCT/US2014/024336 WO2014159595A2 (en) 2013-03-14 2014-03-12 Human antibodies to nav1.7

Publications (1)

Publication Number Publication Date
HK1220468A1 true HK1220468A1 (zh) 2017-05-05

Family

ID=50680126

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16108450.8A HK1220468A1 (zh) 2013-03-14 2016-07-18 的人抗體

Country Status (12)

Country Link
US (1) US10072076B2 (zh)
EP (1) EP2970481A2 (zh)
JP (1) JP6533512B2 (zh)
KR (1) KR20150127618A (zh)
CN (1) CN105189553A (zh)
AU (1) AU2014240392A1 (zh)
CA (1) CA2902572A1 (zh)
EA (1) EA201591754A1 (zh)
HK (1) HK1220468A1 (zh)
IL (1) IL240511A0 (zh)
MX (1) MX2015010749A (zh)
WO (1) WO2014159595A2 (zh)

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US8361067B2 (en) 2002-09-30 2013-01-29 Relievant Medsystems, Inc. Methods of therapeutically heating a vertebral body to treat back pain
US6907884B2 (en) 2002-09-30 2005-06-21 Depay Acromed, Inc. Method of straddling an intraosseous nerve
US7258690B2 (en) 2003-03-28 2007-08-21 Relievant Medsystems, Inc. Windowed thermal ablation probe
US10028753B2 (en) 2008-09-26 2018-07-24 Relievant Medsystems, Inc. Spine treatment kits
CA2957010C (en) 2008-09-26 2017-07-04 Relievant Medsystems, Inc. Systems and methods for navigating an instrument through bone
US10390877B2 (en) 2011-12-30 2019-08-27 Relievant Medsystems, Inc. Systems and methods for treating back pain
US10588691B2 (en) 2012-09-12 2020-03-17 Relievant Medsystems, Inc. Radiofrequency ablation of tissue within a vertebral body
AU2013337680B2 (en) 2012-11-05 2019-04-18 Relievant Medsystems, Inc. Systems and methods for creating curved paths through bone and modulating nerves within the bone
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners
EP3046569B1 (en) * 2013-09-16 2020-11-04 Ucl Business Ltd Synergistic combination of analgesic drugs
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
GB201418713D0 (en) 2014-10-21 2014-12-03 Kymab Ltd Bindings Proteins
GB201500464D0 (en) 2015-01-12 2015-02-25 Crescendo Biolog Ltd Method of producing optimised therapeutic molecules
SG11201808821WA (en) 2016-04-18 2018-11-29 Celldex Therapeutics Inc Agonistic antibodies that bind human cd40 and uses thereof
EP3481856A1 (en) 2016-07-06 2019-05-15 Crispr Therapeutics AG Materials and methods for treatment of pain related disorders
CN109843914B (zh) 2016-07-06 2024-03-15 沃泰克斯药物股份有限公司 用于治疗疼痛相关病症的材料和方法
EP3534947A1 (en) 2016-11-03 2019-09-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
GB201711208D0 (en) 2017-07-12 2017-08-23 Iontas Ltd Ion channel inhibitors
WO2019218082A1 (en) * 2018-05-18 2019-11-21 National Research Council Of Canada Antibodies and antibody fragments against hnav1.7 channel and their use in pain and cancer indications
MX2020012678A (es) * 2018-05-31 2021-02-09 Shionogi & Co Anticuerpo monoclonal contra nav1.7.
MX2020013930A (es) * 2018-06-22 2021-03-09 Hoffmann La Roche Oligonucleotidos para modular la expresion del canal de sodio dependiente de voltaje alfa subunidad 9 (scn9a).
CN113473850A (zh) * 2019-02-22 2021-10-01 瑞泽恩制药公司 具有遗传修饰的钠通道的啮齿动物及其使用方法
AU2020346827A1 (en) 2019-09-12 2022-03-31 Relievant Medsystems, Inc. Systems and methods for tissue modulation
AR120817A1 (es) 2019-12-20 2022-03-23 Hoffmann La Roche Oligonucleótidos mejorados para inhibir la expresión de scn9a
CN113318238A (zh) * 2020-02-28 2021-08-31 清华大学 一种抗体药物偶联物及其制备方法和应用
CN113527479B (zh) * 2020-04-17 2022-05-31 易森荟(武汉)生物医药有限公司 特异结合电压门控钠离子通道α亚基Nav1.7的抗体或抗体片段
EP4192864A4 (en) * 2020-08-06 2024-09-04 Stelexis Therapeutics Llc IL-8 ANTIBODIES AND METHODS OF USE THEREOF
US12082876B1 (en) 2020-09-28 2024-09-10 Relievant Medsystems, Inc. Introducer drill
WO2022109102A1 (en) * 2020-11-19 2022-05-27 Merck Sharp & Dohme Corp. Nav1.7 binders
IL303851A (en) 2020-12-22 2023-08-01 Relievant Medsystems Inc Predicting candidates for spinal neuromodulation
WO2023003951A2 (en) * 2021-07-20 2023-01-26 Albert Einstein College Of Medicine Compositions and methods for the treatment of herpes simplex virus infection
KR20240099394A (ko) 2021-11-01 2024-06-28 시오노기세이야쿠가부시키가이샤 신규한 Nav1.7 모노클로날 항체
WO2024225446A1 (ja) * 2023-04-28 2024-10-31 塩野義製薬株式会社 新規なＮａｖ１．７モノクローナル抗体を含む医薬組成物

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US6687362B1 (en) 2000-02-11 2004-02-03 Hallmark Cards, Incorporated Automatic address book update system
CN1203857C (zh) 2000-09-18 2005-06-01 威克斯医药有限公司 局部麻醉与镇痛的新方法
CN1284536C (zh) 2000-09-18 2006-11-15 威克斯医药有限公司 河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用
AU2004299822A1 (en) * 2003-12-12 2005-06-30 Wyeth Novel sodium channel
US7850962B2 (en) 2004-04-20 2010-12-14 Genmab A/S Human monoclonal antibodies against CD20
GB0517487D0 (en) 2005-08-26 2005-10-05 Isis Innovation Antibodies
WO2007109324A2 (en) 2006-03-21 2007-09-27 Xenon Pharmaceuticals, Inc. Potent and selective nav 1.7 sodium channel blockers
EP2041177B1 (en) 2006-06-02 2011-12-14 Regeneron Pharmaceuticals, Inc. High affinity antibodies to human il-6 receptor
WO2011052350A1 (ja) * 2009-10-26 2011-05-05 株式会社クレハ 包装物用切断刃、包装物用切断刃を備えたカートン及び包装物供給体
GB0922434D0 (en) * 2009-12-22 2010-02-03 Ucb Pharma Sa antibodies and fragments thereof
EP2493926B1 (en) 2009-10-27 2020-03-11 UCB Biopharma SRL Function modifying nav 1.7 antibodies
US8871996B2 (en) * 2010-06-09 2014-10-28 Regeneron Pharmaceuticals, Inc. Mice expressing human voltage-gated sodium channels
US8486647B2 (en) 2010-06-09 2013-07-16 Regeneron Pharmaceuticals, Inc. Neuropeptide release assay for sodium channels
PT2631654E (pt) * 2011-05-12 2015-08-21 Regeneron Pharma Ensaio de libertação de neuropéptidos para canais de sódio
US20130115171A1 (en) 2011-11-09 2013-05-09 Stefan I. McDonough Nav1.7-related assays
MY198567A (en) 2012-03-14 2023-09-05 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
GB2517953A (en) 2013-09-05 2015-03-11 Argen X Bv Antibodies to complex targets
JP2016529909A (ja) 2013-09-05 2016-09-29 デューク ユニバーシティ Ｎａｖ１．７抗体及び前記抗体を使用する方法
GB201418713D0 (en) 2014-10-21 2014-12-03 Kymab Ltd Bindings Proteins

Also Published As

Publication number Publication date
MX2015010749A (es) 2015-11-30
US10072076B2 (en) 2018-09-11
CA2902572A1 (en) 2014-10-02
AU2014240392A1 (en) 2015-11-05
EA201591754A1 (ru) 2016-01-29
WO2014159595A2 (en) 2014-10-02
EP2970481A2 (en) 2016-01-20
WO2014159595A3 (en) 2014-12-04
US20160024208A1 (en) 2016-01-28
JP2016512430A (ja) 2016-04-28
CN105189553A (zh) 2015-12-23
JP6533512B2 (ja) 2019-06-19
IL240511A0 (en) 2015-10-29
KR20150127618A (ko) 2015-11-17

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