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GT201300207A - Derivados de heteroarilo como moduladores de nachr alfa 7 - Google Patents

Derivados de heteroarilo como moduladores de nachr alfa 7

Info

Publication number
GT201300207A
GT201300207A GT201300207A GT201300207A GT201300207A GT 201300207 A GT201300207 A GT 201300207A GT 201300207 A GT201300207 A GT 201300207A GT 201300207 A GT201300207 A GT 201300207A GT 201300207 A GT201300207 A GT 201300207A
Authority
GT
Guatemala
Prior art keywords
deteriority
analogs
heteroarilo
nachr
alfa
Prior art date
Application number
GT201300207A
Other languages
English (en)
Inventor
Neelima Sinha
Gourhari Jana
Sachchidanand Sachchidanand
Sanjay Pralhad Kurhade
Navnath Popat Karche
Anil Kashiram Hajare
Ajay Ramchandra Tilekar
Venkata P Palle
Rajender Kumar Kamboj
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45873193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT201300207(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of GT201300207A publication Critical patent/GT201300207A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

SE DESCRIBE UN COMPUESTO DE FÓRMULA (I), EN LA QUE Z, M Y R1-R6 SON COMO SE DESCRIBE EN EL PRESENTE DOCUMENTO, COMO UN MODULADOR DE LOS RECEPTORES NICOTÍNICOS DE LA ACETILCOLINA EN PARTICULAR EL SUBTIPO A7, EN UN SUJETO EN NECESIDAD DEL MISMO, ASÍ COMO ANÁLOGOS, PROFÁRMACOS, ISOTÓPICAMENTE ANÁLOGOS SUSTITUIDOS, METABOLITOS, SALES FARMACÉUTICAMENTE ACEPTABLES, POLIMORFOS, SOLVATOS, ISÓMEROS, CLATRATOS, Y CO-CRISTALES, PARA SU USO YA SEA SOLOS O EN COMBINACIONES CON OTROS MEDICAMENTOS ADECUADOS Y COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN TALES COMPUESTOS Y ANÁLOGOS.TAMBIÉN SE DESCRIBE UN PROCESO DE PREPARACIÓN DE LOS COMPUESTOS Y LOS USOS PREVISTOS DE LOS MISMOS EN TERAPIA, EN PARTICULAR EN LA PROFILAXIS Y TERAPIA DE TRASTORNOS TALES COMO LA ENFERMEDAD DE ALZHEIMER, DETERIORO COGNITIVO LEVE, DEMENCIA SENIL, Y SIMILARES.
GT201300207A 2011-02-23 2013-08-22 Derivados de heteroarilo como moduladores de nachr alfa 7 GT201300207A (es)

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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA34957B1 (fr) 2011-02-23 2014-03-01 Lupin Ltd Derives heteroaryle a titre modulateurs des nachr alpha 7
AU2013229177B2 (en) 2012-03-06 2017-03-23 Lupin Limited Thiazole derivatives as alpha 7 nAChR modulators
TWI663171B (zh) * 2012-09-28 2019-06-21 日商武田藥品工業股份有限公司 噻吩并嘧啶衍生物之製造方法
WO2014072957A1 (en) 2012-11-12 2014-05-15 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
EP2945941B1 (en) 2013-01-16 2016-12-07 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
CN105051024A (zh) * 2013-03-13 2015-11-11 鲁平有限公司 作为α7烟碱型乙酰胆碱受体的调节剂的吡咯衍生物
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
WO2014203150A1 (en) 2013-06-17 2014-12-24 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
WO2016100184A1 (en) 2014-12-16 2016-06-23 Forum Pharmaceuticals, Inc. Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
JP2018516973A (ja) 2015-06-10 2018-06-28 フォーラム・ファーマシューティカルズ・インコーポレイテッドＦｏｒｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． α７−ニコチン性アセチルコリン受容体のアゴニストとしてのアミノベンゾイソオキサゾール化合物
JP2018523707A (ja) 2015-08-12 2018-08-23 アクソバント サイエンシズ ゲーエムベーハー α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換アミノベンゾイソオキサゾール化合物
ES2901197T3 (es) * 2016-03-22 2022-03-21 Merck Sharp & Dohme Moduladores alostéricos de los receptores nicotínicos de la acetilcolina
CA3102777A1 (en) * 2018-06-07 2019-12-12 The Regents Of The University Of Michigan Prc1 inhibitors and methods of treatment therewith
PE20210183A1 (es) * 2018-07-05 2021-02-02 Bayer Ag Tiofenocarboxamidas sustituidas y analogos de las mismas
EP3994130B1 (en) 2019-07-03 2024-07-10 Bayer Aktiengesellschaft Substituted thiophene carboxamides and derivatives thereof as microbicides
CR20220294A (es) 2019-12-20 2022-08-03 Bayer Ag Tiofenocarboxamidas sustituidas y sus derivados

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953596A (en) 1973-06-14 1976-04-27 Ici United States Inc. 8-Oxa-3-azabicyclo(3.2.1)octane analgesic compositions and method of alleviating pain in animals
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5608082A (en) 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
CA2301742C (en) 1997-09-12 2004-05-18 Richard Friesen 2,3,5-trisubstituted pyridines as inhibitors of cyclooxygenase-2
EP1311505A2 (en) * 2000-08-21 2003-05-21 PHARMACIA & UPJOHN COMPANY Quinuclidine-substituted heteroaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands )
US7514452B2 (en) 2002-02-01 2009-04-07 Dainippon Pharmaceutical Co., Ltd 2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same
FR2840303B1 (fr) 2002-05-31 2005-07-15 Rhodia Chimie Sa Procede d'arylation ou de vinylation ou d'alcylynation d'un compose nucleophile
SE0201938D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab New process
DE10244810A1 (de) 2002-09-26 2004-04-08 Bayer Ag Neue Morpholin-überbrückte Indazolderivate
US7129235B2 (en) 2003-07-11 2006-10-31 Abbott Laboratories Amides useful for treating pain
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
GB0403038D0 (en) 2004-02-11 2004-03-17 Novartis Ag Organic compounds
CN1926098A (zh) 2004-03-29 2007-03-07 神经研究公司 新的脲衍生物及其医药应用
ITTO20040264A1 (it) 2004-04-28 2004-07-28 Rotta Res Lab Spa Nuovi derivati pirrolici ad attivita' angiotensina-ii antagonista
EP1790640A4 (en) 2004-09-09 2009-07-29 Chugai Pharmaceutical Co Ltd NEW IMIDAZOLIDINE DERIVATIVE AND APPLICATION THEREOF
US20060142349A1 (en) 2004-12-23 2006-06-29 Pfizer Inc Methods of modulating the activities of alpha-7 nicotinic acetylcholine receptor
JP2008530171A (ja) 2005-02-16 2008-08-07 ノイロサーチ アクティーゼルスカブ 新規なジアザ二環系アリール誘導体及びそれらの医療上の使用
FR2885616B1 (fr) 2005-05-12 2007-06-22 Servier Lab Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1910328A1 (en) * 2005-06-29 2008-04-16 AstraZeneca AB Thiophene-2-carboxamide derivatives as alpha 7 nicotinic receptor modulators
AU2006278592A1 (en) 2005-08-04 2007-02-15 Apogee Biotechnology Corporation Sphingosine kinase inhibitors and methods of their use
EP1926719B1 (en) 2005-09-13 2017-05-31 Janssen Pharmaceutica NV 2-aniline-4-aryl substituted thiazole derivatives
ES2452031T3 (es) 2006-02-03 2014-03-31 Eli Lilly & Company Compuestos y procedimientos para modular receptores FX
DE602007004307D1 (de) 2006-02-16 2010-03-04 Neurosearch As Enantiomerenreine chinuclidinyloxy-pyridazine und ihre verwendung als nikotin-acetylcholin-rezeptorliganden
JO3019B1 (ar) 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
US7741364B2 (en) 2006-06-27 2010-06-22 Abbott Laboratories Pyrrole derivatives and their methods of use
CN101479262A (zh) 2006-06-27 2009-07-08 艾博特公司 噻唑啉和唑啉衍生物及其应用方法
CA2668371A1 (en) 2006-11-02 2008-05-15 Merck & Co., Inc. Heterocyclyl-substituted anti-hypercholesterolemic compounds
US20080287479A1 (en) 2006-12-20 2008-11-20 Pfizer Inc Inhibitors of serine palmitoyltransferase
MX2010001135A (es) 2007-08-08 2010-03-09 Neurosearch As Nuevos derivados de 1,2,3-triazol, utiles como modulares de receptores de acetilcolina nicotinicos.
GB0718735D0 (en) 2007-09-25 2007-11-07 Prolysis Ltd Antibacterial agents
AU2008307195B2 (en) 2007-10-04 2012-11-22 F. Hoffmann-La Roche Ag Cyclopropyl aryl amide derivatives and uses thereof
CA2701214C (en) 2007-10-04 2016-08-02 F. Hoffmann-La Roche Ag Tetrazole-substituted aryl amide derivatives and uses thereof
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
KR101564303B1 (ko) 2008-03-19 2015-11-06 얀센 파마슈티카 엔.브이. 니코틴성 아세틸콜린 수용체 조절제로서의 삼치환된 1,2,4-트리아졸
US7786171B2 (en) 2008-04-04 2010-08-31 Abbott Laboratories Amide derivatives as positive allosteric modulators and methods of use thereof
AU2009237649B2 (en) 2008-04-17 2012-07-26 Proximagen Limited Indole modulators of the alpha 7 nicotinic acetylcholine receptor
EP2280945B1 (en) 2008-05-09 2014-09-03 Janssen Pharmaceutica, N.V. Trisubstituted pyrazoles as acetylcholine receptor modulators
WO2010083444A1 (en) 2009-01-15 2010-07-22 Anvyl, Llc Alpha7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof
WO2010120854A1 (en) 2009-04-15 2010-10-21 Glaxosmithkline Llc Chemical compounds
WO2010130768A1 (en) 2009-05-14 2010-11-18 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.1]octane derivatives useful as nicotinic acetylcholine receptor modulators
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
JO3078B1 (ar) 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
SG192078A1 (en) 2011-02-03 2013-08-30 Lupin Ltd Pyrrole derivatives used as modulators of alpha7 nachr
MA34957B1 (fr) 2011-02-23 2014-03-01 Lupin Ltd Derives heteroaryle a titre modulateurs des nachr alpha 7
EP2691368A1 (en) 2011-03-31 2014-02-05 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
US8946432B2 (en) 2011-07-05 2015-02-03 Lupin Limited Biaryl derivatives as nAChR modulators

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