GB1446093A - Antimicrobial-2-aminoalkyl-3-phenyl-indoles and compositions containing them - Google Patents
Antimicrobial-2-aminoalkyl-3-phenyl-indoles and compositions containing themInfo
- Publication number
- GB1446093A GB1446093A GB5581973A GB5581973A GB1446093A GB 1446093 A GB1446093 A GB 1446093A GB 5581973 A GB5581973 A GB 5581973A GB 5581973 A GB5581973 A GB 5581973A GB 1446093 A GB1446093 A GB 1446093A
- Authority
- GB
- United Kingdom
- Prior art keywords
- halo
- prepared
- group
- aminoalkyl
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3544—Organic compounds containing hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Indole Compounds (AREA)
Abstract
1446093 Aminoalkyl - indole derivatives SCHERICO Ltd 3 Dec 1973 [13 Dec 1972] 55819/73 Heading C2C [Also in Division A5] Novel compounds I (Alk is a 1-4C saturated, divalent, acyclic hydrocarbon group, cyclopropylidene or cyclopropylene; X is halo, NO 2 , OMe or CF 3 ; Y is H or halo, but if X is NO 2 , Y must be halo ; M is H, halo, Me or CF 3 ; and Z is H, halo, NO 2 or Me; provided Y is halo and X is at the 5-position when at least one of M and Z is H) and acid addition salts thereof are prepared by (1) reduction of a compound III (Pg is H or a protecting group and Q is a group directly reducible to -alkNH 2 ) or (2) removal of the amino blocking group or groups from a compound IV (R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> are H or a blocking group, at least one being other than H). Intermediates isolated are N-[2-(2,6-difluorobenzoyl) - 4 - chlorophenyl] - glycinonitrile prepared by reaction of 2-amino-5-chloro-2<SP>1</SP>,6<SP>1</SP>- difluorobenzophenone with KCN and paraformaldehyde and 5 - chloro - 3 - (2,6 - difluorophenyl) - indole - 2 - carbonitrile prepared by cyclization of the first named intermediate.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/473,625 US3944672A (en) | 1972-12-13 | 1974-05-28 | Method for treating microbial infections |
| US05/636,517 US3996159A (en) | 1972-12-13 | 1975-12-01 | Antimicrobial compositions |
| US05/715,598 US4070369A (en) | 1972-12-13 | 1976-08-18 | 2-Aminomethyl-5-chloro-3-(2,4-dichlorophenyl)indole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31489972A | 1972-12-13 | 1972-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1446093A true GB1446093A (en) | 1976-08-11 |
Family
ID=23221967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5581973A Expired GB1446093A (en) | 1972-12-13 | 1973-12-03 | Antimicrobial-2-aminoalkyl-3-phenyl-indoles and compositions containing them |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS4987661A (en) |
| AR (1) | AR204240A1 (en) |
| AT (1) | AT334355B (en) |
| BE (1) | BE808298A (en) |
| BR (1) | BR7309638D0 (en) |
| CA (1) | CA1026349A (en) |
| CH (1) | CH596170A5 (en) |
| DE (1) | DE2360713A1 (en) |
| DK (1) | DK139624B (en) |
| FR (1) | FR2210402B1 (en) |
| GB (1) | GB1446093A (en) |
| HU (1) | HU169937B (en) |
| IE (1) | IE38613B1 (en) |
| IL (1) | IL43763A (en) |
| IT (1) | IT1060115B (en) |
| NL (1) | NL7316822A (en) |
| PH (1) | PH13533A (en) |
| SE (2) | SE404297B (en) |
| SU (1) | SU540566A3 (en) |
| ZA (1) | ZA739342B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4070369A (en) * | 1972-12-13 | 1978-01-24 | Schering Corporation | 2-Aminomethyl-5-chloro-3-(2,4-dichlorophenyl)indole |
| US11826357B2 (en) | 2017-05-26 | 2023-11-28 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1591569A (en) * | 1967-09-22 | 1970-06-12 |
-
1973
- 1973-01-01 AR AR251389A patent/AR204240A1/en active
- 1973-12-03 GB GB5581973A patent/GB1446093A/en not_active Expired
- 1973-12-03 CH CH1699873A patent/CH596170A5/xx not_active IP Right Cessation
- 1973-12-05 IT IT83666/73A patent/IT1060115B/en active
- 1973-12-06 SE SE7316525A patent/SE404297B/en unknown
- 1973-12-06 PH PH15303A patent/PH13533A/en unknown
- 1973-12-06 IL IL43763A patent/IL43763A/en unknown
- 1973-12-06 CA CA187,551A patent/CA1026349A/en not_active Expired
- 1973-12-06 BE BE138581A patent/BE808298A/en unknown
- 1973-12-06 AT AT1020973A patent/AT334355B/en not_active IP Right Cessation
- 1973-12-06 IE IE2215/73A patent/IE38613B1/en unknown
- 1973-12-06 DE DE2360713A patent/DE2360713A1/en not_active Withdrawn
- 1973-12-06 DK DK662973AA patent/DK139624B/en unknown
- 1973-12-07 NL NL7316822A patent/NL7316822A/xx not_active Application Discontinuation
- 1973-12-07 BR BR9638/73A patent/BR7309638D0/en unknown
- 1973-12-07 ZA ZA739342A patent/ZA739342B/en unknown
- 1973-12-07 FR FR7343835A patent/FR2210402B1/fr not_active Expired
- 1973-12-07 JP JP48136242A patent/JPS4987661A/ja active Pending
- 1973-12-11 HU HUSC')455A patent/HU169937B/hu unknown
- 1973-12-12 SU SU1975424A patent/SU540566A3/en active
-
1978
- 1978-05-11 SE SE7805434A patent/SE7805434L/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4070369A (en) * | 1972-12-13 | 1978-01-24 | Schering Corporation | 2-Aminomethyl-5-chloro-3-(2,4-dichlorophenyl)indole |
| US11826357B2 (en) | 2017-05-26 | 2023-11-28 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| AT334355B (en) | 1976-01-10 |
| SU540566A3 (en) | 1976-12-25 |
| BR7309638D0 (en) | 1974-08-29 |
| DK139624C (en) | 1979-09-03 |
| DE2360713A1 (en) | 1974-07-04 |
| AR204240A1 (en) | 1975-12-10 |
| JPS4987661A (en) | 1974-08-22 |
| ATA1020973A (en) | 1976-05-15 |
| IL43763A (en) | 1979-03-12 |
| FR2210402A1 (en) | 1974-07-12 |
| AU6333373A (en) | 1975-06-12 |
| IL43763A0 (en) | 1974-03-14 |
| CA1026349A (en) | 1978-02-14 |
| ZA739342B (en) | 1974-10-30 |
| IE38613L (en) | 1974-06-13 |
| DK139624B (en) | 1979-03-19 |
| PH13533A (en) | 1980-06-19 |
| SE404297B (en) | 1978-10-02 |
| NL7316822A (en) | 1974-06-17 |
| BE808298A (en) | 1974-06-06 |
| IT1060115B (en) | 1982-07-10 |
| SE7805434L (en) | 1978-05-11 |
| FR2210402B1 (en) | 1977-01-28 |
| HU169937B (en) | 1977-02-28 |
| IE38613B1 (en) | 1978-04-26 |
| CH596170A5 (en) | 1978-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |