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GT200200195A - Tetrahidroquinolinas - Google Patents

Tetrahidroquinolinas

Info

Publication number
GT200200195A
GT200200195A GT200200195A GT200200195A GT200200195A GT 200200195 A GT200200195 A GT 200200195A GT 200200195 A GT200200195 A GT 200200195A GT 200200195 A GT200200195 A GT 200200195A GT 200200195 A GT200200195 A GT 200200195A
Authority
GT
Guatemala
Prior art keywords
tetrahydroquinolins
cholesterol
hypertrigliceridemias
hdlcolesterina
aterosclerosis
Prior art date
Application number
GT200200195A
Other languages
English (en)
Inventor
Heike Gielen
Siegfried Goldmann
Joerg Keldenich
Holger Paulsen
Carsten Schmeck
Stephan Siegel
Hilmar Bischoff
Martin Raabe
Delf Schmidt
Christiane Faeste
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200200195A publication Critical patent/GT200200195A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A TETRAHIDROQUINOLINAS DE FORMULA GENERAL (I) EN DONDE A,B, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON INHIBIDORES ALTAMENTE EFICACES DE LAS PROTEINAS DE TRANSFERENCIA DE ESTER DE COLESTERINA (CETP) QUE POR LA INHIBICION ESTIMULAN EL TRANSPORTE INVERSO DE COLESTERINA EN LA SANGRE AUMENTANDO SIMULTANEAMENTE EL NIVEL DE HDLCOLESTERINA POR LO QUE SON DE UTILIDAD EN CUADROS DE HIPOLIPOPROTEINEMIA, DISLIPIDEMIAS, HIPERTRIGLICERIDEMIAS, ATEROSCLEROSIS.
GT200200195A 2001-10-01 2002-09-27 Tetrahidroquinolinas GT200200195A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10148436A DE10148436A1 (de) 2001-10-01 2001-10-01 Tetrahydrochinoline

Publications (1)

Publication Number Publication Date
GT200200195A true GT200200195A (es) 2003-08-22

Family

ID=7701007

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200200195A GT200200195A (es) 2001-10-01 2002-09-27 Tetrahidroquinolinas

Country Status (12)

Country Link
US (1) US20050043341A1 (es)
EP (1) EP1434581A1 (es)
JP (1) JP2005508341A (es)
AR (1) AR036583A1 (es)
CA (1) CA2462030A1 (es)
DE (1) DE10148436A1 (es)
DO (1) DOP2002000457A (es)
GT (1) GT200200195A (es)
HN (1) HN2002000278A (es)
PE (1) PE20030604A1 (es)
UY (1) UY27458A1 (es)
WO (1) WO2003028727A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ569469A (en) 2003-09-26 2010-03-26 Japan Tobacco Inc Method of inhibiting remnant lipoprotein production
EA200600737A1 (ru) 2003-10-08 2006-10-27 Эли Лилли Энд Компани Соединения и способы для лечения дислипидемии
KR20070007112A (ko) 2004-03-26 2007-01-12 일라이 릴리 앤드 캄파니 이상지혈증 치료를 위한 화합물 및 방법
KR20070090248A (ko) * 2004-12-18 2007-09-05 바이엘 헬스케어 아게 4-시클로알킬-치환된 테트라히드로퀴놀린 유도체 및 그의약제로서의 용도
EP1828136A1 (de) * 2004-12-18 2007-09-05 Bayer HealthCare AG (5s)-3-[(s)-fluor(4-trifluoromethylphenyl)methyl]-5,6,7,8-tetrahydrochinolin-5-ol derivate und ihre verwendung als cetp-inhibitoren
DE102006012548A1 (de) 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
CN101096363B (zh) * 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
US20080145498A1 (en) * 2006-12-14 2008-06-19 Kraft Foods Holdings, Inc. Texture and shape control process for acidified food products
NZ587748A (en) * 2008-03-05 2012-01-12 Boehringer Ingelheim Int Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
CA2790643A1 (en) * 2010-02-19 2011-08-25 Boehringer Ingelheim International Gmbh Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
MY158199A (en) 2010-07-09 2016-09-15 Daiichi Sankyo Co Ltd Substituted pyridine compound
EP2760868B1 (en) 2011-08-17 2018-04-25 Boehringer Ingelheim International GmbH Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
JP6097225B2 (ja) * 2012-01-06 2017-03-15 第一三共株式会社 置換ピリジン化合物の酸付加塩
WO2016037534A1 (en) * 2014-09-09 2016-03-17 Boehringer Ingelheim International Trading (Shanghai) Co. Ltd. Novel process for preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP970330B1 (en) * 1996-07-08 2004-06-30 Bayer Ag Cycloalkano pyridines
MA24643A1 (fr) * 1997-09-18 1999-04-01 Bayer Ag Tetrahydro-naphtalenes substitues et composes analogues
DE19741051A1 (de) * 1997-09-18 1999-03-25 Bayer Ag Hetero-Tetrahydrochinoline
DE19741399A1 (de) * 1997-09-19 1999-03-25 Bayer Ag Tetrahydrochinoline

Also Published As

Publication number Publication date
EP1434581A1 (de) 2004-07-07
US20050043341A1 (en) 2005-02-24
JP2005508341A (ja) 2005-03-31
WO2003028727A9 (de) 2003-11-13
UY27458A1 (es) 2003-04-30
PE20030604A1 (es) 2003-09-07
WO2003028727A1 (de) 2003-04-10
DOP2002000457A (es) 2003-04-15
DE10148436A1 (de) 2003-04-17
AR036583A1 (es) 2004-09-15
CA2462030A1 (en) 2003-04-10
HN2002000278A (es) 2002-12-20

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