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HK1006309A1 - A process for the optical resolution of droproizine - Google Patents

A process for the optical resolution of droproizine

Info

Publication number
HK1006309A1
HK1006309A1 HK98105521A HK98105521A HK1006309A1 HK 1006309 A1 HK1006309 A1 HK 1006309A1 HK 98105521 A HK98105521 A HK 98105521A HK 98105521 A HK98105521 A HK 98105521A HK 1006309 A1 HK1006309 A1 HK 1006309A1
Authority
HK
Hong Kong
Prior art keywords
optical resolution
droproizine
carried out
aqueous medium
tartaric acid
Prior art date
Application number
HK98105521A
Other languages
English (en)
Inventor
Roberto Giani
Original Assignee
Dompe Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Farmaceutici Spa filed Critical Dompe Farmaceutici Spa
Publication of HK1006309A1 publication Critical patent/HK1006309A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Semiconductor Lasers (AREA)
  • Prostheses (AREA)
  • Indole Compounds (AREA)
  • Glass Compositions (AREA)
HK98105521A 1989-07-20 1998-06-17 A process for the optical resolution of droproizine HK1006309A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8921244A IT1231158B (it) 1989-07-20 1989-07-20 Procedimento per la risoluzione ottica della dropropizina.

Publications (1)

Publication Number Publication Date
HK1006309A1 true HK1006309A1 (en) 1999-02-19

Family

ID=11178946

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98105521A HK1006309A1 (en) 1989-07-20 1998-06-17 A process for the optical resolution of droproizine

Country Status (12)

Country Link
US (1) US5087698A (xx)
EP (1) EP0409044B1 (xx)
JP (1) JP2977237B2 (xx)
KR (1) KR0146047B1 (xx)
AT (1) ATE116975T1 (xx)
CA (1) CA2007385C (xx)
DE (2) DE69015907T2 (xx)
ES (1) ES2019010A6 (xx)
GR (2) GR910300062T1 (xx)
HK (1) HK1006309A1 (xx)
IT (1) IT1231158B (xx)
PT (1) PT92767B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254452B (it) * 1992-02-14 1995-09-25 Dompe Farmaceutici Spa N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IT1254993B (it) * 1992-06-24 1995-10-11 Procedimento per la preparazione degli enantiomeri della dropropizina
IN187238B (xx) * 1995-06-30 2002-03-09 Astra Ab
DE19821039A1 (de) * 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE601394A (xx) *
NL275711A (xx) * 1962-03-15
US4255426A (en) * 1979-07-09 1981-03-10 Pfizer Inc. 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines
US4312877A (en) * 1979-07-09 1982-01-26 Pfizer Inc. 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted piperidines, pharmaceutical compositions, thereof and use thereof
IT1210639B (it) * 1981-02-25 1989-09-14 Menarini Sas Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione
IT1203721B (it) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
NL8801622A (nl) * 1988-06-25 1990-01-16 Stamicarbon Bereiding van enantiomeren van dropropizine.
IT1217950B (it) * 1988-06-28 1990-03-30 Dott Formenti Ind Chimica E Fa Sali di (r,s) 3 (4 fenil 1 piperazinil) 1,2 propandtolo
IT1226570B (it) * 1988-08-01 1991-01-24 Bidachem Spa Procedimento di preparazione della levo- e destro-dropropizina

Also Published As

Publication number Publication date
EP0409044A2 (en) 1991-01-23
DE69015907T2 (de) 1995-05-24
DE409044T1 (de) 1991-07-25
CA2007385A1 (en) 1991-01-20
JPH0381270A (ja) 1991-04-05
PT92767A (pt) 1991-03-20
KR0146047B1 (ko) 1998-08-17
DE69015907D1 (de) 1995-02-23
IT8921244A0 (it) 1989-07-20
ES2019010A6 (es) 1991-05-16
KR910002745A (ko) 1991-02-26
GR910300062T1 (en) 1991-11-15
EP0409044B1 (en) 1995-01-11
PT92767B (pt) 1995-11-30
CA2007385C (en) 1997-12-30
JP2977237B2 (ja) 1999-11-15
US5087698A (en) 1992-02-11
GR3014936T3 (en) 1995-05-31
IT1231158B (it) 1991-11-19
EP0409044A3 (en) 1991-05-29
ATE116975T1 (de) 1995-01-15

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Effective date: 20100709