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GB1503581A - Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds - Google Patents

Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds

Info

Publication number
GB1503581A
GB1503581A GB7625/75A GB762575A GB1503581A GB 1503581 A GB1503581 A GB 1503581A GB 7625/75 A GB7625/75 A GB 7625/75A GB 762575 A GB762575 A GB 762575A GB 1503581 A GB1503581 A GB 1503581A
Authority
GB
United Kingdom
Prior art keywords
cephem
beta
amino
manufacture
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7625/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH269374A external-priority patent/CH601310A5/en
Priority claimed from CH776674A external-priority patent/CH610584A5/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Priority to GB27583/77A priority Critical patent/GB1503639A/en
Priority to GB27584/77A priority patent/GB1503640A/en
Priority to GB27582/77A priority patent/GB1503638A/en
Publication of GB1503581A publication Critical patent/GB1503581A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1503581 Preparation of ceph-2- or -3-em derivatives CIBA-GEIGY AG 24 Feb 1975 [26 Feb 1974 5 June 1974 12 Aug 1974] 7625/75 Heading C2C Compounds IA and IB (R 1 <SP>a</SP> is H or a protecting group; R 1 b is H or acyl; or R 1 <SP>a</SP> and R 1 <SP>b</SP> together form a divalent protecting group; R 2 is OH or a group which with the adjacent -CO- group forms protected carboxyl; and R 3 is H, 1-7C alkyl or a protecting group) and the 1-oxides of the ceph- 3-em compounds are prepared by cyclization of a compound II followed, where necessary, by deprotection and/or other conventional modifications.
GB7625/75A 1974-02-26 1975-02-24 Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds Expired GB1503581A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB27583/77A GB1503639A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-hydroxy-crotonic acid derivatives
GB27584/77A GB1503640A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-substitutedhydrody-crotonic and isocrotonic acid derivatives
GB27582/77A GB1503638A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-methylenebutyric acid derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH269374A CH601310A5 (en) 1974-02-26 1974-02-26 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CH776674A CH610584A5 (en) 1974-02-26 1974-06-05 Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CH1100074 1974-08-12

Publications (1)

Publication Number Publication Date
GB1503581A true GB1503581A (en) 1978-03-15

Family

ID=27173851

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7625/75A Expired GB1503581A (en) 1974-02-26 1975-02-24 Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds

Country Status (21)

Country Link
JP (1) JPS625919B2 (en)
AR (1) AR208538A1 (en)
AT (2) AT337362B (en)
AU (1) AU498131B2 (en)
BE (1) BE825919A (en)
BG (1) BG26201A3 (en)
CA (2) CA1059988A (en)
DD (1) DD117074A5 (en)
DE (1) DE2506330A1 (en)
DK (2) DK73475A (en)
ES (2) ES435110A1 (en)
FI (1) FI66389C (en)
FR (1) FR2261761B1 (en)
GB (1) GB1503581A (en)
HU (1) HU175212B (en)
IE (1) IE40695B1 (en)
IL (1) IL46699A (en)
NL (1) NL7502292A (en)
NO (1) NO750625L (en)
NZ (1) NZ176623A (en)
SE (3) SE431652B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10682369B2 (en) 2017-09-21 2020-06-16 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044247B (en) * 1974-08-02 1980-03-20 Farmaceutici Italia INTERMEDIATES FOR THE SYNTHESIS OF LACTAMIC DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
JPS5198265A (en) * 1975-02-17 1976-08-30
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
AT342197B (en) * 1975-02-20 1978-03-28 Ciba Geigy Ag NEW PROCESS FOR PRODUCING 3-CEPHEM CONNECTIONS
US4029645A (en) * 1975-11-17 1977-06-14 E. R. Squibb & Sons, Inc. Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
JPH0639474B2 (en) * 1983-03-04 1994-05-25 大塚化学株式会社 Method for producing cephalosporin compound
JPS59228854A (en) * 1983-06-08 1984-12-22 真井　康博 Chemical liquid injection by compressed gas and chemical liquid storing syringe
GB2152497B (en) * 1983-11-28 1987-08-05 Otsuka Kagaku Kk Process for the preparation of azetidinone derivatives
JPS60237061A (en) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd Preparation of azetidinone derivative
JPS60126263A (en) * 1983-12-12 1985-07-05 Otsuka Chem Co Ltd Production of azetidinone derivative
JPS60115562A (en) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd Production of azetidinone derivative
JPS61178961A (en) * 1985-02-01 1986-08-11 Otsuka Chem Co Ltd Production of azetidinone derivative
DE3725375A1 (en) * 1987-07-31 1989-02-09 Bayer Ag STABLE OXAPENEM-3-CARBONSAEURES
JP3195959B2 (en) * 1991-03-13 2001-08-06 大塚化学株式会社 Method for producing 3-hydroxycephem derivative
KR20050087791A (en) * 2002-11-01 2005-08-31 오키드 케미칼즈 앤드 파마수티컬즈 리미티드 An improved process for the preparation of chloro methyl cephem derivatives
IN2014CN04530A (en) 2011-12-20 2015-09-11 Hoffmann La Roche
CN104011061B (en) 2011-12-20 2017-06-13 里博科学有限责任公司 As HCV rna replicon inhibitor 2 ', ' the methyl substituted nucleoside derivates of 4 ' difluoro 2
CA2912682C (en) 2013-05-16 2021-07-06 Riboscience Llc 4'-fluoro-2'-methyl substituted nucleoside derivatives
KR20160039154A (en) 2013-05-16 2016-04-08 리보사이언스 엘엘씨 4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230372A1 (en) * 1972-06-21 1973-01-11 Fujisawa Pharmaceutical Co Cepham and cephem derivs - useful as antibiotics
SE428022B (en) * 1972-06-29 1983-05-30 Ciba Geigy Ag 7BETA-AMINO-CEFAM-3-ON-4-CARBOXYLIC ACID COMPOUNDS FOR USE FOR THE PRODUCTION OF CEPHALOSPORINE DERIVATIVES
AR206201A1 (en) * 1972-06-29 1976-07-07 Ciba Geigy Ag PROCEDURE FOR OBTAINING ACID COMPOUNDS 7BETA-AMINO-3-CEFEM-3-01-4-CARBOXILICO0-SUBSTITUIDOS

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10682369B2 (en) 2017-09-21 2020-06-16 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
US11351186B2 (en) 2017-09-21 2022-06-07 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

Also Published As

Publication number Publication date
CA1059988A (en) 1979-08-07
SE7807810L (en) 1978-07-13
AT350068B (en) 1979-05-10
IL46699A (en) 1977-11-30
DD117074A5 (en) 1975-12-20
BE825919A (en) 1975-08-25
NO750625L (en) 1975-08-27
NZ176623A (en) 1978-04-03
CA1080713A (en) 1980-07-01
ES435110A1 (en) 1977-03-16
HU175212B (en) 1980-06-28
ATA28178A (en) 1978-10-15
FI66389C (en) 1984-10-10
BG26201A3 (en) 1979-02-15
IL46699A0 (en) 1975-04-25
SE438855B (en) 1985-05-13
FR2261761A1 (en) 1975-09-19
JPS625919B2 (en) 1987-02-07
FI66389B (en) 1984-06-29
AU7849875A (en) 1976-08-26
DK73475A (en) 1975-10-20
AT337362B (en) 1977-06-27
DK348678A (en) 1978-08-07
AR208538A1 (en) 1977-02-15
SE438854B (en) 1985-05-13
IE40695B1 (en) 1979-08-01
SE431652B (en) 1984-02-20
ES452915A1 (en) 1977-11-01
SE7807811L (en) 1978-07-13
FR2261761B1 (en) 1978-08-18
AU498131B2 (en) 1979-02-15
SE7501317L (en) 1975-08-27
NL7502292A (en) 1975-08-28
FI750503A (en) 1975-08-27
DE2506330A1 (en) 1975-09-04
JPS50129590A (en) 1975-10-13
IE40695L (en) 1975-08-26
ATA108275A (en) 1976-10-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee