ME02026B - Novi kristalni v oblik agomelatina, postupak za njegovu proizvodnju i farmaceutske smiješe koje ga sadrže - Google Patents

Novi kristalni v oblik agomelatina, postupak za njegovu proizvodnju i farmaceutske smiješe koje ga sadrže

Info

Publication number: ME02026B
Authority: ME; Montenegro
Prior art keywords: agometaline; preparation; pharmaceutical compositions; crystalline form; compositions containing
Prior art date: 2005-08-03

Application number

MEP-2012-327A

Other languages

German (de)

English (en)

French (fr)

Inventor

Jean-Claude Souvie

Gérard Coquerel

Julie Linol

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-03

Filing date

2006-08-02

Publication date

2012-11-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36581629&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02026(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-08-02 Application filed by Servier Lab filed Critical Servier Lab

2012-11-06 Publication of ME02026B publication Critical patent/ME02026B/me

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Gynecology & Obstetrics (AREA)
Obesity (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Cardiology (AREA)
Pregnancy & Childbirth (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Medicinal Preparation (AREA)

MEP-2012-327A 2005-08-03 2006-08-02 Novi kristalni v oblik agomelatina, postupak za njegovu proizvodnju i farmaceutske smiješe koje ga sadrže ME02026B (me)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0508278A FR2889523B1 (fr)	2005-08-03	2005-08-03	Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
EP06291251A EP1752443B1 (fr)	2005-08-03	2006-08-02	Nouvelle forme cristalline V de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Publications (1)

Publication Number	Publication Date
ME02026B true ME02026B (me)	2012-11-06

Family

ID=36581629

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-2012-327A ME02026B (me)	2005-08-03	2006-08-02	Novi kristalni v oblik agomelatina, postupak za njegovu proizvodnju i farmaceutske smiješe koje ga sadrže

Country Status (38)

Country	Link
EP (2)	EP2277857A3 (me)
JP (1)	JP4575337B2 (me)
CN (1)	CN100448843C (me)
AP (1)	AP2486A (me)
AR (1)	AR057715A1 (me)
AU (1)	AU2006203342B2 (me)
BR (1)	BRPI0603059A (me)
CA (1)	CA2555115C (me)
CR (1)	CR8529A (me)
CU (1)	CU20060153A7 (me)
CY (1)	CY1113011T1 (me)
DK (1)	DK1752443T3 (me)
EA (1)	EA011030B1 (me)
EC (1)	ECSP066715A (me)
ES (1)	ES2391406T3 (me)
FR (1)	FR2889523B1 (me)
GT (1)	GT200600346A (me)
HK (1)	HK1098128A1 (me)
HR (1)	HRP20120779T1 (me)
IL (1)	IL177173A (me)
JO (1)	JO2793B1 (me)
MA (1)	MA28451B1 (me)
ME (1)	ME02026B (me)
MX (1)	MXPA06008789A (me)
MY (1)	MY139902A (me)
NO (1)	NO336967B1 (me)
NZ (1)	NZ548864A (me)
PE (1)	PE20070365A1 (me)
PL (1)	PL1752443T3 (me)
PT (1)	PT1752443E (me)
RS (1)	RS52423B (me)
SA (1)	SA06270255B1 (me)
SG (1)	SG130110A1 (me)
SI (1)	SI1752443T1 (me)
TW (1)	TWI359128B (me)
UA (1)	UA83720C2 (me)
WO (1)	WO2007015004A2 (me)
ZA (1)	ZA200606453B (me)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2934856B1 (fr) *	2008-08-05	2010-08-13	Servier Lab	Nouveau procede d'obtention de la forme cristalline v de l'agomelatine
CN101481321B (zh) *	2009-02-27	2012-04-18	上海医药工业研究院	阿戈美拉汀卤化氢复合物及其制备方法
CN101585779B (zh)	2009-03-10	2014-04-02	上海医药工业研究院	阿戈美拉汀的晶型vi及其制备方法和应用
WO2011006387A1 (zh) *	2009-07-11	2011-01-20	浙江华海药业股份有限公司	阿戈美拉汀的制备方法、阿戈美拉汀晶形及其制备方法
CN102001959B (zh) *	2009-09-01	2014-07-02	北京本草天源药物研究院	一种药物晶体及其制备方法和用途
CN102050755B (zh) *	2009-10-29	2014-11-05	重庆医药工业研究院有限责任公司	阿戈美拉汀的晶型及其制备方法
CN101781226B (zh)	2009-12-23	2012-03-28	天津泰普药品科技发展有限公司	阿戈美拉汀及其药物组合物
EP2580183B1 (en)	2010-06-10	2014-07-23	Gador S.A.	New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide
CN102000583B (zh) *	2010-11-18	2012-08-15	烟台万华聚氨酯股份有限公司	一种氯化氢氧化制氯气的催化剂及其制备方法
CN102690209A (zh) *	2011-03-23	2012-09-26	上海医药工业研究院	阿戈美拉汀的混晶(形式-ⅷ)、其制备方法、应用和包含其的药物组合物
CN102690210A (zh) *	2011-03-23	2012-09-26	上海医药工业研究院	阿戈美拉汀的新晶型ⅶ、其制备方法、应用和包含其的药物组合物
CN106316910A (zh) *	2011-06-02	2017-01-11	奇诺因私人有限公司	用于制备前列腺素酰胺的新的方法
FR2978916B1 (fr)	2011-08-10	2013-07-26	Servier Lab	Composition pharmaceutique solide pour administration buccale d'agomelatine
ES2634243T3 (es)	2011-11-30	2017-09-27	Ratiopharm Gmbh	Complejo de agomelatina-urea y formas cristalinas del mismo
CZ2012108A3 (en)	2012-02-15	2013-02-27	Zentiva Ks	A method for the manufacture of a polymorphously stable pharmaceutical composition containing agomelatine
CN103360275B (zh) *	2012-03-30	2015-04-22	上海创诺制药有限公司	一种制备阿戈美拉汀ⅰ型晶体的方法
WO2014096373A1 (en)	2012-12-21	2014-06-26	Laboratorios Lesvi, S. L.	Process for prepararing n-(2-(7-methoxy-1-naphthalenyl)ethyl) acetamide and solid forms thereof
FR3001894A1 (fr)	2013-02-08	2014-08-15	Servier Lab	Composition pharmaceutique solide pour administration buccale d'agomelatine
EP2810647A1 (en)	2013-06-06	2014-12-10	Zentiva, a.s.	Pharmaceutical formulations comprising agomelatine in the form of agomelatine co-crystal with an organic acid
PL2810656T3 (pl)	2013-06-06	2018-01-31	Zentiva Ks	Preparaty agomelatyny zawierające agomelatynę w postaci kokryształów
CZ2013621A3 (cs)	2013-08-13	2015-02-25	Zentiva, K.S.	Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci
WO2015124496A1 (en)	2014-02-19	2015-08-27	Synthon B.V.	Pharmaceutical composition comprising amorphous agomelatine
FR3033131B1 (fr)	2015-02-26	2017-11-17	Servitronique	Glissiere pour ses systemes de reglage coulissants et procede d'assemblage
PL3075724T3 (pl)	2015-03-31	2023-12-27	F.I.S.- Fabbrica Italiana Sintetici S.P.A.	Stała postać agomelatyny
EP3466923A1 (en)	2017-10-09	2019-04-10	KRKA, d.d., Novo mesto	Process for the preparation of agomelatine in crystalline form
EP3466413A1 (en)	2017-10-09	2019-04-10	KRKA, d.d., Novo mesto	Pharmaceutical composition containing agomelatine and process for the preparation thereof
CN113952323A (zh) *	2021-12-10	2022-01-21	李甜	阿戈美拉汀在抑制Ube2c蛋白表达中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2658818B1 (fr) *	1990-02-27	1993-12-31	Adir Cie	Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866336B1 (fr) *	2004-02-13	2006-03-24	Servier Lab	Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine
FR2866335B1 (fr) *	2004-02-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'agomelatine

2005
- 2005-08-03 FR FR0508278A patent/FR2889523B1/fr not_active Expired - Fee Related
2006
- 2006-07-19 PE PE2006000868A patent/PE20070365A1/es not_active Application Discontinuation
- 2006-07-20 EC EC2006006715A patent/ECSP066715A/es unknown
- 2006-07-24 MA MA29212A patent/MA28451B1/fr unknown
- 2006-07-24 AP AP2006003695A patent/AP2486A/xx active
- 2006-07-24 CR CR8529A patent/CR8529A/es unknown
- 2006-07-24 JO JO2006247A patent/JO2793B1/en active
- 2006-07-31 GT GT200600346A patent/GT200600346A/es unknown
- 2006-07-31 IL IL177173A patent/IL177173A/en active IP Right Grant
- 2006-08-01 SA SA06270255A patent/SA06270255B1/ar unknown
- 2006-08-01 NZ NZ548864A patent/NZ548864A/en not_active IP Right Cessation
- 2006-08-01 SG SG200605171-8A patent/SG130110A1/en unknown
- 2006-08-02 WO PCT/FR2006/001869 patent/WO2007015004A2/fr active Application Filing
- 2006-08-02 ME MEP-2012-327A patent/ME02026B/me unknown
- 2006-08-02 DK DK06291251.4T patent/DK1752443T3/da active
- 2006-08-02 PT PT06291251T patent/PT1752443E/pt unknown
- 2006-08-02 SI SI200631396T patent/SI1752443T1/sl unknown
- 2006-08-02 TW TW095128302A patent/TWI359128B/zh not_active IP Right Cessation
- 2006-08-02 UA UAA200608689A patent/UA83720C2/ru unknown
- 2006-08-02 RS RS20120327A patent/RS52423B/en unknown
- 2006-08-02 NO NO20063517A patent/NO336967B1/no unknown
- 2006-08-02 CU CU20060153A patent/CU20060153A7/es unknown
- 2006-08-02 EP EP10011469A patent/EP2277857A3/fr not_active Withdrawn
- 2006-08-02 MY MYPI20063736A patent/MY139902A/en unknown
- 2006-08-02 PL PL06291251T patent/PL1752443T3/pl unknown
- 2006-08-02 AR ARP060103366A patent/AR057715A1/es not_active Application Discontinuation
- 2006-08-02 ES ES06291251T patent/ES2391406T3/es active Active
- 2006-08-02 EA EA200601273A patent/EA011030B1/ru unknown
- 2006-08-02 EP EP06291251A patent/EP1752443B1/fr active Active
- 2006-08-02 BR BRPI0603059-9A patent/BRPI0603059A/pt not_active Application Discontinuation
- 2006-08-03 JP JP2006211622A patent/JP4575337B2/ja not_active Expired - Fee Related
- 2006-08-03 MX MXPA06008789A patent/MXPA06008789A/es active IP Right Grant
- 2006-08-03 CA CA2555115A patent/CA2555115C/fr active Active
- 2006-08-03 AU AU2006203342A patent/AU2006203342B2/en not_active Ceased
- 2006-08-03 ZA ZA200606453A patent/ZA200606453B/en unknown
- 2006-08-03 CN CNB2006101083952A patent/CN100448843C/zh not_active Expired - Fee Related
2007
- 2007-04-30 HK HK07104583.8A patent/HK1098128A1/xx not_active IP Right Cessation
2012
- 2012-07-18 CY CY20121100635T patent/CY1113011T1/el unknown
- 2012-10-01 HR HRP20120779TT patent/HRP20120779T1/hr unknown

Also Published As

Publication number	Publication date
AP2486A (en)	2012-10-03
MY139902A (en)	2009-11-30
IL177173A0 (en)	2006-12-10
RS52423B (en)	2013-02-28
FR2889523B1 (fr)	2007-12-28
SA06270255B1 (ar)	2010-06-13
JP2007056017A (ja)	2007-03-08
CN1907958A (zh)	2007-02-07
EP2277857A3 (fr)	2011-06-01
HRP20120779T1 (hr)	2012-10-31
AP2006003695A0 (en)	2006-08-31
CR8529A (es)	2006-12-07
TW200736199A (en)	2007-10-01
AU2006203342A1 (en)	2007-02-22
WO2007015004A2 (fr)	2007-02-08
CN100448843C (zh)	2009-01-07
PL1752443T3 (pl)	2012-11-30
GT200600346A (es)	2007-02-28
EP1752443A1 (fr)	2007-02-14
AU2006203342B2 (en)	2012-07-19
ES2391406T3 (es)	2012-11-26
DK1752443T3 (da)	2012-10-22
PE20070365A1 (es)	2007-06-02
PT1752443E (pt)	2012-07-25
SI1752443T1 (sl)	2012-10-30
EP1752443B1 (fr)	2012-07-11
SG130110A1 (en)	2007-03-20
UA83720C2 (ru)	2008-08-11
CU20060153A7 (es)	2012-04-15
JO2793B1 (en)	2014-03-15
EA200601273A1 (ru)	2007-02-27
CY1113011T1 (el)	2016-04-13
MA28451B1 (fr)	2007-03-01
CA2555115C (fr)	2013-12-10
MXPA06008789A (es)	2007-02-02
JP4575337B2 (ja)	2010-11-04
FR2889523A1 (fr)	2007-02-09
EP2277857A2 (fr)	2011-01-26
EA011030B1 (ru)	2008-12-30
HK1098128A1 (en)	2007-07-13
IL177173A (en)	2011-10-31
NO20063517L (no)	2007-02-05
AR057715A1 (es)	2007-12-12
ECSP066715A (me)	2007-03-29
CA2555115A1 (fr)	2007-02-03
WO2007015004A3 (fr)	2007-03-22
NZ548864A (en)	2008-03-28
ZA200606453B (en)	2007-12-27
NO336967B1 (no)	2015-12-07
TWI359128B (en)	2012-03-01
BRPI0603059A (pt)	2007-08-14

Publication	Publication Date	Title
PL1752443T3 (pl)	2012-11-30	Nowa postać krystaliczna V agomelatyny, sposób jej wytwarzania i kompozycje farmaceutyczne, które ją zawierają
PL2210872T3 (pl)	2017-07-31	Nowa postać krystaliczna III agomelatyny, sposób jej wytwarzania i kompozycje farmaceutyczne ją zawierające
PL1695709T3 (pl)	2008-10-31	Postać krystaliczna gamma-d chlorowodorku iwabradyny, sposób jej wytwarzania i kompozycje farmaceutyczne zawierające tę postać
PL1695710T3 (pl)	2008-09-30	Postać krystaliczna beta-d chlorowodorku iwabradyny, sposób jej otrzymywania i zawierające je kompozycje farmaceutyczne
SI1695965T1 (sl)	2009-02-28	Beta kristalna oblika ivabradin-hidroklorida in farmacevtski sestavki, ki jo vsebujejo
ME02747B (me)	2010-05-07	Kristalni oblik gama ivabradin hlorhidrata, postupak njegove izrade i farmaceutske smeše koje ga sadrže
IL185353A0 (en)	2008-02-09	Azabicycloalkane derivatives , pharmaceutical compositions containing the same and methods for the preparation thereof
ZA200606455B (en)	2007-12-27	Crystalline form IV of agomelatine, a process for its preparation and pharmaceutical compositions containing it
IL190137A (en)	2015-06-30	Lacquinimod crystalline mixtures, pharmaceutical compositions containing them and ways to prepare them
IL193772A0 (en)	2009-08-03	4-oxoquinoline derivatives,methods for the preparation thereof and pharmaceutical compositions containing the same
PL2036892T3 (pl)	2010-08-31	Pochodne 1,2,4,5-tetrahydro-3H-benzazepin, sposób ich wytwarzania i zawierające je kompozycje farmaceutyczne
HUP0401522A2 (en)	2006-04-28	New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
SI1707564T1 (sl)	2007-12-31	Indanil-piperazinski derivati, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo
PL2231598T3 (pl)	2011-12-30	Nowe pochodne diazeniodiolanów, sposób ich wytwarzania i kompozycje farmaceutyczne je zawierające
HK1126190A1 (en)	2009-08-28	Novel pyridinylaminoalkylene- and pyridinyloxyalkylene-cyclopropanamines, process for the preparation thereof and pharmaceutical compositions containing them
ZA200902413B (en)	2010-07-28	Novel indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
SI1748043T1 (sl)	2008-12-31	Polisubstituirane spojine 1,1-piridiniloksiciklopropanaminov, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo
ZA200805976B (en)	2009-11-25	Novel heterocyclic oxime derivatives, process for the preparation thereof and pharmaceutical compositions containing them
HUP0600847A2 (en)	2009-04-28	Chiral betha aminoacids and their derivatives, process for their preparation pharmaceutical compositions containing the same and use of the compounds
HUP0400812A2 (en)	2006-02-28	Crystalline forms of 2-amino-3-cyano-quinoline derivatives, process for their preparation and pharmaceutical compositions containing them