HK1149721A1 - 基於血管緊張素受體拮抗劑/阻斷劑 及中性內肽酶 抑制劑的超結構的雙向作用藥物組合物 - Google Patents
基於血管緊張素受體拮抗劑/阻斷劑 及中性內肽酶 抑制劑的超結構的雙向作用藥物組合物Info
- Publication number
- HK1149721A1 HK1149721A1 HK11107642.4A HK11107642A HK1149721A1 HK 1149721 A1 HK1149721 A1 HK 1149721A1 HK 11107642 A HK11107642 A HK 11107642A HK 1149721 A1 HK1149721 A1 HK 1149721A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- arb
- nep
- superstructures
- blocker
- inhibitor
- Prior art date
Links
- 102000003729 Neprilysin Human genes 0.000 title 1
- 108090000028 Neprilysin Proteins 0.000 title 1
- 229940127282 angiotensin receptor antagonist Drugs 0.000 title 1
- 229940125364 angiotensin receptor blocker Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98566807P | 2007-11-06 | 2007-11-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1149721A1 true HK1149721A1 (zh) | 2011-10-14 |
Family
ID=40451030
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11107642.4A HK1149721A1 (zh) | 2007-11-06 | 2010-10-19 | 基於血管緊張素受體拮抗劑/阻斷劑 及中性內肽酶 抑制劑的超結構的雙向作用藥物組合物 |
HK10109891.9A HK1143529A1 (zh) | 2007-11-06 | 2010-10-19 | 基於血管緊張素受體拮抗劑/阻斷劑 及中性內肽酶 抑制劑的超結構的雙向作用藥物組合物 |
HK16112495.7A HK1224195A1 (zh) | 2007-11-06 | 2016-10-31 | 基於血管緊張素受體拮抗劑/阻斷劑 及中性內肽酶 抑制劑的超結構的藥物組合物 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10109891.9A HK1143529A1 (zh) | 2007-11-06 | 2010-10-19 | 基於血管緊張素受體拮抗劑/阻斷劑 及中性內肽酶 抑制劑的超結構的雙向作用藥物組合物 |
HK16112495.7A HK1224195A1 (zh) | 2007-11-06 | 2016-10-31 | 基於血管緊張素受體拮抗劑/阻斷劑 及中性內肽酶 抑制劑的超結構的藥物組合物 |
Country Status (34)
Country | Link |
---|---|
US (3) | US20100267786A1 (zh) |
EP (4) | EP4186491A1 (zh) |
JP (2) | JP5653218B2 (zh) |
KR (2) | KR101700062B1 (zh) |
CN (2) | CN101848700A (zh) |
AR (1) | AR069184A1 (zh) |
AU (1) | AU2008324878B2 (zh) |
BR (1) | BRPI0823505A2 (zh) |
CA (1) | CA2703598C (zh) |
CL (1) | CL2008003298A1 (zh) |
CY (2) | CY1116280T1 (zh) |
DK (3) | DK3067043T3 (zh) |
EC (1) | ECSP10010160A (zh) |
ES (3) | ES2587336T3 (zh) |
FI (1) | FI3067043T3 (zh) |
GT (1) | GT201000131A (zh) |
HK (3) | HK1149721A1 (zh) |
HR (3) | HRP20230178T3 (zh) |
HU (2) | HUE061321T2 (zh) |
IL (3) | IL262990B2 (zh) |
JO (1) | JOP20080499B1 (zh) |
MA (1) | MA31797B1 (zh) |
MX (1) | MX2010004930A (zh) |
MY (1) | MY153730A (zh) |
NZ (1) | NZ584686A (zh) |
PE (2) | PE20091390A1 (zh) |
PL (3) | PL2217205T3 (zh) |
PT (3) | PT2295035T (zh) |
RU (1) | RU2493844C3 (zh) |
SG (1) | SG185951A1 (zh) |
SI (3) | SI3067043T1 (zh) |
TN (1) | TN2010000200A1 (zh) |
TW (1) | TWI484982B (zh) |
WO (1) | WO2009061713A1 (zh) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG185951A1 (en) | 2007-11-06 | 2012-12-28 | Novartis Ag | Dual-acting pharmaceutical compositions based on superstructures of angiotensin receptor antagonist/blocker (arb) and neutral endopeptidase (nep) inhibitor |
KR20120041702A (ko) | 2009-05-28 | 2012-05-02 | 노파르티스 아게 | 네프릴리신 억제제로서의 치환된 아미노부티르산 유도체 |
AU2010251967B9 (en) | 2009-05-28 | 2014-04-03 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
BR112013004192A2 (pt) | 2010-08-24 | 2016-05-10 | Novartis Ag | tratamento de hipertensão e/ou prevenção ou tratamento de falha do coração em um mamífero que recebe terapia de anticoagulante |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
JP6482462B2 (ja) | 2012-08-24 | 2019-03-13 | ノバルティス アーゲー | 心房拡大又はリモデリングを特徴とする疾患を治療するためのnep阻害剤 |
KR20150119107A (ko) | 2013-02-14 | 2015-10-23 | 노파르티스 아게 | 개선된 생체내 효능을 갖는 nep 억제제로서의 치환된 비스페닐 부탄산 유도체 |
CU24330B1 (es) | 2013-02-14 | 2018-03-13 | Novartis Ag | Derivados del ácido 4-((1,1) bifenil-4-il)-3-(3-fosfonopropanamido) butanoico, activos como inhibidores de nep (endopeptidasa neutral) |
RS65037B1 (sr) | 2013-08-26 | 2024-02-29 | Novartis Ag | Lečenje kardiovaskularnih oboljenja |
EP3038653A1 (en) * | 2013-08-26 | 2016-07-06 | Novartis AG | New use |
CN106795099B (zh) * | 2014-04-10 | 2019-11-26 | 南京奥昭生物科技有限公司 | 用于治疗高血压和心血管疾病的前药和组合物 |
CN105461647B (zh) * | 2014-09-28 | 2018-06-29 | 四川海思科制药有限公司 | 缬沙坦沙库比曲三钠盐复合物的固态形式及其制备方法和用途 |
CN105873586B (zh) | 2014-12-08 | 2019-09-13 | 苏州晶云药物科技股份有限公司 | 一种包含缬沙坦和ahu377的三钠盐超分子复合物的晶型及其制备方法 |
CN104473938B (zh) * | 2014-12-30 | 2017-06-09 | 北京瑞都医药科技有限公司 | 一种治疗慢性心衰药物及其制备方法 |
CN104826115A (zh) * | 2015-04-19 | 2015-08-12 | 浙江巨泰药业有限公司 | 一种抗心衰药物组合物及其制备方法 |
FI3294283T3 (fi) | 2015-05-11 | 2023-05-24 | Novartis Ag | Sakubitriili-valsartaani-annostusohjelma sydämen vajaatoiminnan hoitamiseksi |
EP3302460A1 (en) | 2015-05-29 | 2018-04-11 | Novartis AG | Sacubitril and valsartan for treating metabolic disease |
CN106309388A (zh) * | 2015-06-30 | 2017-01-11 | 深圳信立泰药业股份有限公司 | 一种用于心衰治疗的药物组合物及其制备方法 |
WO2017006254A1 (en) | 2015-07-08 | 2017-01-12 | Novartis Ag | Drug combination comprising an angiotensin ii receptor antagonist, a neutral endopeptidase inhibitor and a mineralcorticoid receptor antagonist |
CN106176723A (zh) * | 2015-07-11 | 2016-12-07 | 凌莉 | 一种固体药物组合物及其制备方法 |
CN105997994A (zh) * | 2015-07-11 | 2016-10-12 | 凌莉 | 一种固体口服型制剂及其制备方法 |
CN106176724A (zh) * | 2015-07-11 | 2016-12-07 | 凌莉 | 一种稳定的固体药物组合物及其制备方法 |
CN106176725A (zh) * | 2015-07-11 | 2016-12-07 | 凌莉 | 一种提高稳定性的药物组合物及其制备方法和用途 |
CN105997993B (zh) * | 2015-07-11 | 2018-03-30 | 麦丽芳 | 一种用于心血管疾病治疗的固体口服型制剂及其制备方法 |
CN106074421A (zh) * | 2015-07-11 | 2016-11-09 | 凌莉 | 一种提高稳定性的药物组合物 |
WO2017012600A1 (en) | 2015-07-20 | 2017-01-26 | Zentiva, K.S. | A pharmaceutical composition containing valsartan and sacubitril and methods for preparation and stabilization thereof |
CN106397249A (zh) * | 2015-08-03 | 2017-02-15 | 深圳信立泰药业股份有限公司 | 一种高稳定性lcz696结晶粉末及其制备方法 |
WO2017037596A1 (en) * | 2015-08-28 | 2017-03-09 | Dr. Reddy's Laboratories Limited | Amorphous solid dispersion of lcz-696 |
JP6598985B2 (ja) | 2015-08-28 | 2019-10-30 | ノバルティス アーゲー | 新規の使用 |
CN106580908A (zh) * | 2015-10-16 | 2017-04-26 | 深圳信立泰药业股份有限公司 | 一种用于心血管疾病治疗的口服制剂及其制备方法 |
CN105669581B (zh) * | 2015-11-09 | 2017-03-22 | 成都苑东生物制药股份有限公司 | 一种血管紧张受体拮抗剂和中性内肽酶抑制剂复合物 |
WO2017085573A1 (en) * | 2015-11-20 | 2017-05-26 | Lupin Limited | Amorphous sacubitril-valsartan complex and process for preparation thereof |
CN105330609B (zh) * | 2015-12-07 | 2017-12-22 | 南京正大天晴制药有限公司 | 一种制备lcz696的方法 |
CN105929031B (zh) * | 2015-12-18 | 2018-08-21 | 重庆两江药物研发中心有限公司 | 一种血管紧张素受体拮抗剂和nep抑制剂的复合物中杂质的分离方法 |
CN105935358B (zh) * | 2015-12-18 | 2019-06-07 | 重庆两江药物研发中心有限公司 | 一种沙库比曲缬沙坦缓释剂及其制备方法 |
CN106905253B (zh) * | 2015-12-23 | 2020-01-03 | 正大天晴药业集团股份有限公司 | 一种超分子复合物的结晶 |
AU2017215530B2 (en) | 2016-02-03 | 2019-09-12 | Novartis Ag | Galenic formulations of organic compounds |
US10722471B2 (en) * | 2016-02-03 | 2020-07-28 | Novartis Ag | Galenic formulations of organic compounds |
CN105748420B (zh) * | 2016-03-04 | 2018-11-06 | 山东省药学科学院 | 一种治疗心力衰竭的lcz696缓释骨架片的制备方法 |
CN105902506A (zh) * | 2016-06-12 | 2016-08-31 | 佛山市腾瑞医药科技有限公司 | 一种沙卡布曲缬沙坦制剂及其应用 |
WO2018069937A1 (en) | 2016-10-13 | 2018-04-19 | Mylan Laboratories Limited | Solid dispersions of trisodium sacubitril valsartan and process for the preparation thereof |
EP3600255B1 (en) * | 2017-03-31 | 2021-07-07 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Stable hot-melt extrudate containing valsartan and sacubitril |
WO2018178295A1 (en) | 2017-03-31 | 2018-10-04 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Stable hot-melt extrudate containing valsartan and sacubitril |
WO2018211479A1 (en) | 2017-05-19 | 2018-11-22 | Lupin Limited | Stabilized compositions of angiotensin ii inhibitors and neutral endopeptidase inhibitors and process for preparation thereof |
WO2019008485A1 (en) * | 2017-07-06 | 2019-01-10 | Mankind Pharma Ltd | FIXED DOSE PHARMACEUTICAL COMPOSITION BASED ON VALSARTAN AND SACUBITRIL |
EP3658122B1 (en) | 2017-07-28 | 2021-04-07 | Synthon B.V. | Pharmaceutical composition comprising sacubitril and valsartan |
US20200276129A1 (en) | 2017-10-13 | 2020-09-03 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Tablet containing valsartan and sacubitril |
WO2019180735A1 (en) * | 2018-03-19 | 2019-09-26 | Natco Pharma Limited | Stable pharmaceutical compositions comprising sacubitril-valsartan complex |
WO2019246503A1 (en) | 2018-06-22 | 2019-12-26 | Ideaz, Llc | Diphenyl tablets and methods of preparing the same |
JP2021525791A (ja) | 2018-08-23 | 2021-09-27 | ノバルティス アーゲー | 新たな心不全治療用医薬の使用 |
WO2020039394A1 (en) | 2018-08-24 | 2020-02-27 | Novartis Ag | New drug combinations |
EP3766484B1 (en) | 2019-07-19 | 2021-08-25 | Zentiva, K.S. | Solid pharmaceutical dosage form comprising valsartan and sacubitril |
KR102545274B1 (ko) | 2020-02-26 | 2023-06-20 | 에리슨제약(주) | 사쿠비트릴 및 발사르탄을 포함하는 심부전 치료용 서방성 제제, 및 이를 포함하는 다중방출 복합제제와 이의 제조방법 |
KR20210120560A (ko) | 2020-03-27 | 2021-10-07 | 주식회사 유영제약 | 고함량의 주성분을 포함하는 정제 및 그 제조방법 |
KR20210138510A (ko) | 2020-05-12 | 2021-11-19 | 에리슨제약(주) | 사쿠비트릴, 발사르탄 및 네비보롤을 포함하는 심부전 및 허혈성 심질환의 예방 또는 치료용 약제학적 조성물 및 이를 포함하는 약제학적 복합제제 |
KR20220091767A (ko) | 2020-12-24 | 2022-07-01 | 주식회사 보령 | 사쿠비트릴 발사르탄 하이브리드 화합물 또는 그 약제학적으로 허용되는 염을 유효성분으로 포함하는 약제학적 조성물 |
KR102486815B1 (ko) | 2021-01-20 | 2023-01-10 | 주식회사 대웅제약 | Nep 저해제 및 arb를 포함하는 약학 조성물 및 이의 제조 방법 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US607355A (en) | 1898-07-12 | Carrier for bicycles | ||
US607893A (en) | 1898-07-26 | Automatic switch-operating machine | ||
US608220A (en) | 1898-08-02 | Mechanical movement | ||
US735093A (en) | 1903-01-31 | 1903-08-04 | Oscar Greenwald | Elevator-cable guard. |
GB9613470D0 (en) | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
KR100597922B1 (ko) * | 1997-11-17 | 2006-07-10 | 스미스클라인 비참 코포레이션 | 고용량 약물 로딩 속효성 및 변형 방출형 경구 투여용제형 및 그의 제조 방법 |
US6558699B2 (en) * | 1997-11-17 | 2003-05-06 | Smithkline Beecham Corporation | High drug load immediate and modified release oral dosage formulations and processes for their manufacture |
AU750122C (en) * | 1998-06-17 | 2003-02-27 | Bristol-Myers Squibb Company | Preventing cerebral infarction through administration of ADP-receptor antiplatelet and antihypertensive drugs in combination |
TR200805275T2 (tr) * | 1998-12-23 | 2008-09-22 | Novartis Ag | AT-1 veya AT-2 reseptörlerindeki artışın neden olduğu hastalıkların tedavisi için AT-1 reseptör antagonisti veya AT-2 reseptör modülatörünün kullanımı@ |
ES2309090T3 (es) | 2000-07-19 | 2008-12-16 | Novartis Ag | Sales de valsartan. |
DE60315795T2 (de) | 2002-01-17 | 2008-06-05 | Novartis Ag | Pharmazeutische zusammensetzung enthaltend valsartan und nep-inhibitoren |
US7468390B2 (en) * | 2002-01-17 | 2008-12-23 | Novartis Ag | Methods of treatment and pharmaceutical composition |
JP3751287B2 (ja) * | 2002-03-27 | 2006-03-01 | バイエル薬品株式会社 | 小型化されたニフェジピン有核錠剤 |
WO2003089417A1 (en) | 2002-04-15 | 2003-10-30 | Dr. Reddy's Laboratories Limited | Novel crystalline forms of (s)-n-(1-carboxy-2-methyl-prop-1-yl) -n-pentanoyl-n- [2’-(1h-tetrazol-5-yl-)- biphenyl-4-yl methyl] amine (valsartan) |
GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
CA2519490A1 (en) | 2003-03-17 | 2004-09-30 | Teva Pharmaceutical Industries Ltd | Polymorphis of valsartan |
EP1648515B1 (en) * | 2003-07-16 | 2012-11-21 | Boehringer Ingelheim International GmbH | Chlorthalidone combinations |
GB0402262D0 (en) * | 2004-02-02 | 2004-03-10 | Novartis Ag | Process for the manufacture of organic compounds |
GT200600371A (es) | 2005-08-17 | 2007-03-21 | Formas de dosis sólidas de valsartan y amlodipina y método para hacer las mismas | |
AU2006307470A1 (en) * | 2005-10-27 | 2007-05-03 | Lupin Limited | Pharmaceutical formulation of losartan |
WO2007052307A2 (en) | 2005-10-31 | 2007-05-10 | Lupin Limited | Stable solid oral dosage forms of valsartan |
EP1951111B1 (en) | 2005-11-07 | 2010-08-11 | Stryker Corporation | Patient handling device including local status indication, one-touch fowler angle adjustment, and power-on alarm configuration |
US20080261958A1 (en) | 2005-11-08 | 2008-10-23 | Randy Lee Webb | Combination of Organic Compounds |
AR057882A1 (es) * | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
EP1897537A1 (en) * | 2006-09-04 | 2008-03-12 | Novartis AG | Composition comprising an angiotensin II receptor antagonist |
SG185951A1 (en) | 2007-11-06 | 2012-12-28 | Novartis Ag | Dual-acting pharmaceutical compositions based on superstructures of angiotensin receptor antagonist/blocker (arb) and neutral endopeptidase (nep) inhibitor |
-
2008
- 2008-11-04 SG SG2012081394A patent/SG185951A1/en unknown
- 2008-11-04 JO JOP/2008/0499A patent/JOP20080499B1/ar active
- 2008-11-04 BR BRPI0823505-8A patent/BRPI0823505A2/pt not_active Application Discontinuation
- 2008-11-04 ES ES10173506.6T patent/ES2587336T3/es active Active
- 2008-11-04 SI SI200832204T patent/SI3067043T1/sl unknown
- 2008-11-04 CN CN200880114940A patent/CN101848700A/zh active Pending
- 2008-11-04 DK DK16157767.1T patent/DK3067043T3/da active
- 2008-11-04 CA CA2703598A patent/CA2703598C/en active Active
- 2008-11-04 EP EP22200982.1A patent/EP4186491A1/en active Pending
- 2008-11-04 AU AU2008324878A patent/AU2008324878B2/en active Active
- 2008-11-04 PE PE2008001886A patent/PE20091390A1/es not_active Application Discontinuation
- 2008-11-04 PE PE2013002393A patent/PE20141072A1/es active IP Right Grant
- 2008-11-04 IL IL262990A patent/IL262990B2/en unknown
- 2008-11-04 EP EP08848154.4A patent/EP2217205B1/en not_active Revoked
- 2008-11-04 RU RU2010123027A patent/RU2493844C3/ru active
- 2008-11-04 PT PT101735066T patent/PT2295035T/pt unknown
- 2008-11-04 KR KR1020157033633A patent/KR101700062B1/ko active IP Right Review Request
- 2008-11-04 CN CN2013101540642A patent/CN103251587A/zh active Pending
- 2008-11-04 EP EP16157767.1A patent/EP3067043B1/en active Active
- 2008-11-04 KR KR1020107009852A patent/KR101589317B1/ko active IP Right Review Request
- 2008-11-04 WO PCT/US2008/082324 patent/WO2009061713A1/en active Application Filing
- 2008-11-04 PT PT161577671T patent/PT3067043T/pt unknown
- 2008-11-04 DK DK08848154.4T patent/DK2217205T3/en active
- 2008-11-04 HU HUE16157767A patent/HUE061321T2/hu unknown
- 2008-11-04 HR HRP20230178TT patent/HRP20230178T3/hr unknown
- 2008-11-04 AR ARP080104826A patent/AR069184A1/es not_active Application Discontinuation
- 2008-11-04 HU HUE10173506A patent/HUE028866T2/en unknown
- 2008-11-04 SI SI200831654A patent/SI2295035T1/sl unknown
- 2008-11-04 ES ES16157767T patent/ES2939163T3/es active Active
- 2008-11-04 PL PL08848154T patent/PL2217205T3/pl unknown
- 2008-11-04 MY MYPI2010001722A patent/MY153730A/en unknown
- 2008-11-04 PL PL16157767.1T patent/PL3067043T3/pl unknown
- 2008-11-04 ES ES08848154.4T patent/ES2536514T3/es active Active
- 2008-11-04 NZ NZ584686A patent/NZ584686A/xx unknown
- 2008-11-04 EP EP10173506.6A patent/EP2295035B1/en not_active Revoked
- 2008-11-04 PT PT88481544T patent/PT2217205E/pt unknown
- 2008-11-04 JP JP2010533185A patent/JP5653218B2/ja active Active
- 2008-11-04 DK DK10173506.6T patent/DK2295035T3/en active
- 2008-11-04 US US12/741,251 patent/US20100267786A1/en not_active Abandoned
- 2008-11-04 PL PL10173506.6T patent/PL2295035T3/pl unknown
- 2008-11-04 MX MX2010004930A patent/MX2010004930A/es active IP Right Grant
- 2008-11-04 FI FIEP16157767.1T patent/FI3067043T3/fi active
- 2008-11-04 SI SI200831427T patent/SI2217205T1/sl unknown
- 2008-11-05 CL CL2008003298A patent/CL2008003298A1/es unknown
- 2008-11-05 TW TW097142724A patent/TWI484982B/zh active
-
2010
- 2010-04-19 IL IL205208A patent/IL205208A/en active IP Right Grant
- 2010-04-30 MA MA32803A patent/MA31797B1/fr unknown
- 2010-04-30 TN TN2010000200A patent/TN2010000200A1/fr unknown
- 2010-05-05 GT GT201000131A patent/GT201000131A/es unknown
- 2010-05-06 EC EC2010010160A patent/ECSP10010160A/es unknown
- 2010-10-19 HK HK11107642.4A patent/HK1149721A1/zh not_active IP Right Cessation
- 2010-10-19 HK HK10109891.9A patent/HK1143529A1/zh not_active IP Right Cessation
-
2014
- 2014-08-12 JP JP2014164022A patent/JP2015038069A/ja not_active Withdrawn
-
2015
- 2015-04-28 HR HRP20150459TT patent/HRP20150459T1/hr unknown
- 2015-05-14 CY CY20151100426T patent/CY1116280T1/el unknown
-
2016
- 2016-08-02 HR HRP20160988TT patent/HRP20160988T1/hr unknown
- 2016-08-08 CY CY20161100778T patent/CY1117883T1/el unknown
- 2016-10-31 HK HK16112495.7A patent/HK1224195A1/zh unknown
-
2017
- 2017-01-03 IL IL249922A patent/IL249922A0/en unknown
-
2020
- 2020-12-02 US US17/109,716 patent/US20210085631A1/en not_active Abandoned
-
2023
- 2023-05-09 US US18/314,745 patent/US20240115536A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL262990A (en) | Dual-activity pharmaceutical compositions based on angiotensin receptor antagonist/blocker (arb) and neutral endopeptidase (nep) inhibitor superstructures | |
HUS1600025I1 (hu) | Egy angiotenzin receptor antagonistát és egy NEP inhibitort tartalmazó gyógyászati kombinációk | |
ZA200901694B (en) | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use | |
PL2046887T3 (pl) | Kompozycje poliolefinowe ulegające sieciowaniu pod wpływem światła | |
IL192613A (en) | Cycloalkylamines and their pharmaceutical compositions | |
IL194734A0 (en) | Pharmaceutical compositions containing opioid antagonists | |
DK2059246T3 (da) | Terapeutiske sammensætninger omfattende en specifik endothelin-receptorantagonist og en PDE5-inhibitor | |
ZA200810178B (en) | Pharmaceutical compositions for sustained release of phenyephrine | |
HK1135110A1 (en) | Nk1 receptor antagonist composition nk1 | |
EP2155160A4 (en) | THIXOTROPIC PHARMACEUTICAL COMPOSITIONS | |
AP2009004881A0 (en) | Poly-TLR antagonist | |
ITMI20062230A1 (it) | Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende | |
ZA200704717B (en) | Pharmaceutical combinations of an angiotensin receptor antagonist and an NEP inhibitor | |
GB0619891D0 (en) | Pharmaceutical composition of risedronate | |
ZA200901001B (en) | Antiretroviral solid oral composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20201031 |