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GB1322069A - Aminoalkanoylaminocyclohexane derivatives - Google Patents

Aminoalkanoylaminocyclohexane derivatives

Info

Publication number
GB1322069A
GB1322069A GB3460270A GB3460270A GB1322069A GB 1322069 A GB1322069 A GB 1322069A GB 3460270 A GB3460270 A GB 3460270A GB 3460270 A GB3460270 A GB 3460270A GB 1322069 A GB1322069 A GB 1322069A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
aminoalkanoylaminocyclohexane
derivatives
benzyloxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3460270A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of GB1322069A publication Critical patent/GB1322069A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1322069 Aminoalkanoylaminocyclohexane derivatives YAMANOUCHI PHARMACEUTICAL CO Ltd 16 July 1970 [14 Aug 1969 18 Nov 1969] 34602/70 Heading C2C Novel compounds of Formula I: wherein n is 0 to 2, R 1 to R 4 are H or methyl and R 5 is H, C 1-4 alkyl, benzyl or carbonyl, are prepared either by reaction of a compound of Formula II with an acid of formula or a reactive derivative thereof, where R 6 and R 7 are H or methyl or a protecting group (in examples benzyloxycarbonyl) provided both R 6 and R 7 are not H and, if necessary, removing the benzyloxycarbonyl or other protecting group from any intermediate or (b) reacting a compound of Formula V wherein X is halogen with a compound R 3 .NH.R 4 . Intermediates of Formula V are prepared by reacting a compound of Formula II above with a compound of formula Pharmaceutical compositions in conventional forms for oral or parenteral administration and having analgesic activity comprise an above novel compound and a carrier or diluent.
GB3460270A 1969-08-14 1970-07-16 Aminoalkanoylaminocyclohexane derivatives Expired GB1322069A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6387069 1969-08-14
JP9177769 1969-11-18

Publications (1)

Publication Number Publication Date
GB1322069A true GB1322069A (en) 1973-07-04

Family

ID=26405006

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3460270A Expired GB1322069A (en) 1969-08-14 1970-07-16 Aminoalkanoylaminocyclohexane derivatives

Country Status (3)

Country Link
DE (1) DE2034625A1 (en)
FR (1) FR2068498A1 (en)
GB (1) GB1322069A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277498A (en) 1976-06-28 1981-07-07 Burroughs Wellcome Co. Amides
EP0034876A2 (en) * 1980-01-21 1981-09-02 Pfizer Inc. Branched amides of L-aspartyl-D-amino acid dipeptides and compositions thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1054961B (en) * 1976-01-23 1981-11-30 Corvi Camillo Spa PIPERAZINE DERIVATIVES SUITABLE AS ANTI-ULCER AGENTS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277498A (en) 1976-06-28 1981-07-07 Burroughs Wellcome Co. Amides
EP0034876A2 (en) * 1980-01-21 1981-09-02 Pfizer Inc. Branched amides of L-aspartyl-D-amino acid dipeptides and compositions thereof
EP0034876A3 (en) * 1980-01-21 1981-12-23 Pfizer Inc. Branched amides of l-aspartyl-d-amino acid dipeptides and compositions thereof

Also Published As

Publication number Publication date
DE2034625A1 (en) 1971-02-25
FR2068498A1 (en) 1971-08-27

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees