GB1328205A - Oxazolo-triazines - Google Patents
Oxazolo-triazinesInfo
- Publication number
- GB1328205A GB1328205A GB1328205DA GB1328205A GB 1328205 A GB1328205 A GB 1328205A GB 1328205D A GB1328205D A GB 1328205DA GB 1328205 A GB1328205 A GB 1328205A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reacting
- amino
- formula
- triazines
- oxazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1328205 Oxazolo-triazines LILLY INDUSTRIES Ltd 13 Oct 1970 [5 Nov 1969] 54286/69 Heading C2C Novel oxazolo-triazines of the Formula I in which R<SP>1</SP> and R<SP>2</SP> each are H, C 1-6 alkyl, phenyl or substituted phenyl, and when R<SP>2</SP> is H R<SP>1</SP> may additionally be CF 3 , or COX, when X is NH 2 or C 1-6 alkoxy, and R is aryl or substituted aryl are prepared by reacting oxazoles of the Formula II above in which Y is H, acyl or -CONHR with isocyanates of the formula RNCO. Alternatively compounds of Formula I above in which R 1 is CONH 2 may be made by reacting the appropriate compound in which R 1 is C 1-6 alkoxycarbonyl with ammonia. 2 - Acetamido - 4 - methyloxazole, 2 - acetamido - 4 - trifluoromethyloxazole, 2 - acetamidooxazole - 4 - carboxamide, and 2 - acetamido - 4- ethoxycarbonyloxazole are obtained by reacting the appropriate 2-amino-oxazoles with acetic anhydride. 2 - Amino - 4 - methyloxazole is made by reacting cyanamide with hydroxyacetone. 2- Amino - 4 - trifluoromethyloxazole and 2- amino - 4 - ethoxycarbonyloxazole are obtained by reacting urea with bromotrifluoracetone and ethyl bromopyruvate respectively. Pharmaceutical compounds, having antiinflammatory and diuretic activity and suitable for oral, parenteral or rectal administration, contain the above novel oxazolo-triazines and pharmaceutically acceptable carriers or diluents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5428669 | 1970-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1328205A true GB1328205A (en) | 1973-08-30 |
Family
ID=10470515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1328205D Expired GB1328205A (en) | 1970-10-13 | 1970-10-13 | Oxazolo-triazines |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1328205A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0401707A1 (en) * | 1989-06-05 | 1990-12-12 | Daiichi Pharmaceutical Co., Ltd. | Heterocyclic triazin or triazolo compounds having serotonin 2-receptor antagonistic activity |
-
1970
- 1970-10-13 GB GB1328205D patent/GB1328205A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0401707A1 (en) * | 1989-06-05 | 1990-12-12 | Daiichi Pharmaceutical Co., Ltd. | Heterocyclic triazin or triazolo compounds having serotonin 2-receptor antagonistic activity |
| US5232924A (en) * | 1989-06-05 | 1993-08-03 | Daiichi Pharmaceutical Co., Ltd. | Heterocyclic compound having serotonine 2-receptor antagonistic activity |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |