GB1544642A - 9,11-epoxy steroids and synthesis of corticosteroids therefrom - Google Patents

9,11-epoxy steroids and synthesis of corticosteroids therefrom

Info

Publication number: GB1544642A
Authority: GB; United Kingdom
Prior art keywords: corticosteroids; therefrom; synthesis; epoxy steroids; steroids
Prior art date: 1976-06-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB23169/76A

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Co

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-06-04

Filing date

1976-06-04

Publication date

1979-04-25

1976-06-04 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1976-06-04 Priority to GB23169/76A priority Critical patent/GB1544642A/en

1977-05-16 Priority to CA278,482A priority patent/CA1086715A/en

1977-05-31 Priority to JP6287977A priority patent/JPS52148062A/en

1979-04-25 Publication of GB1544642A publication Critical patent/GB1544642A/en

1986-10-08 Priority to JP61238159A priority patent/JPS62142197A/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Rheumatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

GB23169/76A 1976-06-04 1976-06-04 9,11-epoxy steroids and synthesis of corticosteroids therefrom Expired GB1544642A (en)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
GB23169/76A GB1544642A (en)	1976-06-04	1976-06-04	9,11-epoxy steroids and synthesis of corticosteroids therefrom
CA278,482A CA1086715A (en)	1976-06-04	1977-05-16	Steroids
JP6287977A JPS52148062A (en)	1976-06-04	1977-05-31	Steroids
JP61238159A JPS62142197A (en)	1976-06-04	1986-10-08	Steroids

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB23169/76A GB1544642A (en)	1976-06-04	1976-06-04	9,11-epoxy steroids and synthesis of corticosteroids therefrom

Publications (1)

Publication Number	Publication Date
GB1544642A true GB1544642A (en)	1979-04-25

Family

ID=10191289

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB23169/76A Expired GB1544642A (en)	1976-06-04	1976-06-04	9,11-epoxy steroids and synthesis of corticosteroids therefrom

Country Status (3)

Country	Link
JP (2)	JPS52148062A (en)
CA (1)	CA1086715A (en)
GB (1)	GB1544642A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3227312A1 (en) *	1982-07-19	1984-01-19	Schering AG, 1000 Berlin und 4709 Bergkamen	NEW 6.16 DIMETHYL CORTICOIDS, THEIR PRODUCTION AND USE
CN111944002A (en) *	2020-07-29	2020-11-17	河南利华制药有限公司	Beclomethasone dipropionate intermediate and preparation method thereof
CN112851734A (en) *	2019-11-27	2021-05-28	重庆华邦胜凯制药有限公司	Preparation method of betamethasone dipropionate
CN113024622A (en) *	2019-12-24	2021-06-25	天津天药药业股份有限公司	Process for continuously producing steroid hydroxyl bromide
CN113562912A (en) *	2021-06-28	2021-10-29	佳尔科生物科技南通有限公司	Method for treating spironolactone intermediate production wastewater

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2444092B1 (en)	2008-05-28	2015-09-02	ReveraGen BioPharma, Inc.	Non-hormonal steroid modulators of nf-kb for treatment of disease
EP2556083A4 (en)	2010-04-05	2013-12-04	Validus Biopharma Inc	Non-hormonal steroid modulators of nf- kappa b for treatment of disease
US10799514B2 (en)	2015-06-29	2020-10-13	Reveragen Biopharma, Inc.	Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en)	2019-03-07	2022-07-12	Reveragen Biopharma, Inc.	Aqueous oral pharmaceutical suspension compositions

1976
- 1976-06-04 GB GB23169/76A patent/GB1544642A/en not_active Expired
1977
- 1977-05-16 CA CA278,482A patent/CA1086715A/en not_active Expired
- 1977-05-31 JP JP6287977A patent/JPS52148062A/en active Granted
1986
- 1986-10-08 JP JP61238159A patent/JPS62142197A/en active Pending

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3227312A1 (en) *	1982-07-19	1984-01-19	Schering AG, 1000 Berlin und 4709 Bergkamen	NEW 6.16 DIMETHYL CORTICOIDS, THEIR PRODUCTION AND USE
EP0100874A2 (en) *	1982-07-19	1984-02-22	Schering Aktiengesellschaft	6,16-Dimethyl corticoids, their preparation and their use
EP0100874A3 (en) *	1982-07-19	1985-04-17	Schering Aktiengesellschaft Berlin Und Bergkamen	6,16-dimethyl corticoids, their preparation and their use
US4555507A (en) *	1982-07-19	1985-11-26	Schering Aktiengesellschaft	Novel 6, 16-dimethylcorticoids, their preparation and use
CN112851734A (en) *	2019-11-27	2021-05-28	重庆华邦胜凯制药有限公司	Preparation method of betamethasone dipropionate
CN112851734B (en) *	2019-11-27	2024-02-06	重庆华邦胜凯制药有限公司	Preparation method of betamethasone dipropionate
CN113024622A (en) *	2019-12-24	2021-06-25	天津天药药业股份有限公司	Process for continuously producing steroid hydroxyl bromide
CN111944002A (en) *	2020-07-29	2020-11-17	河南利华制药有限公司	Beclomethasone dipropionate intermediate and preparation method thereof
CN113562912A (en) *	2021-06-28	2021-10-29	佳尔科生物科技南通有限公司	Method for treating spironolactone intermediate production wastewater

Also Published As

Publication number	Publication date
CA1086715A (en)	1980-09-30
JPS6244560B2 (en)	1987-09-21
JPS52148062A (en)	1977-12-08
JPS62142197A (en)	1987-06-25

Publication	Publication Date	Title
GB1550568A (en)	1979-08-15	Steroid spirolactones and process for their preparation
JPS52142056A (en)	1977-11-26	Production of steroid
JPS54119024A (en)	1979-09-14	Steroid containing cream and production
AU504034B2 (en)	1979-09-27	Hydroconversion of oil-coal mixture
AU1851076A (en)	1978-04-13	15 steroids
JPS52131567A (en)	1977-11-04	Production of ttketoodelta55 steroids
GB1544642A (en)	1979-04-25	9,11-epoxy steroids and synthesis of corticosteroids therefrom
JPS54122264A (en)	1979-09-21	Steroids and manufacture
IL53692A0 (en)	1978-03-10	New steroids of the pregnane series and their preparation
IL51586A0 (en)	1977-05-31	Delta4-3-keto steroids and process for the preparation thereof
JPS5488252A (en)	1979-07-13	Manufacture of 16 alphaaalkylated steroid
ZA776014B (en)	1978-05-30	Pro-drugs for the improved delivery of certain selected anti-inflammatory steroids
JPS57106700A (en)	1982-07-02	Novel 17-oxazoline steroid derivatives, manufacture and use for manufacture of corticosteroid
JPS52100459A (en)	1977-08-23	Steroids and production thereof
GB2037290B (en)	1983-02-09	Preparation of 21-acylthio steroids of the pregn-4-ene and pregna-1,4-diene series
GB2087893B (en)	1985-02-27	New immunotherapeutic 3-amino steroids of the pregnane and 19-norpregnane series
NZ185341A (en)	1979-06-19	19-oxygenated steroids and pharmaceutical compositions
JPS5585599A (en)	1980-06-27	Steroid compound and its synthesis
JPS52142057A (en)	1977-11-26	Production of steroidal pylols
PH13879A (en)	1980-10-24	D-homo steroid and composition containing the same
JPS52136158A (en)	1977-11-14	I 125 imidazol steroid dirivatives
GB1487720A (en)	1977-10-05	Cardenolide glycosides and method of making the same
DE2861501D1 (en)	1982-02-25	Substituted estra-1,3,5(10),6-tetraenes, process for their preparation and use in the synthesis of tritium labelled steroids
IL56494A0 (en)	1979-03-12	New 11-hydroxy-steroids of the pregnane series substitutedin the 17-position and their production and use
JPS54109958A (en)	1979-08-29	Steroid compound and its manufacture

Legal Events

Date	Code	Title	Description
1979-07-11	PS	Patent sealed
1994-01-05	PCNP	Patent ceased through non-payment of renewal fee	Effective date: 19930510