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HK1219419A1 - 作為 抑制劑的亞氨基噻二嗪二氧化物化合物、組合物及其用途 - Google Patents

作為 抑制劑的亞氨基噻二嗪二氧化物化合物、組合物及其用途

Info

Publication number
HK1219419A1
HK1219419A1 HK16107439.6A HK16107439A HK1219419A1 HK 1219419 A1 HK1219419 A1 HK 1219419A1 HK 16107439 A HK16107439 A HK 16107439A HK 1219419 A1 HK1219419 A1 HK 1219419A1
Authority
HK
Hong Kong
Prior art keywords
bace
compositions
inhibitors
dioxide compounds
iminothiadiazine dioxide
Prior art date
Application number
HK16107439.6A
Other languages
English (en)
Inventor
Jack Scott
Andrew W Stamford
Eric J Gilbert
Jared N Cumming
Ulrich Iserloh
Jeffrey A Misiaszek
Guoqing Li
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43857101&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1219419(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of HK1219419A1 publication Critical patent/HK1219419A1/zh

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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HK16107439.6A 2009-10-08 2016-06-27 作為 抑制劑的亞氨基噻二嗪二氧化物化合物、組合物及其用途 HK1219419A1 (zh)

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US24968509P 2009-10-08 2009-10-08

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HK1219419A1 true HK1219419A1 (zh) 2017-04-07

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HK12108359.4A HK1167608A1 (zh) 2009-10-08 2012-08-27 亞氨基噻二嗪二氧化合物作為β-分泌酶 抑制劑和合成劑，及其用途
HK16107439.6A HK1219419A1 (zh) 2009-10-08 2016-06-27 作為 抑制劑的亞氨基噻二嗪二氧化物化合物、組合物及其用途

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HK12108359.4A HK1167608A1 (zh) 2009-10-08 2012-08-27 亞氨基噻二嗪二氧化合物作為β-分泌酶 抑制劑和合成劑，及其用途

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