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HK1050518A1 - Shortened synthesis of 3,3-diarylpropylamine derivatives - Google Patents

Shortened synthesis of 3,3-diarylpropylamine derivatives

Info

Publication number
HK1050518A1
HK1050518A1 HK03102705A HK03102705A HK1050518A1 HK 1050518 A1 HK1050518 A1 HK 1050518A1 HK 03102705 A HK03102705 A HK 03102705A HK 03102705 A HK03102705 A HK 03102705A HK 1050518 A1 HK1050518 A1 HK 1050518A1
Authority
HK
Hong Kong
Prior art keywords
phenylchromane
oxo
alkyl
formula
image
Prior art date
Application number
HK03102705A
Other languages
English (en)
Inventor
Claus Meese
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of HK1050518A1 publication Critical patent/HK1050518A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/66—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK03102705A 2000-06-14 2003-04-14 Shortened synthesis of 3,3-diarylpropylamine derivatives HK1050518A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10028443A DE10028443C1 (de) 2000-06-14 2000-06-14 Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen
PCT/EP2001/006577 WO2001096279A1 (de) 2000-06-14 2001-06-11 Verkürzte synthese von 3,3-diarylpropylamin-derivaten

Publications (1)

Publication Number Publication Date
HK1050518A1 true HK1050518A1 (en) 2003-06-27

Family

ID=7645152

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03102705A HK1050518A1 (en) 2000-06-14 2003-04-14 Shortened synthesis of 3,3-diarylpropylamine derivatives

Country Status (24)

Country Link
US (1) US6809214B2 (es)
EP (1) EP1289929B1 (es)
JP (2) JP4002180B2 (es)
KR (1) KR100580568B1 (es)
CN (1) CN1234679C (es)
AT (1) ATE368640T1 (es)
AU (2) AU2001269063B2 (es)
BR (1) BR0111266A (es)
CA (1) CA2412047C (es)
CZ (1) CZ20023665A3 (es)
DE (2) DE10028443C1 (es)
ES (1) ES2290153T3 (es)
HK (1) HK1050518A1 (es)
HU (1) HUP0204563A3 (es)
IL (2) IL151595A0 (es)
IS (1) IS6534A (es)
MX (1) MXPA02009643A (es)
NO (1) NO20025967L (es)
NZ (1) NZ521265A (es)
PL (1) PL360845A1 (es)
RU (1) RU2270188C2 (es)
SK (1) SK142003A3 (es)
WO (1) WO2001096279A1 (es)
ZA (1) ZA200207204B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
WO2005012227A2 (en) * 2003-08-05 2005-02-10 Ranbaxy Laboratories Limited Process for preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, a metabolite of tolterodine
JP4513535B2 (ja) * 2004-12-03 2010-07-28 住友化学株式会社 トルテロジンの製造方法
EP1836156A1 (en) * 2005-01-10 2007-09-26 Teva Gyogyszergyar Reszvenytarsasag Substantially pure tolterodine tartrate and process for preparing thereof
WO2007137799A1 (en) * 2006-05-31 2007-12-06 Schwarz Pharma Ltd. New synthesis of substituted hydroxymethyl phenols
WO2007144097A1 (en) * 2006-06-12 2007-12-21 Schwarz Pharma Ag New chiral intermediate, process for producing the same and its use in the manufacture of tolterodine, fesoterodine, or the active metabolite thereof
SI2281801T1 (sl) * 2009-07-27 2014-04-30 Crystal Pharma, S.A.U. Postopek za pridobivanje 3,3-diphenilpropilamina
IT1396373B1 (it) * 2009-10-29 2012-11-19 Dipharma Francis Srl Procedimento per la preparazione di fesoterodina.
EP2364966A1 (en) 2010-03-09 2011-09-14 LEK Pharmaceuticals d.d. Process for preparation of 3-(2-hydroxy-5-substituted phenyl)-3-phenylpropylamines, intermediates for making hydroxytolterodine
WO2011141932A2 (en) 2010-05-11 2011-11-17 Intas Pharmaceuticals Limited Process for preparation of phenolic monoesters of hydroxymethyl phenols
IT1401451B1 (it) 2010-06-10 2013-07-26 Chemi Spa Nuovo processo di preparazione di 2-idrossi-4-fenil-3,4-diidro-2h-cromen-6-il-metanolo e (r)-2-[3-(diisopropilammino)-1-fenilpropil]-4-(idrossimetil)fenolo.
WO2011158257A1 (en) 2010-06-18 2011-12-22 Panacea Biotec Ltd Preparation process of fesoterodine and intermediates
IT1403094B1 (it) 2010-12-09 2013-10-04 Dipharma Francis Srl Procedimento per la preparazione di fesoterodina o un suo sale
CA2873721C (en) 2012-05-04 2021-06-22 Crystal Pharma, S.A.U. Process for the preparation of optically active 3,3-diphenylpropylamines
EP2760822B1 (en) 2012-06-14 2016-03-23 ratiopharm GmbH Desfesoterodine salts
ITMI20121232A1 (it) 2012-07-16 2014-01-17 Cambrex Profarmaco Milano Srl Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati
CN103193747A (zh) * 2013-04-18 2013-07-10 中国药科大学 一种富马酸弗斯特罗定中间体的制备方法
WO2017137955A1 (en) 2016-02-14 2017-08-17 Celestis Pharmaceuticals Pvt. Ltd. Novel (r) and rac 3-(2-(allyloxy)-5-methylphenyl)-n,n-diisopropyl-3- phenylpropan-1-amine and its use for synthesis of (r) and rac-2-(3- (diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8800207D0 (sv) * 1988-01-22 1988-01-22 Kabivitrum Ab Nya aminer, deras anvendning och framstellning
SE9203318D0 (sv) * 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
KR20000057548A (ko) * 1996-12-13 2000-09-25 알프레드 엘. 미첼슨 광학적 전송물질 및 결합재
SE9701144D0 (sv) * 1997-03-27 1997-03-27 Pharmacia & Upjohn Ab Novel compounds, their use and preparation
JP3913329B2 (ja) * 1997-09-11 2007-05-09 株式会社クラレ （±）−クロマンカルボン酸の光学分割法
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE19955190A1 (de) * 1999-11-16 2001-06-21 Sanol Arznei Schwarz Gmbh Stabile Salze neuartiger Derivate von 3,3-Diphenylpropylaminen

Also Published As

Publication number Publication date
DE10028443C1 (de) 2002-05-29
NZ521265A (en) 2004-06-25
IL151595A (en) 2007-03-08
RU2270188C2 (ru) 2006-02-20
DE50112793D1 (de) 2007-09-13
KR20020093870A (ko) 2002-12-16
JP4002180B2 (ja) 2007-10-31
AU2001269063B2 (en) 2005-03-24
ATE368640T1 (de) 2007-08-15
EP1289929A1 (de) 2003-03-12
SK142003A3 (en) 2003-04-01
WO2001096279A1 (de) 2001-12-20
CN1234679C (zh) 2006-01-04
US20030212292A1 (en) 2003-11-13
JP2007231024A (ja) 2007-09-13
HUP0204563A2 (en) 2003-05-28
ES2290153T3 (es) 2008-02-16
CA2412047C (en) 2008-09-09
NO20025967D0 (no) 2002-12-12
US6809214B2 (en) 2004-10-26
BR0111266A (pt) 2003-12-16
KR100580568B1 (ko) 2006-05-16
CN1429197A (zh) 2003-07-09
NO20025967L (no) 2002-12-12
IL151595A0 (en) 2003-04-10
ZA200207204B (en) 2003-05-23
MXPA02009643A (es) 2003-03-10
HUP0204563A3 (en) 2004-12-28
EP1289929B1 (de) 2007-08-01
JP2004503520A (ja) 2004-02-05
AU6906301A (en) 2001-12-24
IS6534A (is) 2002-08-30
CA2412047A1 (en) 2001-12-20
PL360845A1 (en) 2004-09-20
CZ20023665A3 (cs) 2003-02-12

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110611