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HK1248226A1 - 1,4二取代的咪唑衍生物 - Google Patents

1,4二取代的咪唑衍生物

Info

Publication number
HK1248226A1
HK1248226A1 HK18107692.6A HK18107692A HK1248226A1 HK 1248226 A1 HK1248226 A1 HK 1248226A1 HK 18107692 A HK18107692 A HK 18107692A HK 1248226 A1 HK1248226 A1 HK 1248226A1
Authority
HK
Hong Kong
Prior art keywords
imidazole derivative
substituted imidazole
substituted
derivative
imidazole
Prior art date
Application number
HK18107692.6A
Other languages
English (en)
Inventor
Hitoshi Ban
Manabu Kusagi
Shingo Tojo
Futoshi Hasegawa
Miki Hashizume
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Co Ltd filed Critical Sumitomo Dainippon Pharma Co Ltd
Publication of HK1248226A1 publication Critical patent/HK1248226A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/88Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18107692.6A 2015-06-22 2018-06-14 1,4二取代的咪唑衍生物 HK1248226A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015125174 2015-06-22
JP2015244856 2015-12-16
PCT/JP2016/068423 WO2016208591A1 (ja) 2015-06-22 2016-06-21 1,4-ジ置換イミダゾール誘導体

Publications (1)

Publication Number Publication Date
HK1248226A1 true HK1248226A1 (zh) 2018-10-12

Family

ID=57584875

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18107692.6A HK1248226A1 (zh) 2015-06-22 2018-06-14 1,4二取代的咪唑衍生物

Country Status (13)

Country Link
US (3) US10807945B2 (zh)
EP (1) EP3312170A4 (zh)
JP (1) JP6692354B2 (zh)
KR (1) KR20180028456A (zh)
CN (1) CN107922386B (zh)
AU (1) AU2016284398C1 (zh)
CA (1) CA2990583A1 (zh)
HK (1) HK1248226A1 (zh)
PH (1) PH12017502388A1 (zh)
RU (1) RU2741000C2 (zh)
SG (1) SG11201710695XA (zh)
TW (1) TW201713642A (zh)
WO (1) WO2016208591A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016284398C1 (en) 2015-06-22 2021-01-07 Sumitomo Dainippon Pharma Co., Ltd. 1,4-disubstituted imidazole derivative
US10294237B2 (en) 2015-06-22 2019-05-21 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic heterocyclic amide derivative
US10898469B2 (en) 2016-02-26 2021-01-26 Sumitomo Dainippon Pharma Co., Ltd. Imidazolylamide derivative
JP6775483B2 (ja) * 2016-12-20 2020-10-28 大日本住友製薬株式会社 1,4−ジ置換イミダゾール誘導体からなる医薬
EP3560494A4 (en) * 2016-12-20 2020-08-05 Sumitomo Dainippon Pharma Co., Ltd. MEDICINAL PRODUCT TARGETING A CARCINOUS STEM CELL
US11434472B2 (en) 2016-12-20 2022-09-06 Sumitomo Pharma Co., Ltd. Agent for removing undifferentiated iPS cells
HUE062256T2 (hu) * 2018-03-20 2023-10-28 Sumitomo Pharma Co Ltd Dihidrokromén-származékok
CN112313224B (zh) * 2018-04-06 2024-08-13 阿尔托斯实验室公司 Atf6抑制剂和其用途
JP7287929B2 (ja) * 2019-09-25 2023-06-06 住友ファーマ株式会社 ジヒドロクロメン誘導体を含有する医薬

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5359664A (en) 1976-11-10 1978-05-29 Sumitomo Chem Co Ltd Novel imidazole derivatives
US4140788A (en) 1976-11-10 1979-02-20 Sumitomo Chemical Company, Limited N-Substituted imidazolecarboxamide derivatives
JPH11513382A (ja) * 1995-10-20 1999-11-16 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング 5員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
KR20010021905A (ko) 1997-07-15 2001-03-15 노미야마 아키히콰 신규인 푸린유도체 및 그 의약용도
EP1730119B1 (en) * 2004-03-23 2008-06-25 Pfizer Products Incorporated Imidazole compounds for the treatment of neurodegenerative disorders
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
CA2597896A1 (en) * 2005-02-16 2006-08-24 Solvay Pharmaceuticals B.V. 1h-imidazole derivatives as cannabinoid cb2 receptor modulators
AR052666A1 (es) * 2005-02-16 2007-03-28 Solvay Pharm Bv Derivados de 1h-imidazol como moduladores del receptor cannabinoide cb2
DE102005008183A1 (de) 2005-02-23 2006-08-31 Bayer Healthcare Ag Heterocyclylamid-substituierte Imidazole
GB0508472D0 (en) * 2005-04-26 2005-06-01 Glaxo Group Ltd Compounds
BRPI0620373A2 (pt) 2005-12-23 2011-11-08 Astrazeneca Ab composto e sais farmaceuticamente e farmacologicamente aceitáveis dos mesmos, e enantiÈmeros do composto e sais dos mesmos, uso dos mesmos, opcionalmente em combinação com um agonista do receptor de gabab,e , composição farmaceutica
WO2008073461A2 (en) 2006-12-11 2008-06-19 Wyeth Ion channel modulators
GB0722075D0 (en) * 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
LT2688885T (lt) * 2011-03-22 2016-09-12 Bayer Intellectual Property Gmbh N-(1,3,4-oksadiazol-2-il)arilkarboksamidai ir jų panaudojimas kaip herbicidų
IN2014CN02949A (zh) * 2011-10-18 2015-07-03 Astellas Pharma Inc
CN106459071A (zh) 2014-03-31 2017-02-22 波士顿生物技术公司 新的三环醌衍生物
GB201416754D0 (en) * 2014-09-23 2014-11-05 Mission Therapeutics Ltd Novel compounds
AU2016284398C1 (en) * 2015-06-22 2021-01-07 Sumitomo Dainippon Pharma Co., Ltd. 1,4-disubstituted imidazole derivative

Also Published As

Publication number Publication date
US20180230085A1 (en) 2018-08-16
TW201713642A (zh) 2017-04-16
EP3312170A4 (en) 2018-12-12
RU2018102087A (ru) 2019-07-23
AU2016284398A1 (en) 2018-02-01
PH12017502388A1 (en) 2018-07-09
CA2990583A1 (en) 2016-12-29
JPWO2016208591A1 (ja) 2018-04-05
RU2018102087A3 (zh) 2019-12-25
CN107922386B (zh) 2021-04-02
KR20180028456A (ko) 2018-03-16
CN107922386A (zh) 2018-04-17
US20170166552A1 (en) 2017-06-15
RU2741000C2 (ru) 2021-01-22
SG11201710695XA (en) 2018-01-30
US9828362B2 (en) 2017-11-28
EP3312170A1 (en) 2018-04-25
AU2016284398B2 (en) 2020-08-06
US10807945B2 (en) 2020-10-20
US20210171440A1 (en) 2021-06-10
US11661397B2 (en) 2023-05-30
WO2016208591A1 (ja) 2016-12-29
AU2016284398C1 (en) 2021-01-07
JP6692354B2 (ja) 2020-05-13

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