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HK1068887A1 - Method for the preparation of hexahydro-furo - Google Patents

Method for the preparation of hexahydro-furo

Info

Publication number
HK1068887A1
HK1068887A1 HK05101515.9A HK05101515A HK1068887A1 HK 1068887 A1 HK1068887 A1 HK 1068887A1 HK 05101515 A HK05101515 A HK 05101515A HK 1068887 A1 HK1068887 A1 HK 1068887A1
Authority
HK
Hong Kong
Prior art keywords
furo
hexahydro
preparation
Prior art date
Application number
HK05101515.9A
Other languages
English (en)
Inventor
Bart Rudolf Romanie Kesteleyn
Dominique Louis Nestor Ghislain Surleraux
Peter J L M Quaedflieg
Original Assignee
Tibotec Pharmaceuticals Little
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8180908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1068887(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharmaceuticals Little filed Critical Tibotec Pharmaceuticals Little
Publication of HK1068887A1 publication Critical patent/HK1068887A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK05101515.9A 2001-09-10 2005-02-23 Method for the preparation of hexahydro-furo HK1068887A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203416 2001-09-10
PCT/EP2002/010062 WO2003022853A1 (en) 2001-09-10 2002-09-06 Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol

Publications (1)

Publication Number Publication Date
HK1068887A1 true HK1068887A1 (en) 2005-05-06

Family

ID=8180908

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05101515.9A HK1068887A1 (en) 2001-09-10 2005-02-23 Method for the preparation of hexahydro-furo

Country Status (28)

Country Link
US (1) US7126015B2 (xx)
EP (1) EP1448567B1 (xx)
JP (1) JP4521185B2 (xx)
KR (1) KR100894673B1 (xx)
CN (2) CN100519561C (xx)
AP (1) AP1758A (xx)
AR (1) AR036501A1 (xx)
AT (1) ATE453648T1 (xx)
AU (1) AU2002333809C1 (xx)
BR (1) BRPI0212341B8 (xx)
CA (1) CA2459168C (xx)
CY (1) CY1109974T1 (xx)
DE (1) DE60234952D1 (xx)
DK (1) DK1448567T3 (xx)
EA (1) EA010883B1 (xx)
ES (1) ES2338538T3 (xx)
HK (1) HK1068887A1 (xx)
HR (1) HRP20040320B1 (xx)
HU (1) HU229505B1 (xx)
IL (2) IL160166A0 (xx)
MX (1) MXPA04002247A (xx)
NO (1) NO328934B1 (xx)
NZ (1) NZ531641A (xx)
PL (1) PL224030B1 (xx)
PT (1) PT1448567E (xx)
SI (1) SI21463B (xx)
WO (1) WO2003022853A1 (xx)
ZA (1) ZA200401501B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005533821A (ja) * 2002-06-27 2005-11-10 スミスクライン ビーチャム コーポレーション （３α，３α／β，６α／β）ヘキサヒドロフロ［２，３−ｂ］フラン−３−オールの立体異性体の調製
EP1589018A4 (en) * 2002-12-27 2007-03-14 Sumitomo Chemical Co PROCESS FOR PRODUCING A DERIVATIVE OF HEXAHYDROFURANOL, INTERMEDIATE THEREOF AND PROCESS FOR PRODUCING THE SAME
US7772411B2 (en) 2003-12-23 2010-08-10 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
TWI383975B (zh) * 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法
JP5549898B2 (ja) * 2006-03-31 2014-07-16 独立行政法人産業技術総合研究所 ５−ヒドロキシメチル−２−フルフラールの製造法
CN102432621B (zh) 2006-11-09 2016-02-17 爱尔兰詹森科学公司 六氢呋喃并[2,3-b]呋喃-3-醇的制备方法
CN101024646B (zh) * 2007-02-06 2010-07-14 启东东岳药业有限公司 4-甲氧基呋喃并呋喃-2-酮的纯化方法
US8076513B2 (en) 2007-04-27 2011-12-13 Tibotec Pharmaceuticals Ltd. Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
AR073248A1 (es) 2008-09-01 2010-10-20 Tibotec Pharm Ltd Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
US20110257111A1 (en) * 2008-10-24 2011-10-20 Harbeson Scott L Hydroxyethlamino Sulfonamide Derivatives
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
EP2493891A2 (en) 2009-10-30 2012-09-05 Lupin Limited A novel process for preparation of darunavir and darunavir ethanolate of fine particle size
MX2012008627A (es) 2010-01-28 2012-09-21 Mapi Pharma Ltd Proceso para la preparacion de darunavir e intermedios de darunavir.
LT2643326T (lt) 2010-11-23 2017-02-27 Mylan Laboratories, Limited (3r,3as,6ar)-heksahidrofuro[2,3-b]furan-3-olio gavimo būdas
US8802724B2 (en) 2010-11-30 2014-08-12 Purdue Research Foundation Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans
WO2014016660A2 (en) 2012-07-24 2014-01-30 Laurus Labs Private Limited A process for preparation of darunavir
CN104520262A (zh) * 2012-08-09 2015-04-15 住友化学株式会社 六氢呋喃并呋喃醇衍生物的制造方法
CN103864813B (zh) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
EP3313847A4 (en) * 2015-06-25 2019-04-24 MSN Laboratories Private Limited PROCESS FOR PREPARING (3R, 3AS, 6AR) HEXAHYDROFURO [2,3-B] FURAN-3-YL ESTER OF [(1S, 2R) -3 - [[(4-AMINOPHENYL) SULFONYL] (2-METHYLPROPYL) ACID ) AMINO] -2-HYDROXY-1- (PHENYLMETHYL) PROPYL] -CARBAMIC AND ITS AMORPHOUS FORM
WO2017041228A1 (zh) * 2015-09-08 2017-03-16 浙江九洲药业股份有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN110423228B (zh) * 2016-02-05 2023-01-10 成都博腾药业有限公司 一种制备地瑞那韦中间体的方法
US10407438B2 (en) 2016-10-27 2019-09-10 Gilead Sciences, Inc. Crystalline forms of darunavir
CN106928248B (zh) * 2017-02-04 2019-01-04 青岛科技大学 一种制备(3R,3aS,6aR)六氢呋喃并[2,3-b]呋喃-3-醇的方法
CN110272398B (zh) 2018-03-16 2022-11-29 江苏瑞科医药科技有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN114853774A (zh) * 2022-06-24 2022-08-05 盐城迪赛诺制药有限公司 一种达卢那韦关键中间体的制备方法
CN115557964A (zh) * 2022-10-18 2023-01-03 启东东岳药业有限公司 一种药物化合物的制备方法

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US5281420A (en) * 1992-05-19 1994-01-25 The Procter & Gamble Company Solid dispersion compositions of tebufelone
WO1994026749A1 (en) * 1993-05-14 1994-11-24 Merck & Co., Inc. Hiv protease inhibitors
DE69415326T2 (de) 1993-08-24 1999-06-02 G.D. Searle & Co., Chicago, Ill. Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
RU2089545C1 (ru) * 1994-09-28 1997-09-10 Ярославский государственный технический университет Способ получения 2-метил-2-этил-1,3-диоксолан-4-ил-метилметакрилата
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Die gastrointestinale Durchblutung fördernde Arzneimittel
GB2355195B (en) * 1997-01-30 2001-09-12 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
ES2362404T5 (es) 1998-06-23 2015-11-25 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Ensayo de aptitud y métodos para reducir la resistencia del VIH a terapia
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
KR100336090B1 (ko) * 1998-06-27 2002-05-27 윤승원 오일, 지방산 또는 이들의 혼합물을 함유한 난용성 약물의 고형분산제제
DE19906310A1 (de) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Arzneimittel zur Behandlung von Bluthochdruck
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
SK287153B6 (sk) * 1999-10-06 2010-01-07 Tibotec Pharmaceuticals Ltd. Hexahydrofuro[2,3-b]furan-3-yl-N-{3-[(1,3-benzodioxol-5- ylsulfonyl)(izobutyl)amino]1-benzyl-2-hydroxypropyl}karbamát, jeho použitie a farmaceutický prípravok s jeho obsahom

Also Published As

Publication number Publication date
AR036501A1 (es) 2004-09-15
EA010883B1 (ru) 2008-12-30
DK1448567T3 (da) 2010-04-26
ES2338538T3 (es) 2010-05-10
EP1448567A1 (en) 2004-08-25
HU229505B1 (hu) 2014-01-28
HUP0402140A3 (en) 2007-05-29
PL367817A1 (en) 2005-03-07
IL160166A0 (en) 2004-07-25
SI21463A (sl) 2004-10-31
AU2002333809B8 (en) 2008-07-03
US7126015B2 (en) 2006-10-24
AP1758A (en) 2007-07-30
US20040249175A1 (en) 2004-12-09
AU2002333809C1 (en) 2009-02-05
KR20040029425A (ko) 2004-04-06
BRPI0212341B8 (pt) 2021-05-25
AU2002333809B9 (en) 2008-06-26
PT1448567E (pt) 2010-03-12
CN1553915A (zh) 2004-12-08
EA200400430A1 (ru) 2004-08-26
EP1448567B1 (en) 2009-12-30
HUP0402140A2 (hu) 2005-02-28
CY1109974T1 (el) 2014-09-10
NO328934B1 (no) 2010-06-21
SI21463B (sl) 2011-08-31
IL160166A (en) 2012-05-31
HRP20040320B1 (hr) 2012-11-30
CA2459168A1 (en) 2003-03-20
ZA200401501B (en) 2005-07-27
MXPA04002247A (es) 2005-09-07
DE60234952D1 (de) 2010-02-11
JP4521185B2 (ja) 2010-08-11
CN100519561C (zh) 2009-07-29
PL224030B1 (pl) 2016-11-30
JP2005502707A (ja) 2005-01-27
NO20041434L (no) 2004-06-10
KR100894673B1 (ko) 2009-04-24
WO2003022853A1 (en) 2003-03-20
BR0212341A (pt) 2004-07-27
ATE453648T1 (de) 2010-01-15
CN101172980A (zh) 2008-05-07
CN101172980B (zh) 2011-11-16
AP2004002981A0 (en) 2004-03-31
HRP20040320A2 (en) 2005-04-30
AU2002333809B2 (en) 2008-02-28
NZ531641A (en) 2005-08-26
CA2459168C (en) 2014-01-28
BRPI0212341B1 (pt) 2019-04-02

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20220905