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HK1015686A1 - Use of phenol substituted diphosphonates as antineoplastic agents - Google Patents

Use of phenol substituted diphosphonates as antineoplastic agents

Info

Publication number
HK1015686A1
HK1015686A1 HK99100780A HK99100780A HK1015686A1 HK 1015686 A1 HK1015686 A1 HK 1015686A1 HK 99100780 A HK99100780 A HK 99100780A HK 99100780 A HK99100780 A HK 99100780A HK 1015686 A1 HK1015686 A1 HK 1015686A1
Authority
HK
Hong Kong
Prior art keywords
pct
antineoplastic agents
phenol substituted
sec
diphosphonates
Prior art date
Application number
HK99100780A
Other languages
English (en)
Inventor
Eric Niesor
Craig Leigh Bentzen
Lan Mong Nguyen
Jean-Luc Thuillard
Hieu Trung Phan
Jean Flach
Original Assignee
Symphar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphar Sa filed Critical Symphar Sa
Publication of HK1015686A1 publication Critical patent/HK1015686A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK99100780A 1995-07-28 1999-02-26 Use of phenol substituted diphosphonates as antineoplastic agents HK1015686A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH02213/95A CH690163A5 (fr) 1995-07-28 1995-07-28 Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
PCT/EP1996/003301 WO1997004785A1 (en) 1995-07-28 1996-07-26 Use of phenol substituted diphosphonates as antineoplastic agents

Publications (1)

Publication Number Publication Date
HK1015686A1 true HK1015686A1 (en) 1999-10-22

Family

ID=4228513

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99100780A HK1015686A1 (en) 1995-07-28 1999-02-26 Use of phenol substituted diphosphonates as antineoplastic agents

Country Status (15)

Country Link
US (1) US6127350A (xx)
EP (1) EP0845991B1 (xx)
JP (1) JPH11511127A (xx)
CN (1) CN1091601C (xx)
AT (1) ATE212847T1 (xx)
AU (1) AU723094B2 (xx)
CA (1) CA2228212A1 (xx)
CH (1) CH690163A5 (xx)
DE (1) DE69619117T2 (xx)
DK (1) DK0845991T3 (xx)
ES (1) ES2172675T3 (xx)
HK (1) HK1015686A1 (xx)
PT (1) PT845991E (xx)
WO (1) WO1997004785A1 (xx)
ZA (1) ZA966364B (xx)

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JP5501227B2 (ja) 2007-06-27 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体
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ES2855142T3 (es) * 2012-03-23 2021-09-23 Array Biopharma Inc Compuestos para la utilización en el tratamiento de las metástasis cerebrales en un paciente con cáncer de mama ErbB2+
EP2844261B1 (en) 2012-05-02 2018-10-17 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH675422A5 (xx) * 1988-03-31 1990-09-28 Symphar Sa
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物

Also Published As

Publication number Publication date
CN1192148A (zh) 1998-09-02
PT845991E (pt) 2002-07-31
CA2228212A1 (en) 1997-02-13
CN1091601C (zh) 2002-10-02
EP0845991A2 (en) 1998-06-10
US6127350A (en) 2000-10-03
DE69619117D1 (de) 2002-03-21
DK0845991T3 (da) 2002-05-27
WO1997004785A1 (en) 1997-02-13
DE69619117T2 (de) 2002-09-19
ATE212847T1 (de) 2002-02-15
AU723094B2 (en) 2000-08-17
JPH11511127A (ja) 1999-09-28
AU6787496A (en) 1997-02-26
CH690163A5 (fr) 2000-05-31
ZA966364B (en) 1997-02-11
EP0845991B1 (en) 2002-02-06
ES2172675T3 (es) 2002-10-01

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20060726