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HK1189223A1 - 用作β分泌酶 抑制劑的 -二氫-吡咯並 吡嗪- -基胺衍生物 - Google Patents

用作β分泌酶 抑制劑的 -二氫-吡咯並 吡嗪- -基胺衍生物

Info

Publication number
HK1189223A1
HK1189223A1 HK14102159.7A HK14102159A HK1189223A1 HK 1189223 A1 HK1189223 A1 HK 1189223A1 HK 14102159 A HK14102159 A HK 14102159A HK 1189223 A1 HK1189223 A1 HK 1189223A1
Authority
HK
Hong Kong
Prior art keywords
bace
betasecretase
pyrazin
pyrrolo
dihydro
Prior art date
Application number
HK14102159.7A
Other languages
English (en)
Inventor
Andrs Avelino Trabanco-Surez
Francisca Delgado-Jimnez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1189223A1 publication Critical patent/HK1189223A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK14102159.7A 2011-03-09 2014-03-04 用作β分泌酶 抑制劑的 -二氫-吡咯並 吡嗪- -基胺衍生物 HK1189223A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11157418 2011-03-09
PCT/EP2012/053863 WO2012120023A1 (en) 2011-03-09 2012-03-07 3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

Publications (1)

Publication Number Publication Date
HK1189223A1 true HK1189223A1 (zh) 2014-05-30

Family

ID=43833325

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14102159.7A HK1189223A1 (zh) 2011-03-09 2014-03-04 用作β分泌酶 抑制劑的 -二氫-吡咯並 吡嗪- -基胺衍生物

Country Status (20)

Country Link
US (1) US9845326B2 (zh)
EP (1) EP2683721B1 (zh)
JP (1) JP5853035B2 (zh)
KR (1) KR102012675B1 (zh)
CN (1) CN103415521B (zh)
AU (1) AU2012224632B2 (zh)
BR (1) BR112013022917A2 (zh)
CA (1) CA2825620C (zh)
CL (1) CL2013002511A1 (zh)
CO (1) CO6751283A2 (zh)
EA (1) EA023824B1 (zh)
ES (1) ES2534973T3 (zh)
HK (1) HK1189223A1 (zh)
IL (1) IL228239A (zh)
MX (1) MX340031B (zh)
MY (1) MY163346A (zh)
SG (1) SG193342A1 (zh)
UA (1) UA109687C2 (zh)
WO (1) WO2012120023A1 (zh)
ZA (1) ZA201306719B (zh)

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RU2572076C2 (ru) * 2014-03-26 2015-12-27 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" 1-арилпирроло[1,2-a]пиразин-3-карбоксамиды с нейропсихотропной активностью
EP3233834B1 (en) 2014-12-18 2019-11-13 Janssen Pharmaceutica NV 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine derivatives useful as inhibitors of beta-secretase
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Also Published As

Publication number Publication date
CL2013002511A1 (es) 2014-01-24
KR20140019332A (ko) 2014-02-14
JP2014507455A (ja) 2014-03-27
KR102012675B1 (ko) 2019-08-21
IL228239A (en) 2016-06-30
EP2683721B1 (en) 2015-01-28
MX2013010280A (es) 2013-10-01
ES2534973T3 (es) 2015-04-30
ZA201306719B (en) 2015-04-29
MX340031B (es) 2016-06-21
UA109687C2 (xx) 2015-09-25
BR112013022917A2 (pt) 2016-12-06
IL228239A0 (en) 2013-11-25
CN103415521B (zh) 2016-01-06
JP5853035B2 (ja) 2016-02-09
EA201391296A1 (ru) 2014-01-30
US9845326B2 (en) 2017-12-19
EP2683721A1 (en) 2014-01-15
CA2825620C (en) 2019-04-23
CA2825620A1 (en) 2012-09-13
US20130345228A1 (en) 2013-12-26
WO2012120023A1 (en) 2012-09-13
CO6751283A2 (es) 2013-09-16
NZ615720A (en) 2014-08-29
AU2012224632A1 (en) 2013-08-01
AU2012224632B2 (en) 2016-06-16
MY163346A (en) 2017-09-15
EA023824B1 (ru) 2016-07-29
SG193342A1 (en) 2013-10-30
CN103415521A (zh) 2013-11-27

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230305