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HK1169397A1 - Imidazole derivatives as mglur5 antagonists mglur5 - Google Patents

Imidazole derivatives as mglur5 antagonists mglur5

Info

Publication number
HK1169397A1
HK1169397A1 HK12110080.6A HK12110080A HK1169397A1 HK 1169397 A1 HK1169397 A1 HK 1169397A1 HK 12110080 A HK12110080 A HK 12110080A HK 1169397 A1 HK1169397 A1 HK 1169397A1
Authority
HK
Hong Kong
Prior art keywords
mglur5
antagonists
imidazole derivatives
imidazole
derivatives
Prior art date
Application number
HK12110080.6A
Other languages
English (en)
Chinese (zh)
Inventor
喬治.耶施克
洛塔爾.林德曼
埃里克.維埃拉
於爾根.維希曼
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42358156&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1169397(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1169397A1 publication Critical patent/HK1169397A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK12110080.6A 2009-07-17 2012-10-12 Imidazole derivatives as mglur5 antagonists mglur5 HK1169397A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09165780 2009-07-17
PCT/EP2010/060097 WO2011006910A1 (en) 2009-07-17 2010-07-14 Imidazole derivatives as mglur5 antagonists

Publications (1)

Publication Number Publication Date
HK1169397A1 true HK1169397A1 (en) 2013-01-25

Family

ID=42358156

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12110080.6A HK1169397A1 (en) 2009-07-17 2012-10-12 Imidazole derivatives as mglur5 antagonists mglur5

Country Status (34)

Country Link
US (1) US8334287B2 (da)
EP (1) EP2456765B1 (da)
JP (1) JP5667182B2 (da)
KR (1) KR101431347B1 (da)
CN (1) CN102471309B (da)
AR (1) AR077481A1 (da)
AU (1) AU2010272585B2 (da)
BR (1) BR112012001092A2 (da)
CA (1) CA2765921C (da)
CL (1) CL2012000102A1 (da)
CO (1) CO6400142A2 (da)
CR (1) CR20110659A (da)
CY (1) CY1114186T1 (da)
DK (1) DK2456765T3 (da)
EC (1) ECSP12011611A (da)
ES (1) ES2411467T3 (da)
HK (1) HK1169397A1 (da)
HR (1) HRP20130657T1 (da)
IL (1) IL216746A (da)
MA (1) MA33386B1 (da)
MX (1) MX2012000814A (da)
MY (1) MY156878A (da)
NZ (1) NZ596810A (da)
PE (1) PE20120397A1 (da)
PL (1) PL2456765T3 (da)
PT (1) PT2456765E (da)
RS (1) RS52901B (da)
RU (1) RU2527106C2 (da)
SG (1) SG178052A1 (da)
SI (1) SI2456765T1 (da)
TW (1) TWI423964B (da)
UA (1) UA107086C2 (da)
WO (1) WO2011006910A1 (da)
ZA (1) ZA201109451B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA113223C2 (xx) * 2012-08-13 2016-12-26 Арилетинілпіримідини
WO2015143164A1 (en) * 2014-03-19 2015-09-24 President And Fellows Of Harvard College Antimicrobial agents and screening methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001522357A (ja) * 1997-04-24 2001-11-13 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 炎症性疾患の治療に有用な置換イミダゾール
ES2248410T3 (es) 2000-12-04 2006-03-16 F. Hoffmann-La Roche Ag Derivados de feniletenil o feniletinil como antagonistas receptores de glutamato.
GB0128996D0 (en) 2001-12-04 2002-01-23 Novartis Ag Organic compounds
TWI292318B (en) * 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
RU2327697C2 (ru) * 2003-06-12 2008-06-27 Ф.Хоффманн-Ля Рош Аг Гетероарилзамещенные производные имидазола в качестве антагонистов глутаматных рецепторов
US7452909B2 (en) * 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
ATE397601T1 (de) 2004-06-01 2008-06-15 Hoffmann La Roche Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors
ES2307182T3 (es) * 2004-06-01 2008-11-16 F. Hoffmann-La Roche Ag Piridin-4-il-etinil-imidazoles y pirazoles como antagonistas receptores de mglur5.
JP2010510314A (ja) 2006-11-22 2010-04-02 シーサイド セラピューティクス,エルエルシー 精神遅滞、ダウン症候群、脆弱x症候群および自閉症の治療方法

Also Published As

Publication number Publication date
PE20120397A1 (es) 2012-04-24
RS52901B (en) 2014-02-28
RU2012104399A (ru) 2013-08-27
JP5667182B2 (ja) 2015-02-12
ECSP12011611A (es) 2012-02-29
CR20110659A (es) 2012-03-02
PL2456765T3 (pl) 2013-09-30
KR101431347B1 (ko) 2014-08-19
AR077481A1 (es) 2011-08-31
TWI423964B (zh) 2014-01-21
ES2411467T3 (es) 2013-07-05
SG178052A1 (en) 2012-03-29
US20110015202A1 (en) 2011-01-20
ZA201109451B (en) 2012-08-29
CY1114186T1 (el) 2016-08-31
MX2012000814A (es) 2012-03-14
IL216746A (en) 2015-03-31
CA2765921A1 (en) 2011-01-20
CN102471309A (zh) 2012-05-23
CN102471309B (zh) 2014-09-03
UA107086C2 (ru) 2014-11-25
EP2456765B1 (en) 2013-05-01
US8334287B2 (en) 2012-12-18
JP2012532913A (ja) 2012-12-20
WO2011006910A1 (en) 2011-01-20
MA33386B1 (fr) 2012-06-01
EP2456765A1 (en) 2012-05-30
IL216746A0 (en) 2012-03-01
TW201116523A (en) 2011-05-16
AU2010272585B2 (en) 2013-11-07
PT2456765E (pt) 2013-06-20
DK2456765T3 (da) 2013-05-27
KR20120032033A (ko) 2012-04-04
CL2012000102A1 (es) 2012-09-07
MY156878A (en) 2016-04-15
RU2527106C2 (ru) 2014-08-27
HRP20130657T1 (en) 2013-08-31
NZ596810A (en) 2014-01-31
SI2456765T1 (sl) 2013-06-28
BR112012001092A2 (pt) 2020-08-25
AU2010272585A1 (en) 2012-01-19
CO6400142A2 (es) 2012-03-15
CA2765921C (en) 2017-04-18

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