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HK1177434A1 - J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen j591 - Google Patents

J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen j591

Info

Publication number
HK1177434A1
HK1177434A1 HK13104644.7A HK13104644A HK1177434A1 HK 1177434 A1 HK1177434 A1 HK 1177434A1 HK 13104644 A HK13104644 A HK 13104644A HK 1177434 A1 HK1177434 A1 HK 1177434A1
Authority
HK
Hong Kong
Prior art keywords
minibodies
diabodies
cys
human prostate
prostate specific
Prior art date
Application number
HK13104644.7A
Other languages
English (en)
Chinese (zh)
Inventor
．何
．奧拉夫森
．李普曼
Original Assignee
伊麥吉納博公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 伊麥吉納博公司 filed Critical 伊麥吉納博公司
Publication of HK1177434A1 publication Critical patent/HK1177434A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK13104644.7A 2009-12-02 2013-04-17 J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen j591 HK1177434A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26613409P 2009-12-02 2009-12-02
PCT/US2010/058803 WO2011069019A2 (en) 2009-12-02 2010-12-02 J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use

Publications (1)

Publication Number Publication Date
HK1177434A1 true HK1177434A1 (en) 2013-08-23

Family

ID=44115507

Family Applications (2)

Application Number Title Priority Date Filing Date
HK13104644.7A HK1177434A1 (en) 2009-12-02 2013-04-17 J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen j591
HK16105933.1A HK1217957A1 (zh) 2009-12-02 2016-05-24 靶向人前列腺特異性膜抗原的 微抗體和雙抗體

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK16105933.1A HK1217957A1 (zh) 2009-12-02 2016-05-24 靶向人前列腺特異性膜抗原的 微抗體和雙抗體

Country Status (12)

Country Link
US (4) US8772459B2 (xx)
EP (3) EP2506876B1 (xx)
JP (2) JP6251477B2 (xx)
CN (2) CN105085681B (xx)
AU (1) AU2010325969B2 (xx)
BR (1) BR112012012887A2 (xx)
CA (2) CA2782333C (xx)
HK (2) HK1177434A1 (xx)
MX (2) MX337600B (xx)
RU (1) RU2673908C2 (xx)
WO (1) WO2011069019A2 (xx)
ZA (1) ZA201204855B (xx)

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CN105085681A (zh) 2015-11-25
WO2011069019A3 (en) 2012-07-05
BR112012012887A2 (pt) 2017-05-02
US20140234215A1 (en) 2014-08-21
CA2782333A1 (en) 2011-06-09
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MX2012006301A (es) 2012-09-07
CN102753194B (zh) 2015-07-08
JP6251477B2 (ja) 2017-12-20
RU2012123550A (ru) 2014-01-10
AU2010325969A1 (en) 2012-06-21
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US11180570B2 (en) 2021-11-23
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CA2782333C (en) 2019-06-04
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ZA201204855B (en) 2013-03-27
US8772459B2 (en) 2014-07-08
EP2506876B1 (en) 2016-10-12
HK1217957A1 (zh) 2017-01-27
WO2011069019A2 (en) 2011-06-09
US20110268656A1 (en) 2011-11-03
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AU2010325969B2 (en) 2016-10-20
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