GB2234896B - Processes for the preparation of sustained release formulations of water soluble peptides - Google Patents

Processes for the preparation of sustained release formulations of water soluble peptides

Info

Publication number: GB2234896B
Authority: GB; United Kingdom
Prior art keywords: processes; preparation; water soluble; sustained release; release formulations
Prior art date: 1989-07-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

GB9014704A

Other versions

GB2234896A (en

GB9014704D0 (en

Inventor

David Bodmer

Jones Wing Fong

Thomas Kissel

Hawkins Valliant Maulding

Oskar Nagele

Jane Edna Pearson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-07

Filing date

1990-07-03

Publication date

1994-01-19

1990-07-03 Application filed by Sandoz AG filed Critical Sandoz AG

1990-08-22 Publication of GB9014704D0 publication Critical patent/GB9014704D0/en

1991-02-20 Publication of GB2234896A publication Critical patent/GB2234896A/en

1994-01-19 Application granted granted Critical

1994-01-19 Publication of GB2234896B publication Critical patent/GB2234896B/en

2010-07-03 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cosmetics (AREA)

GB9014704A 1989-07-07 1990-07-03 Processes for the preparation of sustained release formulations of water soluble peptides Expired - Lifetime GB2234896B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US37702389A	1989-07-07	1989-07-07
US41134789A	1989-09-22	1989-09-22

Publications (3)

Publication Number	Publication Date
GB9014704D0 GB9014704D0 (en)	1990-08-22
GB2234896A GB2234896A (en)	1991-02-20
GB2234896B true GB2234896B (en)	1994-01-19

Family

ID=27007654

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GB9014704A Expired - Lifetime GB2234896B (en)	1989-07-07	1990-07-03	Processes for the preparation of sustained release formulations of water soluble peptides
GB9306204A Expired - Lifetime GB2265311B (en)	1989-07-07	1993-03-25	Sustained release formulations of water soluble peptides

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
GB9306204A Expired - Lifetime GB2265311B (en)	1989-07-07	1993-03-25	Sustained release formulations of water soluble peptides

Country Status (27)

Country	Link
JP (5)	JPH0832624B2 (en)
KR (2)	KR100303681B1 (en)
AT (1)	AT406225B (en)
AU (2)	AU641407B2 (en)
BE (1)	BE1004486A3 (en)
CA (1)	CA2020477C (en)
CH (1)	CH685230A5 (en)
CY (1)	CY1965A (en)
DE (2)	DE4021517B4 (en)
DK (1)	DK175849B1 (en)
FI (3)	FI108611B (en)
FR (1)	FR2649319A1 (en)
GB (2)	GB2234896B (en)
GR (1)	GR1001121B (en)
HK (2)	HK97695A (en)
HU (2)	HU221294B1 (en)
IE (2)	IE64411B1 (en)
IL (3)	IL94983A (en)
IT (1)	IT1241460B (en)
LU (1)	LU87764A1 (en)
MY (1)	MY106722A (en)
NL (1)	NL195027C (en)
NO (2)	NO302928B1 (en)
NZ (1)	NZ234384A (en)
PT (1)	PT94628B (en)
SE (1)	SE512992C2 (en)
SG (1)	SG26416G (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6743444B2 (en)	1995-11-09	2004-06-01	Microbiological Research Authority	Method of making microencapsulated DNA for vaccination and gene therapy

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4990336A (en) *	1989-02-08	1991-02-05	Biosearch, Inc.	Sustained release dosage form
YU48420B (en) *	1991-03-25	1998-07-10	Hoechst Aktiengesellschaft	PROCEDURE FOR OBTAINING BIOLOGICAL DEGRADABLE MICROPARTICLES WITH LONG TERM ACTION
CH683149A5 (en) *	1991-07-22	1994-01-31	Debio Rech Pharma Sa	Process for the preparation of microspheres of a biodegradable polymeric material.
US6013853A (en) *	1992-02-14	2000-01-11	The University Of Texas System	Continuous release polymeric implant carrier
US5876452A (en) *	1992-02-14	1999-03-02	Board Of Regents, University Of Texas System	Biodegradable implant
DE4218510A1 (en) *	1992-06-02	1993-12-09	Pharmatech Gmbh	Process for the preparation of biodegradable polyesters
AU4198793A (en) †	1992-07-24	1994-01-27	Takeda Chemical Industries Ltd.	Microparticle preparation and production thereof
CA2123144A1 (en) *	1993-05-10	1994-11-11	David Bodmer	Stabilisation of pharmacologically active compounds in sustained release compositions
GB9310781D0 (en) *	1993-05-25	1993-07-14	Davis Stanley S	Preparation of microparticles
US5603960A (en) *	1993-05-25	1997-02-18	O'hagan; Derek T.	Preparation of microparticles and method of immunization
CN1074923C (en)	1993-11-19	2001-11-21	詹森药业有限公司	Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
AU717113B2 (en)	1995-11-09	2000-03-16	Health Protection Agency	Microencapsulated DNA for vaccination and gene therapy
DE19545257A1 (en)	1995-11-24	1997-06-19	Schering Ag	Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
US5817343A (en) *	1996-05-14	1998-10-06	Alkermes, Inc.	Method for fabricating polymer-based controlled-release devices
US5968895A (en) *	1996-12-11	1999-10-19	Praecis Pharmaceuticals, Inc.	Pharmaceutical formulations for sustained drug delivery
US6126919A (en) *	1997-02-07	2000-10-03	3M Innovative Properties Company	Biocompatible compounds for pharmaceutical drug delivery systems
GB9810236D0 (en)	1998-05-13	1998-07-08	Microbiological Res Authority	Improvements relating to encapsulation of bioactive agents
US6632457B1 (en) *	1998-08-14	2003-10-14	Incept Llc	Composite hydrogel drug delivery systems
US7107268B1 (en)	1998-11-12	2006-09-12	Printable Technologies, Inc.	Centralized system and method for managing enterprise operations
US6226656B1 (en)	1998-11-12	2001-05-01	Sourcefinder, Inc.	System and method for creating, generating and processing user-defined generic specs
US6204308B1 (en)	1999-03-01	2001-03-20	Novartis Ag	Organic compounds
EP1044683A1 (en)	1999-04-15	2000-10-18	Debio Recherche Pharmaceutique S.A.	One-step dispersion method for the microencapsulation of water soluble substances
US6461631B1 (en) *	1999-11-16	2002-10-08	Atrix Laboratories, Inc.	Biodegradable polymer composition
KR100392501B1 (en) *	2000-06-28	2003-07-22	동국제약 주식회사	Preparation Method for Sustained Release Microparticles by Multiple Emulsion Method and Micropartic les Thereof
US6824822B2 (en) *	2001-08-31	2004-11-30	Alkermes Controlled Therapeutics Inc. Ii	Residual solvent extraction method and microparticles produced thereby
US6899898B2 (en)	2000-12-21	2005-05-31	Nektar Therapeutics	Induced phase transition method for the production of microparticles containing hydrophobic active agents
US20040097419A1 (en) *	2002-11-19	2004-05-20	Holger Petersen	Organic compounds
AR044852A1 (en) *	2003-06-24	2005-10-05	Novartis Ag	A PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION THAT INCLUDES A SOMATOSTATINE ANALOG
JP2008518881A (en) *	2003-07-18	2008-06-05	オークウッドラボラトリーズ，エル．エル．シー．	Prevention of molecular weight reduction, impurity formation and gelation of polymer in polymer composition
MY158342A (en)	2003-11-14	2016-09-30	Novartis Ag	Pharmaceutical composition
JPWO2005082405A1 (en) *	2004-02-26	2007-10-25	独立行政法人科学技術振興機構	Sustained release fine particle preparation for protein drug injection and its production method
DE102004053373A1 (en) *	2004-11-02	2006-05-04	Justus-Liebig-Universität Giessen	Invention relating to nano / meso-fiber anisometric particles in the form of nano / meso-fiber tubes, cables and their curved or branched modifications
KR100741867B1 (en) *	2005-07-05	2007-07-24	전북대학교산학협력단	Method of Preparation of Double Layered Microspheres Using Oil-in-water and Solvent Evaporation
IN2015DN03936A (en) *	2005-12-22	2015-10-02	Novartis Ag
KR100816065B1 (en)	2006-11-27	2008-03-24	동국제약 주식회사	Method for preparing sustained release microcapsules with excellent initial release control characteristics and microcapsules prepared by the same
CN104127367A (en)	2008-01-30	2014-11-05	诺华股份有限公司	Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers
USRE49251E1 (en)	2010-01-04	2022-10-18	Mapi Pharma Ltd.	Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
EP2621473A2 (en) *	2010-09-30	2013-08-07	Evonik Corporation	Method for removing residual organic solvent from microparticles
RU2013119810A (en) *	2010-09-30	2014-11-10	Эвоник Корпорейшн	EMULSION METHOD FOR PRODUCING MICROPARTICLES WITH LOW CONTENT OF RESIDUAL SOLVENT
TW201605488A (en)	2013-10-15	2016-02-16	大塚製藥股份有限公司	Drug for preventing and/or treating polycystic kidney disease
KR102464650B1 (en)	2016-05-03	2022-11-10	엘에스일렉트릭(주)	Current limiting device of circuit breaker
US12097292B2 (en)	2016-08-28	2024-09-24	Mapi Pharma Ltd.	Process for preparing microparticles containing glatiramer acetate
US11167003B2 (en)	2017-03-26	2021-11-09	Mapi Pharma Ltd.	Methods for suppressing or alleviating primary or secondary progressive multiple sclerosis (PPMS or SPMS) using sustained release glatiramer depot systems

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2145422A (en) *	1983-08-26	1985-03-27	Sandoz Ltd	Novel poly-esters, their preparation and pharmacological use thereof
EP0052510B1 (en) *	1980-11-18	1986-08-27	Syntex (U.S.A.) Inc.	Microencapsulation of water soluble polypeptides
US4675189A (en) *	1980-11-18	1987-06-23	Syntex (U.S.A.) Inc.	Microencapsulation of water soluble active polypeptides

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773919A (en) *	1969-10-23	1973-11-20	Du Pont	Polylactide-drug mixtures
CH649217A5 (en) *	1977-08-25	1985-05-15	Sandoz Ag	BROMOCRIPTIN CONTAINING MICROCAPSULES.
US4622244A (en) *	1979-09-04	1986-11-11	The Washington University	Process for preparation of microcapsules
US4293539A (en) *	1979-09-12	1981-10-06	Eli Lilly And Company	Controlled release formulations and method of treatment
CY1327A (en) *	1979-11-27	1986-06-27	Sandoz Ag	Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides and their use
US4389330A (en) *	1980-10-06	1983-06-21	Stolle Research And Development Corporation	Microencapsulation process
IE52535B1 (en) *	1981-02-16	1987-12-09	Ici Plc	Continuous release pharmaceutical compositions
EP0092918B1 (en) *	1982-04-22	1988-10-19	Imperial Chemical Industries Plc	Continuous release formulations
US4485101A (en) *	1983-10-11	1984-11-27	Administrators Of The Tulane Educational Fund	Peptides
JPH0657658B2 (en) *	1985-04-11	1994-08-03	住友製薬株式会社	Sustained release formulation
JPS60100516A (en) *	1983-11-04	1985-06-04	Takeda Chem Ind Ltd	Preparation of sustained release microcapsule
GB8331158D0 (en) *	1983-11-22	1983-12-29	British Telecomm	Metal/semiconductor deposition
JPS60181029A (en) *	1984-02-29	1985-09-14	Toyo Jozo Co Ltd	Preparation of sustained release preparation
CH660302A5 (en) *	1984-10-17	1987-04-15	Debiopharm Sa	HETEROGENEOUS PHASE MICRO-ENCAPSULATION PROCESS OF WATER-SOLUBLE DRUG SUBSTANCES.
ATE61935T1 (en) *	1985-02-07	1991-04-15	Takeda Chemical Industries Ltd	PROCESS FOR PRODUCTION OF MICROCAPSULES.
US4725577A (en) *	1985-04-25	1988-02-16	Administrators Of The Tulane Educational Fund	Biologically active lysine containing octapeptides
CH665558A5 (en) *	1985-10-09	1988-05-31	Debiopharm Sa	Phase sepn. prodn. of microcapsules for water soluble pharmaceuticals - using fluoro-substd. aliphatic hydrocarbon as non-solvent in the hardening stage
JP2539789B2 (en) *	1986-03-06	1996-10-02	日本原子力研究所	Process for producing sustained-release drug complex composed of polylactone
GB2193891B (en) *	1986-08-18	1990-07-25	Sandoz Ltd	Nasal pharmaceutical composition containing a somatostatin anologue.
JPH0725689B2 (en) *	1986-10-07	1995-03-22	中外製薬株式会社	Sustained-release preparation containing granulocyte colony-stimulating factor
GB2209937B (en) *	1987-09-21	1991-07-03	Depiopharm S A	Water insoluble polypeptides
CH672887A5 (en) *	1987-10-14	1990-01-15	Debiopharm Sa
DE3738228A1 (en) *	1987-11-11	1989-05-24	Hoechst Ag	METHOD FOR PRODUCING BIODEGRADABLE MICRO-CAPSULES OF WATER-SOLUBLE PEPTIDES AND PROTEINS AND MICRO-CAPSULES OBTAINED BY THIS PROCESS
JP2653255B2 (en) *	1990-02-13	1997-09-17	武田薬品工業株式会社	Long-term sustained release microcapsules

1990
- 1990-06-25 HU HU974/90A patent/HU221294B1/en unknown
- 1990-07-03 SG SG1995907374A patent/SG26416G/en unknown
- 1990-07-03 GB GB9014704A patent/GB2234896B/en not_active Expired - Lifetime
- 1990-07-05 FR FR9008718A patent/FR2649319A1/en active Granted
- 1990-07-05 IL IL9498390A patent/IL94983A/en active IP Right Grant
- 1990-07-05 GR GR900100513A patent/GR1001121B/en not_active IP Right Cessation
- 1990-07-05 CH CH2249/90A patent/CH685230A5/en not_active IP Right Cessation
- 1990-07-05 AU AU58746/90A patent/AU641407B2/en not_active Expired
- 1990-07-05 DK DK199001625A patent/DK175849B1/en not_active IP Right Cessation
- 1990-07-05 IL IL13188090A patent/IL131880A/en active IP Right Grant
- 1990-07-05 IE IE43894A patent/IE64411B1/en not_active IP Right Cessation
- 1990-07-05 NZ NZ234384A patent/NZ234384A/en unknown
- 1990-07-05 NO NO903001A patent/NO302928B1/en not_active IP Right Cessation
- 1990-07-05 CA CA002020477A patent/CA2020477C/en not_active Expired - Lifetime
- 1990-07-05 NL NL9001537A patent/NL195027C/en not_active IP Right Cessation
- 1990-07-05 IT IT48113A patent/IT1241460B/en active IP Right Grant
- 1990-07-05 IL IL13188190A patent/IL131881A/en active IP Right Grant
- 1990-07-05 SE SE9002364A patent/SE512992C2/en not_active IP Right Cessation
- 1990-07-05 IE IE243590A patent/IE64216B1/en not_active IP Right Cessation
- 1990-07-05 BE BE9000693A patent/BE1004486A3/en not_active IP Right Cessation
- 1990-07-06 FI FI903429A patent/FI108611B/en active IP Right Grant
- 1990-07-06 PT PT94628A patent/PT94628B/en not_active IP Right Cessation
- 1990-07-06 AT AT0144090A patent/AT406225B/en not_active IP Right Cessation
- 1990-07-06 MY MYPI90001133A patent/MY106722A/en unknown
- 1990-07-06 JP JP2177665A patent/JPH0832624B2/en not_active Expired - Lifetime
- 1990-07-06 DE DE4021517A patent/DE4021517B4/en not_active Expired - Lifetime
- 1990-07-06 KR KR1019900010224A patent/KR100303681B1/en not_active Expired - Lifetime
- 1990-07-06 DE DE4042752A patent/DE4042752B4/en not_active Expired - Lifetime
- 1990-07-09 LU LU87764A patent/LU87764A1/en unknown
1993
- 1993-03-25 GB GB9306204A patent/GB2265311B/en not_active Expired - Lifetime
1995
- 1995-04-18 JP JP7116539A patent/JPH07309897A/en active Pending
- 1995-04-18 JP JP7116486A patent/JP2931773B2/en not_active Expired - Lifetime
- 1995-06-15 HK HK97695A patent/HK97695A/en not_active IP Right Cessation
- 1995-06-28 HU HU95P/P00523P patent/HU211602A9/en unknown
- 1995-06-29 AU AU23321/95A patent/AU687553B2/en not_active Expired
- 1995-08-15 JP JP7228646A patent/JPH08198771A/en active Pending
1996
- 1996-10-31 HK HK197496A patent/HK197496A/en not_active IP Right Cessation
1997
- 1997-07-04 CY CY196597A patent/CY1965A/en unknown
1998
- 1998-08-26 NO NO19983923A patent/NO320444B1/en unknown
1999
- 1999-09-14 KR KR1019990039209A patent/KR100442931B1/en not_active Expired - Lifetime
2000
- 2000-01-12 FI FI20000059A patent/FI109543B/en active
- 2000-01-12 FI FI20000060A patent/FI109334B/en active
2001
- 2001-01-15 JP JP2001006486A patent/JP2001233897A/en active Pending

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0052510B1 (en) *	1980-11-18	1986-08-27	Syntex (U.S.A.) Inc.	Microencapsulation of water soluble polypeptides
US4675189A (en) *	1980-11-18	1987-06-23	Syntex (U.S.A.) Inc.	Microencapsulation of water soluble active polypeptides
GB2145422A (en) *	1983-08-26	1985-03-27	Sandoz Ltd	Novel poly-esters, their preparation and pharmacological use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Controlled Release 1987, 6, 167-176 *
J. Controlled Release 1987, 6, 189-204 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6743444B2 (en)	1995-11-09	2004-06-01	Microbiological Research Authority	Method of making microencapsulated DNA for vaccination and gene therapy

Also Published As

Publication number	Publication date
IT1241460B (en)	1994-01-17
GR900100513A (en)	1991-12-10
AU687553B2 (en)	1998-02-26
MY106722A (en)	1995-07-31
IL131881A (en)	2001-12-23
NL195027C (en)	2003-12-02
AU641407B2 (en)	1993-09-23
JPH07309897A (en)	1995-11-28
LU87764A1 (en)	1992-03-11
HK197496A (en)	1996-11-08
NL195027B (en)	2003-08-01
JP2001233897A (en)	2001-08-28
FI20000059L (en)	2000-01-12
AU5874690A (en)	1991-01-10
HU221294B1 (en)	2002-09-28
IT9048113A0 (en)	1990-07-05
SE9002364D0 (en)	1990-07-05
GB2234896A (en)	1991-02-20
AU2332195A (en)	1995-09-07
AT406225B (en)	2000-03-27
KR100303681B1 (en)	2002-05-16
FI903429A0 (en)	1990-07-06
NO903001L (en)	1991-01-08
IT9048113A1 (en)	1992-01-05
JP2931773B2 (en)	1999-08-09
GB9306204D0 (en)	1993-05-19
IE902435A1 (en)	1991-02-13
DK175849B1 (en)	2005-03-29
GR1001121B (en)	1993-04-28
NO983923D0 (en)	1998-08-26
DE4021517A1 (en)	1991-01-17
DK162590A (en)	1991-01-08
NO320444B1 (en)	2005-12-05
FR2649319B1 (en)	1994-12-09
CA2020477C (en)	2000-11-21
FR2649319A1 (en)	1991-01-11
HU903974D0 (en)	1990-11-28
DE4021517B4 (en)	2009-04-09
DE4042752B4 (en)	2009-05-07
FI108611B (en)	2002-02-28
NO302928B1 (en)	1998-05-11
HU211602A9 (en)	1995-12-28
SG26416G (en)	1995-09-01
PT94628B (en)	1997-06-30
HUT54037A (en)	1991-01-28
NZ234384A (en)	1994-05-26
PT94628A (en)	1991-03-20
GB2265311A (en)	1993-09-29
KR910002430A (en)	1991-02-25
IL94983A (en)	1999-08-17
SE9002364L (en)	1991-01-08
FI109543B (en)	2002-08-30
HK97695A (en)	1995-06-23
GB9014704D0 (en)	1990-08-22
NO983923L (en)	1991-01-08
JPH0832624B2 (en)	1996-03-29
NL9001537A (en)	1991-02-01
SE512992C2 (en)	2000-06-12
IL131880A (en)	2001-12-23
FI20000060L (en)	2000-01-12
BE1004486A3 (en)	1992-12-01
NO903001D0 (en)	1990-07-05
DK162590D0 (en)	1990-07-05
GB2265311B (en)	1994-02-09
CY1965A (en)	1997-07-04
ATA144090A (en)	1999-08-15
IE64411B1 (en)	1995-08-09
IE64216B1 (en)	1995-07-26
IL94983A0 (en)	1991-06-10
KR100442931B1 (en)	2004-08-02
CH685230A5 (en)	1995-05-15
JPH0368511A (en)	1991-03-25
CA2020477A1 (en)	1991-01-08
FI109334B (en)	2002-07-15
JPH08198771A (en)	1996-08-06
JPH07285853A (en)	1995-10-31

Publication	Publication Date	Title
GB2234896B (en)	1994-01-19	Processes for the preparation of sustained release formulations of water soluble peptides
PH30995A (en)	1997-12-23	Sustained release formulations of water soluble peptides.
GB2230185B (en)	1993-05-12	Sustained release pharmaceutical compositions
IL87790A (en)	1992-05-25	Sustained release compositions containing water insoluble polypeptides
AU622526B2 (en)	1992-04-09	Sustained release pharmaceutical preparation
ZA915565B (en)	1992-04-29	Preparation process of sustained release compositions and the compositions thus obtained
AU6893287A (en)	1987-08-14	Sustained release pharmaceutical preparation
EP0230654A3 (en)	1989-02-01	Sustained pulsewise release pharmaceutical preparation
IL89702A0 (en)	1989-09-28	Water soluble ibuprofen compositions,processes for the preparation thereof and pharmaceutical compositions containing the same
GB9024342D0 (en)	1990-12-19	Process for the preparation of branched olefins
IL95663A0 (en)	1991-06-30	Stabilized aqueous formulations of small peptides
IL98508A0 (en)	1992-07-15	Water insoluble microencapsular pharmaceutical compositions and methods for the preparation thereof
ZA902635B (en)	1990-12-28	Process for the preparation of cefodizime sodium
EP0419412A3 (en)	1991-05-15	Process for the preparation of benzotriazoles
ZA904925B (en)	1992-02-26	Sustained release pharmaceutical compositions
GB2195893B (en)	1991-05-08	Sustained release pharmaceutical compositions
EP0416406A3 (en)	1992-05-27	Process for the preparation of alkylhalosilanes
HU906211D0 (en)	1991-03-28	Process for the preparation of anthelminthics
ZA905327B (en)	1992-03-25	Sustained release formulations of water soluble peptides
IL131881A0 (en)	2001-03-19	Sustained release formulation comprising octreotide
GB8922061D0 (en)	1989-11-15	Controlled release formulations
HU895935D0 (en)	1990-02-28	Process for the preparation of water-soluble iode complex
IE890932L (en)	1989-09-25	Water soluble ibuprofen compositions
CA63032S (en)	1989-04-25	Bag for the preparation of ice-lollies
IE861214L (en)	1986-11-09	Compositions for the preparation of micro-particles for¹prolonged release

Legal Events

Date	Code	Title	Description
1997-06-25	732E	Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
2010-07-28	PE20	Patent expired after termination of 20 years	Expiry date: 20100702

GB2234896B - Processes for the preparation of sustained release formulations of water soluble peptides - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (3)

Family

ID=27007654

Family Applications (2)

Family Applications After (1)

Country Status (27)

Cited By (1)

Families Citing this family (43)

Citations (3)

Family Cites Families (24)

Patent Citations (3)

Non-Patent Citations (2)

Cited By (1)

Also Published As

Similar Documents

Legal Events