ES452915A1 - Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds - Google Patents
Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compoundsInfo
- Publication number
- ES452915A1 ES452915A1 ES452915A ES452915A ES452915A1 ES 452915 A1 ES452915 A1 ES 452915A1 ES 452915 A ES452915 A ES 452915A ES 452915 A ES452915 A ES 452915A ES 452915 A1 ES452915 A1 ES 452915A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- transformed
- formula
- compound
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/02—Sulfinic acids; Derivatives thereof
- C07C313/04—Sulfinic acids; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Process for obtaining derivatives of 2- (3-amino-2-oxo-4-thio-1-azetidinyl) -3-hydrox-crotonic acid derivatives of the formula **(See formula)** where it means hydrogen or a protecting amino group RA1, means hydrogen or an acyl group Ac, or RA1 and together represent a bivalent protecting amino group and RA2 means, hydroxy or, together with the carbonyl group -C (= 0) -, a group protector of carboxyl function, Ro3 means lower chyl or a protective hydroxy group and Y means an exit group, as well as its salts, characterized in that in a compound of formula **(See formula)** where Ra1, Rb1, RA2 and Y have the meaning indicated above, the enolic group is transformed by etherization into a -OR03 group and, if desired, into a compound obtained of formula II, where Y signifies the group -S-R4, where R4 signifies an aromatic heterocyclic moiety, optionally substituted, with up to 15.9 carbon atoms, and at least one ring nitrogen atom and optionally one further ring hetero atom, whose moiety is linked to one of its ring carbon atoms, which is linked to the ring nitrogen atom by a double bond, with the thio group -S-, the group -S-R4 is transformed into a group - SO2-R5 or -S-SO2-R5, where R5 means an aliphatic, cycloaliphatic, araliphatic or aromatic hydrocarbon residue, optionally substituted with up to 18 carbon atoms, and/or, if desired, within the definition of the final products, a compound obtained is transformed into another compound, and/or, if desired, a compound obtained with a salt-forming group is transformed into a salt or a salt obtained in the free compound or in another salt and/or if you want a mixture of isomers obtained is separated into the different isomers. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH269374A CH601310A5 (en) | 1974-02-26 | 1974-02-26 | 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn |
CH776674A CH610584A5 (en) | 1974-02-26 | 1974-06-05 | Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives |
CH1100074 | 1974-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES452915A1 true ES452915A1 (en) | 1977-11-01 |
Family
ID=27173851
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES435110A Expired ES435110A1 (en) | 1974-02-26 | 1975-02-26 | Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds |
ES452915A Expired ES452915A1 (en) | 1974-02-26 | 1976-11-02 | Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES435110A Expired ES435110A1 (en) | 1974-02-26 | 1975-02-26 | Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPS625919B2 (en) |
AR (1) | AR208538A1 (en) |
AT (2) | AT337362B (en) |
AU (1) | AU498131B2 (en) |
BE (1) | BE825919A (en) |
BG (1) | BG26201A3 (en) |
CA (2) | CA1059988A (en) |
DD (1) | DD117074A5 (en) |
DE (1) | DE2506330A1 (en) |
DK (2) | DK73475A (en) |
ES (2) | ES435110A1 (en) |
FI (1) | FI66389C (en) |
FR (1) | FR2261761B1 (en) |
GB (1) | GB1503581A (en) |
HU (1) | HU175212B (en) |
IE (1) | IE40695B1 (en) |
IL (1) | IL46699A (en) |
NL (1) | NL7502292A (en) |
NO (1) | NO750625L (en) |
NZ (1) | NZ176623A (en) |
SE (3) | SE431652B (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1044247B (en) * | 1974-08-02 | 1980-03-20 | Farmaceutici Italia | INTERMEDIATES FOR THE SYNTHESIS OF LACTAMIC DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION |
JPS5198265A (en) * | 1975-02-17 | 1976-08-30 | ||
CA1136132A (en) * | 1975-02-17 | 1982-11-23 | Teruji Tsuji | Cyclization to form cephem ring and intermediates therefor |
AT342197B (en) * | 1975-02-20 | 1978-03-28 | Ciba Geigy Ag | NEW PROCESS FOR PRODUCING 3-CEPHEM CONNECTIONS |
US4029645A (en) * | 1975-11-17 | 1977-06-14 | E. R. Squibb & Sons, Inc. | Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins |
JPH0639474B2 (en) * | 1983-03-04 | 1994-05-25 | 大塚化学株式会社 | Method for producing cephalosporin compound |
JPS59228854A (en) * | 1983-06-08 | 1984-12-22 | 真井 康博 | Chemical liquid injection by compressed gas and chemical liquid storing syringe |
GB2152497B (en) * | 1983-11-28 | 1987-08-05 | Otsuka Kagaku Kk | Process for the preparation of azetidinone derivatives |
JPS60237061A (en) * | 1984-05-08 | 1985-11-25 | Otsuka Chem Co Ltd | Preparation of azetidinone derivative |
JPS60126263A (en) * | 1983-12-12 | 1985-07-05 | Otsuka Chem Co Ltd | Production of azetidinone derivative |
JPS60115562A (en) * | 1983-11-28 | 1985-06-22 | Otsuka Chem Co Ltd | Production of azetidinone derivative |
JPS61178961A (en) * | 1985-02-01 | 1986-08-11 | Otsuka Chem Co Ltd | Production of azetidinone derivative |
DE3725375A1 (en) * | 1987-07-31 | 1989-02-09 | Bayer Ag | STABLE OXAPENEM-3-CARBONSAEURES |
JP3195959B2 (en) * | 1991-03-13 | 2001-08-06 | 大塚化学株式会社 | Method for producing 3-hydroxycephem derivative |
KR20050087791A (en) * | 2002-11-01 | 2005-08-31 | 오키드 케미칼즈 앤드 파마수티컬즈 리미티드 | An improved process for the preparation of chloro methyl cephem derivatives |
IN2014CN04530A (en) | 2011-12-20 | 2015-09-11 | Hoffmann La Roche | |
CN104011061B (en) | 2011-12-20 | 2017-06-13 | 里博科学有限责任公司 | As HCV rna replicon inhibitor 2 ', ' the methyl substituted nucleoside derivates of 4 ' difluoro 2 |
CA2912682C (en) | 2013-05-16 | 2021-07-06 | Riboscience Llc | 4'-fluoro-2'-methyl substituted nucleoside derivatives |
KR20160039154A (en) | 2013-05-16 | 2016-04-08 | 리보사이언스 엘엘씨 | 4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives |
US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
EP3684374A4 (en) | 2017-09-21 | 2021-06-16 | Riboscience LLC | 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2230372A1 (en) * | 1972-06-21 | 1973-01-11 | Fujisawa Pharmaceutical Co | Cepham and cephem derivs - useful as antibiotics |
SE428022B (en) * | 1972-06-29 | 1983-05-30 | Ciba Geigy Ag | 7BETA-AMINO-CEFAM-3-ON-4-CARBOXYLIC ACID COMPOUNDS FOR USE FOR THE PRODUCTION OF CEPHALOSPORINE DERIVATIVES |
AR206201A1 (en) * | 1972-06-29 | 1976-07-07 | Ciba Geigy Ag | PROCEDURE FOR OBTAINING ACID COMPOUNDS 7BETA-AMINO-3-CEFEM-3-01-4-CARBOXILICO0-SUBSTITUIDOS |
-
1974
- 1974-02-24 AU AU78498/75A patent/AU498131B2/en not_active Expired
-
1975
- 1975-02-06 SE SE7501317A patent/SE431652B/en not_active IP Right Cessation
- 1975-02-12 NZ NZ176623A patent/NZ176623A/en unknown
- 1975-02-13 AT AT108275A patent/AT337362B/en not_active IP Right Cessation
- 1975-02-14 DE DE19752506330 patent/DE2506330A1/en not_active Ceased
- 1975-02-21 FI FI750503A patent/FI66389C/en not_active IP Right Cessation
- 1975-02-24 FR FR7505654A patent/FR2261761B1/fr not_active Expired
- 1975-02-24 NO NO750625A patent/NO750625L/no unknown
- 1975-02-24 BG BG029066A patent/BG26201A3/en unknown
- 1975-02-24 GB GB7625/75A patent/GB1503581A/en not_active Expired
- 1975-02-24 DD DD184382A patent/DD117074A5/xx unknown
- 1975-02-25 DK DK73475*#A patent/DK73475A/da not_active Application Discontinuation
- 1975-02-25 IL IL46699A patent/IL46699A/en unknown
- 1975-02-25 IE IE401/75A patent/IE40695B1/en unknown
- 1975-02-25 CA CA220,745A patent/CA1059988A/en not_active Expired
- 1975-02-25 BE BE153680A patent/BE825919A/en not_active IP Right Cessation
- 1975-02-25 HU HU75CI1550A patent/HU175212B/en unknown
- 1975-02-26 NL NL7502292A patent/NL7502292A/en not_active Application Discontinuation
- 1975-02-26 ES ES435110A patent/ES435110A1/en not_active Expired
- 1975-02-26 JP JP50023775A patent/JPS625919B2/ja not_active Expired
- 1975-02-26 AR AR257777A patent/AR208538A1/en active
-
1976
- 1976-11-02 ES ES452915A patent/ES452915A1/en not_active Expired
-
1978
- 1978-01-16 AT AT28178A patent/AT350068B/en not_active IP Right Cessation
- 1978-07-13 SE SE7807811A patent/SE438855B/en not_active IP Right Cessation
- 1978-07-13 SE SE7807810A patent/SE438854B/en not_active IP Right Cessation
- 1978-08-07 DK DK348678A patent/DK348678A/en not_active Application Discontinuation
-
1979
- 1979-04-06 CA CA325,019A patent/CA1080713A/en not_active Expired
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