HK1098128A1 - New crystalline form v of agomelatine, a process for its preparation and pharmaceutical compositions containing it - Google Patents

New crystalline form v of agomelatine, a process for its preparation and pharmaceutical compositions containing it

Info

Publication number: HK1098128A1
Authority: HK; Hong Kong
Prior art keywords: agomelatine; preparation; pharmaceutical compositions; crystalline form; compositions containing
Prior art date: 2005-08-03

Application number

HK07104583.8A

Other languages

English (en)

Inventor

Gerard Coquerel

Julie Linol

Jean-Claude Souvie

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-03

Filing date

2007-04-30

Publication date

2007-07-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36581629&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1098128(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-04-30 Application filed by Servier Lab filed Critical Servier Lab

2007-07-13 Publication of HK1098128A1 publication Critical patent/HK1098128A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Gynecology & Obstetrics (AREA)
Obesity (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Cardiology (AREA)
Pregnancy & Childbirth (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Medicinal Preparation (AREA)

HK07104583.8A 2005-08-03 2007-04-30 New crystalline form v of agomelatine, a process for its preparation and pharmaceutical compositions containing it HK1098128A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0508278A FR2889523B1 (fr)	2005-08-03	2005-08-03	Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Publications (1)

Publication Number	Publication Date
HK1098128A1 true HK1098128A1 (en)	2007-07-13

Family

ID=36581629

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK07104583.8A HK1098128A1 (en)	2005-08-03	2007-04-30	New crystalline form v of agomelatine, a process for its preparation and pharmaceutical compositions containing it

Country Status (38)

Country	Link
EP (2)	EP2277857A3 (xx)
JP (1)	JP4575337B2 (xx)
CN (1)	CN100448843C (xx)
AP (1)	AP2486A (xx)
AR (1)	AR057715A1 (xx)
AU (1)	AU2006203342B2 (xx)
BR (1)	BRPI0603059A (xx)
CA (1)	CA2555115C (xx)
CR (1)	CR8529A (xx)
CU (1)	CU20060153A7 (xx)
CY (1)	CY1113011T1 (xx)
DK (1)	DK1752443T3 (xx)
EA (1)	EA011030B1 (xx)
EC (1)	ECSP066715A (xx)
ES (1)	ES2391406T3 (xx)
FR (1)	FR2889523B1 (xx)
GT (1)	GT200600346A (xx)
HK (1)	HK1098128A1 (xx)
HR (1)	HRP20120779T1 (xx)
IL (1)	IL177173A (xx)
JO (1)	JO2793B1 (xx)
MA (1)	MA28451B1 (xx)
ME (1)	ME02026B (xx)
MX (1)	MXPA06008789A (xx)
MY (1)	MY139902A (xx)
NO (1)	NO336967B1 (xx)
NZ (1)	NZ548864A (xx)
PE (1)	PE20070365A1 (xx)
PL (1)	PL1752443T3 (xx)
PT (1)	PT1752443E (xx)
RS (1)	RS52423B (xx)
SA (1)	SA06270255B1 (xx)
SG (1)	SG130110A1 (xx)
SI (1)	SI1752443T1 (xx)
TW (1)	TWI359128B (xx)
UA (1)	UA83720C2 (xx)
WO (1)	WO2007015004A2 (xx)
ZA (1)	ZA200606453B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2934856B1 (fr) *	2008-08-05	2010-08-13	Servier Lab	Nouveau procede d'obtention de la forme cristalline v de l'agomelatine
CN101481321B (zh) *	2009-02-27	2012-04-18	上海医药工业研究院	阿戈美拉汀卤化氢复合物及其制备方法
CN101585779B (zh)	2009-03-10	2014-04-02	上海医药工业研究院	阿戈美拉汀的晶型vi及其制备方法和应用
WO2011006387A1 (zh) *	2009-07-11	2011-01-20	浙江华海药业股份有限公司	阿戈美拉汀的制备方法、阿戈美拉汀晶形及其制备方法
CN102001959B (zh) *	2009-09-01	2014-07-02	北京本草天源药物研究院	一种药物晶体及其制备方法和用途
CN102050755B (zh) *	2009-10-29	2014-11-05	重庆医药工业研究院有限责任公司	阿戈美拉汀的晶型及其制备方法
CN101781226B (zh)	2009-12-23	2012-03-28	天津泰普药品科技发展有限公司	阿戈美拉汀及其药物组合物
EP2580183B1 (en)	2010-06-10	2014-07-23	Gador S.A.	New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide
CN102000583B (zh) *	2010-11-18	2012-08-15	烟台万华聚氨酯股份有限公司	一种氯化氢氧化制氯气的催化剂及其制备方法
CN102690209A (zh) *	2011-03-23	2012-09-26	上海医药工业研究院	阿戈美拉汀的混晶(形式-ⅷ)、其制备方法、应用和包含其的药物组合物
CN102690210A (zh) *	2011-03-23	2012-09-26	上海医药工业研究院	阿戈美拉汀的新晶型ⅶ、其制备方法、应用和包含其的药物组合物
CN106316910A (zh) *	2011-06-02	2017-01-11	奇诺因私人有限公司	用于制备前列腺素酰胺的新的方法
FR2978916B1 (fr)	2011-08-10	2013-07-26	Servier Lab	Composition pharmaceutique solide pour administration buccale d'agomelatine
ES2634243T3 (es)	2011-11-30	2017-09-27	Ratiopharm Gmbh	Complejo de agomelatina-urea y formas cristalinas del mismo
CZ2012108A3 (en)	2012-02-15	2013-02-27	Zentiva Ks	A method for the manufacture of a polymorphously stable pharmaceutical composition containing agomelatine
CN103360275B (zh) *	2012-03-30	2015-04-22	上海创诺制药有限公司	一种制备阿戈美拉汀ⅰ型晶体的方法
WO2014096373A1 (en)	2012-12-21	2014-06-26	Laboratorios Lesvi, S. L.	Process for prepararing n-(2-(7-methoxy-1-naphthalenyl)ethyl) acetamide and solid forms thereof
FR3001894A1 (fr)	2013-02-08	2014-08-15	Servier Lab	Composition pharmaceutique solide pour administration buccale d'agomelatine
EP2810647A1 (en)	2013-06-06	2014-12-10	Zentiva, a.s.	Pharmaceutical formulations comprising agomelatine in the form of agomelatine co-crystal with an organic acid
PL2810656T3 (pl)	2013-06-06	2018-01-31	Zentiva Ks	Preparaty agomelatyny zawierające agomelatynę w postaci kokryształów
CZ2013621A3 (cs)	2013-08-13	2015-02-25	Zentiva, K.S.	Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci
WO2015124496A1 (en)	2014-02-19	2015-08-27	Synthon B.V.	Pharmaceutical composition comprising amorphous agomelatine
FR3033131B1 (fr)	2015-02-26	2017-11-17	Servitronique	Glissiere pour ses systemes de reglage coulissants et procede d'assemblage
PL3075724T3 (pl)	2015-03-31	2023-12-27	F.I.S.- Fabbrica Italiana Sintetici S.P.A.	Stała postać agomelatyny
EP3466923A1 (en)	2017-10-09	2019-04-10	KRKA, d.d., Novo mesto	Process for the preparation of agomelatine in crystalline form
EP3466413A1 (en)	2017-10-09	2019-04-10	KRKA, d.d., Novo mesto	Pharmaceutical composition containing agomelatine and process for the preparation thereof
CN113952323A (zh) *	2021-12-10	2022-01-21	李甜	阿戈美拉汀在抑制Ube2c蛋白表达中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2658818B1 (fr) *	1990-02-27	1993-12-31	Adir Cie	Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866336B1 (fr) *	2004-02-13	2006-03-24	Servier Lab	Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine
FR2866335B1 (fr) *	2004-02-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'agomelatine

2005
- 2005-08-03 FR FR0508278A patent/FR2889523B1/fr not_active Expired - Fee Related
2006
- 2006-07-19 PE PE2006000868A patent/PE20070365A1/es not_active Application Discontinuation
- 2006-07-20 EC EC2006006715A patent/ECSP066715A/es unknown
- 2006-07-24 MA MA29212A patent/MA28451B1/fr unknown
- 2006-07-24 AP AP2006003695A patent/AP2486A/xx active
- 2006-07-24 CR CR8529A patent/CR8529A/es unknown
- 2006-07-24 JO JO2006247A patent/JO2793B1/en active
- 2006-07-31 GT GT200600346A patent/GT200600346A/es unknown
- 2006-07-31 IL IL177173A patent/IL177173A/en active IP Right Grant
- 2006-08-01 SA SA06270255A patent/SA06270255B1/ar unknown
- 2006-08-01 NZ NZ548864A patent/NZ548864A/en not_active IP Right Cessation
- 2006-08-01 SG SG200605171-8A patent/SG130110A1/en unknown
- 2006-08-02 WO PCT/FR2006/001869 patent/WO2007015004A2/fr active Application Filing
- 2006-08-02 ME MEP-2012-327A patent/ME02026B/me unknown
- 2006-08-02 DK DK06291251.4T patent/DK1752443T3/da active
- 2006-08-02 PT PT06291251T patent/PT1752443E/pt unknown
- 2006-08-02 SI SI200631396T patent/SI1752443T1/sl unknown
- 2006-08-02 TW TW095128302A patent/TWI359128B/zh not_active IP Right Cessation
- 2006-08-02 UA UAA200608689A patent/UA83720C2/ru unknown
- 2006-08-02 RS RS20120327A patent/RS52423B/en unknown
- 2006-08-02 NO NO20063517A patent/NO336967B1/no unknown
- 2006-08-02 CU CU20060153A patent/CU20060153A7/es unknown
- 2006-08-02 EP EP10011469A patent/EP2277857A3/fr not_active Withdrawn
- 2006-08-02 MY MYPI20063736A patent/MY139902A/en unknown
- 2006-08-02 PL PL06291251T patent/PL1752443T3/pl unknown
- 2006-08-02 AR ARP060103366A patent/AR057715A1/es not_active Application Discontinuation
- 2006-08-02 ES ES06291251T patent/ES2391406T3/es active Active
- 2006-08-02 EA EA200601273A patent/EA011030B1/ru unknown
- 2006-08-02 EP EP06291251A patent/EP1752443B1/fr active Active
- 2006-08-02 BR BRPI0603059-9A patent/BRPI0603059A/pt not_active Application Discontinuation
- 2006-08-03 JP JP2006211622A patent/JP4575337B2/ja not_active Expired - Fee Related
- 2006-08-03 MX MXPA06008789A patent/MXPA06008789A/es active IP Right Grant
- 2006-08-03 CA CA2555115A patent/CA2555115C/fr active Active
- 2006-08-03 AU AU2006203342A patent/AU2006203342B2/en not_active Ceased
- 2006-08-03 ZA ZA200606453A patent/ZA200606453B/en unknown
- 2006-08-03 CN CNB2006101083952A patent/CN100448843C/zh not_active Expired - Fee Related
2007
- 2007-04-30 HK HK07104583.8A patent/HK1098128A1/xx not_active IP Right Cessation
2012
- 2012-07-18 CY CY20121100635T patent/CY1113011T1/el unknown
- 2012-10-01 HR HRP20120779TT patent/HRP20120779T1/hr unknown

Also Published As

Publication number	Publication date
AP2486A (en)	2012-10-03
MY139902A (en)	2009-11-30
IL177173A0 (en)	2006-12-10
RS52423B (en)	2013-02-28
FR2889523B1 (fr)	2007-12-28
SA06270255B1 (ar)	2010-06-13
JP2007056017A (ja)	2007-03-08
CN1907958A (zh)	2007-02-07
EP2277857A3 (fr)	2011-06-01
HRP20120779T1 (hr)	2012-10-31
AP2006003695A0 (en)	2006-08-31
CR8529A (es)	2006-12-07
TW200736199A (en)	2007-10-01
AU2006203342A1 (en)	2007-02-22
WO2007015004A2 (fr)	2007-02-08
CN100448843C (zh)	2009-01-07
PL1752443T3 (pl)	2012-11-30
GT200600346A (es)	2007-02-28
EP1752443A1 (fr)	2007-02-14
AU2006203342B2 (en)	2012-07-19
ES2391406T3 (es)	2012-11-26
DK1752443T3 (da)	2012-10-22
PE20070365A1 (es)	2007-06-02
PT1752443E (pt)	2012-07-25
SI1752443T1 (sl)	2012-10-30
EP1752443B1 (fr)	2012-07-11
SG130110A1 (en)	2007-03-20
UA83720C2 (ru)	2008-08-11
CU20060153A7 (es)	2012-04-15
JO2793B1 (en)	2014-03-15
EA200601273A1 (ru)	2007-02-27
CY1113011T1 (el)	2016-04-13
MA28451B1 (fr)	2007-03-01
CA2555115C (fr)	2013-12-10
MXPA06008789A (es)	2007-02-02
JP4575337B2 (ja)	2010-11-04
FR2889523A1 (fr)	2007-02-09
EP2277857A2 (fr)	2011-01-26
EA011030B1 (ru)	2008-12-30
IL177173A (en)	2011-10-31
NO20063517L (no)	2007-02-05
AR057715A1 (es)	2007-12-12
ECSP066715A (xx)	2007-03-29
CA2555115A1 (fr)	2007-02-03
WO2007015004A3 (fr)	2007-03-22
NZ548864A (en)	2008-03-28
ME02026B (me)	2012-11-06
ZA200606453B (en)	2007-12-27
NO336967B1 (no)	2015-12-07
TWI359128B (en)	2012-03-01
BRPI0603059A (pt)	2007-08-14

Publication	Publication Date	Title
SG130110A1 (en)	2007-03-20	New crystalline form v of agomelatine, a process for its preparation and pharmaceutical compositions containing it
HK1098129A1 (en)	2007-07-13	New crystalline form iv of agomelatine, a process for its preparation and pharmaceutical compositions containing it
HK1098130A1 (en)	2007-07-13	New crystalline form iii of agomelatine, a process for its preparation and pharmaceutical compositions containing it
IL194931A0 (en)	2009-11-18	New crystalline form vi of agomelatine, a process for its preparation and pharmaceutical compositions containing it
HK1096659A1 (en)	2007-06-08	Crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it
IL178544A (en)	2017-04-30	Crystalline form - δ of ivabradine hydrochloride, process for preparation and pharmaceutical preparations containing it
TWI315306B (en)	2009-10-01	Bd-crystalline form of ivabradine hydrochloride, a process for its preparation and pharmaceutical compositions containing it
SG131857A1 (en)	2007-05-28	δD-CRYSTALLINE FORM OF IV ABRADINE HYDROCHLORIDE, A PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
HK1107081A1 (en)	2008-03-28	New process for the synthesis and new crystalline form of agomelatine and pharmaceutical compositions containing it
ME02750B (me)	2010-05-07	Kristalni oblik gama - d iv abradin hlorhidrata, postupak njegove izrade i farmaceutske smeše koje ga sadrže
HK1096387A1 (en)	2007-06-01	ß-CRYSTALLINE FORM OF IVABRADINE HYDROCHLORIDE, A PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
IL187359A (en)	2013-04-30	Tigzycline crystalline form i, a preparation containing it, a process for its preparation and use for the preparation of a pharmacological preparation for parenteral use

Legal Events

Date	Code	Title	Description
2022-03-04	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20210808