GB872300A - Improvements in and relating to new derivatives of azabicyclohexane and the manufacture thereof - Google Patents
Improvements in and relating to new derivatives of azabicyclohexane and the manufacture thereofInfo
- Publication number
- GB872300A GB872300A GB33521/57A GB3352157A GB872300A GB 872300 A GB872300 A GB 872300A GB 33521/57 A GB33521/57 A GB 33521/57A GB 3352157 A GB3352157 A GB 3352157A GB 872300 A GB872300 A GB 872300A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- methyl
- methoxyphenyl
- ethyl
- hydrazone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Abstract
The invention comprises azabicyclohexane derivatives of the general formula (I) <FORM:0872300/IV (b)/1> (wherein R is an alkyl group having from one to five carbon atoms, Ar is a phenyl radical which may be substituted by halogen atoms or alkyl or alkoxy groups having one to four carbon atoms, or Ar2 is an o-biphenylene radical), together with their preparation by reacting a diaryldiazomethane of the formula Ar2CN2 with an N-alkylmaleimide of the formula: <FORM:0872300/IV (b)/2> and if necessary heating the resulting pyrazoline. This heating may take place concurrently with the first step, when the compound (I) is isolated directly. Examples describe the preparation of 6,6-diphenyl-3-methyl -, 6,6 - diphenyl - 3 - ethyl -, 6,6 - bis - (p-methoxyphenyl)-3-ethyl-, 6,6-bis(p-methoxyphenyl-3-methyl-, 6,6-o-biphenylene-3-methyl-, 6,6-bis-(p-tolyl)-3-methyl- and 6,6-bis-(p-chlorophenyl) - 3 - ethyl - 2,4 - dioxo - 3 - azabicyclo [3.1.0] hexane. Diphenyldiazomethane, bis - (p - methoxyphenyl)diazomethane and 9-diazofluorene were obtained from benzophenone hydrazone, p,p1-dimethoxybenzophenone hydrazone and fluorenone hydrazone respectively.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US872300XA | 1956-10-26 | 1956-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB872300A true GB872300A (en) | 1961-07-05 |
Family
ID=22203896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33521/57A Expired GB872300A (en) | 1956-10-26 | 1957-10-28 | Improvements in and relating to new derivatives of azabicyclohexane and the manufacture thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB872300A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3166571A (en) * | 1962-06-06 | 1965-01-19 | American Cyanamid Co | 1-phenyl-1, 2-cyclopropane dicarboximides |
| EP1140828B1 (en) * | 1998-12-23 | 2006-08-09 | Pfizer Limited | 3-azabicyclo¬3.1.0|hexane derivatives as opiate receptors ligands |
-
1957
- 1957-10-28 GB GB33521/57A patent/GB872300A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3166571A (en) * | 1962-06-06 | 1965-01-19 | American Cyanamid Co | 1-phenyl-1, 2-cyclopropane dicarboximides |
| EP1140828B1 (en) * | 1998-12-23 | 2006-08-09 | Pfizer Limited | 3-azabicyclo¬3.1.0|hexane derivatives as opiate receptors ligands |
| AP1852A (en) * | 1998-12-23 | 2008-05-29 | Pfizer | '3-Azabicyclo{3.1.0] hexane derivatives as opiate receptors ligands. |
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