DK2456765T3 - Imidazolderivater som mglur5-antagonister - Google Patents
Imidazolderivater som mglur5-antagonisterInfo
- Publication number
- DK2456765T3 DK2456765T3 DK10730192.1T DK10730192T DK2456765T3 DK 2456765 T3 DK2456765 T3 DK 2456765T3 DK 10730192 T DK10730192 T DK 10730192T DK 2456765 T3 DK2456765 T3 DK 2456765T3
- Authority
- DK
- Denmark
- Prior art keywords
- mglur5 antagonists
- imidazold
- derivatives
- imidazold derivatives
- mglur5
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09165780 | 2009-07-17 | ||
PCT/EP2010/060097 WO2011006910A1 (en) | 2009-07-17 | 2010-07-14 | Imidazole derivatives as mglur5 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2456765T3 true DK2456765T3 (da) | 2013-05-27 |
Family
ID=42358156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10730192.1T DK2456765T3 (da) | 2009-07-17 | 2010-07-14 | Imidazolderivater som mglur5-antagonister |
Country Status (34)
Country | Link |
---|---|
US (1) | US8334287B2 (da) |
EP (1) | EP2456765B1 (da) |
JP (1) | JP5667182B2 (da) |
KR (1) | KR101431347B1 (da) |
CN (1) | CN102471309B (da) |
AR (1) | AR077481A1 (da) |
AU (1) | AU2010272585B2 (da) |
BR (1) | BR112012001092A2 (da) |
CA (1) | CA2765921C (da) |
CL (1) | CL2012000102A1 (da) |
CO (1) | CO6400142A2 (da) |
CR (1) | CR20110659A (da) |
CY (1) | CY1114186T1 (da) |
DK (1) | DK2456765T3 (da) |
EC (1) | ECSP12011611A (da) |
ES (1) | ES2411467T3 (da) |
HK (1) | HK1169397A1 (da) |
HR (1) | HRP20130657T1 (da) |
IL (1) | IL216746A (da) |
MA (1) | MA33386B1 (da) |
MX (1) | MX2012000814A (da) |
MY (1) | MY156878A (da) |
NZ (1) | NZ596810A (da) |
PE (1) | PE20120397A1 (da) |
PL (1) | PL2456765T3 (da) |
PT (1) | PT2456765E (da) |
RS (1) | RS52901B (da) |
RU (1) | RU2527106C2 (da) |
SG (1) | SG178052A1 (da) |
SI (1) | SI2456765T1 (da) |
TW (1) | TWI423964B (da) |
UA (1) | UA107086C2 (da) |
WO (1) | WO2011006910A1 (da) |
ZA (1) | ZA201109451B (da) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
WO2015143164A1 (en) * | 2014-03-19 | 2015-09-24 | President And Fellows Of Harvard College | Antimicrobial agents and screening methods |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1028954T3 (da) * | 1997-04-24 | 2003-10-27 | Ortho Mcneil Pharm Inc | Substituerede imidazoler egnede til behandling af inflammatoriske sygdomme |
SI1349839T1 (da) | 2000-12-04 | 2005-08-31 | Hoffmann La Roche | |
GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
TWI292318B (en) * | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
BRPI0411350A (pt) * | 2003-06-12 | 2006-07-11 | Hoffmann La Roche | derivados de imidazol substituìdos por heteroarilas como antagonistas de receptores de glutamato |
US7452909B2 (en) * | 2003-09-04 | 2008-11-18 | Hoffman-La Roche Inc. | Imidazole derivatives |
PT1756086E (pt) * | 2004-06-01 | 2008-08-08 | Hoffmann La Roche | Piridin-4-il-etinil-imidazoles e pirazoles como antagonistas dos receptores mglu5 |
ATE397601T1 (de) | 2004-06-01 | 2008-06-15 | Hoffmann La Roche | Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors |
HUE032743T2 (en) | 2006-11-22 | 2017-10-30 | Clinical Res Ass Llc | A method for treating Down syndrome, fragilis X syndrome and autism |
-
2010
- 2010-07-09 US US12/833,017 patent/US8334287B2/en active Active
- 2010-07-14 BR BR112012001092-1A patent/BR112012001092A2/pt not_active Application Discontinuation
- 2010-07-14 EP EP10730192.1A patent/EP2456765B1/en active Active
- 2010-07-14 PE PE2012000035A patent/PE20120397A1/es not_active Application Discontinuation
- 2010-07-14 RU RU2012104399/04A patent/RU2527106C2/ru not_active IP Right Cessation
- 2010-07-14 SG SG2012003661A patent/SG178052A1/en unknown
- 2010-07-14 DK DK10730192.1T patent/DK2456765T3/da active
- 2010-07-14 CA CA2765921A patent/CA2765921C/en not_active Expired - Fee Related
- 2010-07-14 PT PT107301921T patent/PT2456765E/pt unknown
- 2010-07-14 SI SI201030209T patent/SI2456765T1/sl unknown
- 2010-07-14 UA UAA201201027A patent/UA107086C2/ru unknown
- 2010-07-14 CN CN201080031886.6A patent/CN102471309B/zh active Active
- 2010-07-14 KR KR1020127004121A patent/KR101431347B1/ko active IP Right Grant
- 2010-07-14 NZ NZ596810A patent/NZ596810A/en not_active IP Right Cessation
- 2010-07-14 MX MX2012000814A patent/MX2012000814A/es active IP Right Grant
- 2010-07-14 ES ES10730192T patent/ES2411467T3/es active Active
- 2010-07-14 RS RS20130331A patent/RS52901B/en unknown
- 2010-07-14 PL PL10730192T patent/PL2456765T3/pl unknown
- 2010-07-14 TW TW099123206A patent/TWI423964B/zh not_active IP Right Cessation
- 2010-07-14 MY MYPI2012000151A patent/MY156878A/en unknown
- 2010-07-14 MA MA34494A patent/MA33386B1/fr unknown
- 2010-07-14 WO PCT/EP2010/060097 patent/WO2011006910A1/en active Application Filing
- 2010-07-14 JP JP2012520013A patent/JP5667182B2/ja active Active
- 2010-07-14 AU AU2010272585A patent/AU2010272585B2/en not_active Ceased
- 2010-07-15 AR ARP100102580A patent/AR077481A1/es unknown
-
2011
- 2011-11-29 CO CO11164352A patent/CO6400142A2/es active IP Right Grant
- 2011-12-01 IL IL216746A patent/IL216746A/en not_active IP Right Cessation
- 2011-12-08 CR CR20110659A patent/CR20110659A/es unknown
- 2011-12-21 ZA ZA2011/09451A patent/ZA201109451B/en unknown
-
2012
- 2012-01-13 CL CL2012000102A patent/CL2012000102A1/es unknown
- 2012-01-17 EC EC2012011611A patent/ECSP12011611A/es unknown
- 2012-10-12 HK HK12110080.6A patent/HK1169397A1/xx unknown
-
2013
- 2013-07-10 HR HRP20130657AT patent/HRP20130657T1/hr unknown
- 2013-07-22 CY CY20131100614T patent/CY1114186T1/el unknown
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