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HK1054183B - 含有雷帕霉素衍生物的藥學組合物 - Google Patents

含有雷帕霉素衍生物的藥學組合物

Info

Publication number
HK1054183B
HK1054183B HK03104827.8A HK03104827A HK1054183B HK 1054183 B HK1054183 B HK 1054183B HK 03104827 A HK03104827 A HK 03104827A HK 1054183 B HK1054183 B HK 1054183B
Authority
HK
Hong Kong
Prior art keywords
pharmaceutical compositions
compositions containing
phosphatidylglycerol
sub
salt
Prior art date
Application number
HK03104827.8A
Other languages
English (en)
Other versions
HK1054183A1 (en
Inventor
Harry Tiemessen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1054183A1 publication Critical patent/HK1054183A1/xx
Publication of HK1054183B publication Critical patent/HK1054183B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
HK03104827.8A 1996-01-19 1999-02-05 含有雷帕霉素衍生物的藥學組合物 HK1054183B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9601120.0A GB9601120D0 (en) 1996-01-19 1996-01-19 Organic compounds
HK99100514A HK1015277A1 (en) 1996-01-19 1999-02-05 [3'-desoxy-3-oxo-mebmt]1-[val]2-ciclosporin-containing emulsion pharmaceutical compositions

Publications (2)

Publication Number Publication Date
HK1054183A1 HK1054183A1 (en) 2003-11-21
HK1054183B true HK1054183B (zh) 2006-07-28

Family

ID=10787276

Family Applications (3)

Application Number Title Priority Date Filing Date
HK03104828.7A HK1053973B (zh) 1996-01-19 1999-02-05 含有雷帕霉素衍生物的藥學組合物
HK03104827.8A HK1054183B (zh) 1996-01-19 1999-02-05 含有雷帕霉素衍生物的藥學組合物
HK99100514A HK1015277A1 (en) 1996-01-19 1999-02-05 [3'-desoxy-3-oxo-mebmt]1-[val]2-ciclosporin-containing emulsion pharmaceutical compositions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK03104828.7A HK1053973B (zh) 1996-01-19 1999-02-05 含有雷帕霉素衍生物的藥學組合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK99100514A HK1015277A1 (en) 1996-01-19 1999-02-05 [3'-desoxy-3-oxo-mebmt]1-[val]2-ciclosporin-containing emulsion pharmaceutical compositions

Country Status (14)

Country Link
US (2) US6239102B1 (zh)
EP (4) EP0874621B1 (zh)
JP (2) JP4077386B2 (zh)
KR (1) KR100485146B1 (zh)
AT (4) ATE304842T1 (zh)
AU (1) AU1543497A (zh)
CA (2) CA2678707A1 (zh)
DE (3) DE69721729T2 (zh)
DK (4) DK1273289T3 (zh)
ES (4) ES2247245T3 (zh)
GB (1) GB9601120D0 (zh)
HK (3) HK1053973B (zh)
PT (2) PT1679064E (zh)
WO (1) WO1997025977A1 (zh)

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US6284268B1 (en) 1997-12-10 2001-09-04 Cyclosporine Therapeutics Limited Pharmaceutical compositions containing an omega-3 fatty acid oil
DE19810655A1 (de) * 1998-03-12 1999-09-16 Univ Eberhard Karls Arzneimittel mit einem Gehalt an Ciclosporin
TW537894B (en) 1998-05-26 2003-06-21 Novartis Ag A spontaneously dispersible pharmaceutical composition comprising a piperidine substance P antagonist
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US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
DE60015516T2 (de) * 1999-04-30 2005-12-01 Sucampo Ag Verwendung von makroliden zur behandlung von trockenen augen
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CA2240339A1 (en) 1997-07-24
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JP2000503655A (ja) 2000-03-28
DE69721729D1 (de) 2003-06-12
HK1054183A1 (en) 2003-11-21
PT1679064E (pt) 2011-07-25
WO1997025977A1 (en) 1997-07-24
EP1679064B1 (en) 2011-05-25
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EP1273289A1 (en) 2003-01-08
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