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GB1368680A - Adriamycin derivatives - Google Patents

Adriamycin derivatives

Info

Publication number
GB1368680A
GB1368680A GB5691672A GB5691672A GB1368680A GB 1368680 A GB1368680 A GB 1368680A GB 5691672 A GB5691672 A GB 5691672A GB 5691672 A GB5691672 A GB 5691672A GB 1368680 A GB1368680 A GB 1368680A
Authority
GB
United Kingdom
Prior art keywords
unsubstituted
alkyl
mono
acyl radical
radical derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5691672A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Priority to GB5691672A priority Critical patent/GB1368680A/en
Publication of GB1368680A publication Critical patent/GB1368680A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1368680 Adriamycin derivatives SOC FARMACEUTICI ITALIA 9 Dec 1972 56916/72 Headings C2A and C2C Novel compounds I in which R is an acyl radical derived from a substituted or unsubstituted, aliphatic, aromatic, cycloaliphatic, araliphatic or heterocyclic mono- or di-carboxylic acid having from 1-20 C or a therapeutically acceptable salt thereof (but not acetic acid) any substituent being halo, OH, alkyl, alkoxy, unsubstituted or mono- or di-alkylamino or NO 2 or R is an acyl radical derived from an alkyl- or aryl-carbonic or carbamic or alkylcarbamic or sulphonic acid are prepared by reaction of 14-bromodaunomycin or a salt thereof with RO-M (M is an alkali or alkaline earth metal or quaternary ammonium radical).
GB5691672A 1972-12-09 1972-12-09 Adriamycin derivatives Expired GB1368680A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB5691672A GB1368680A (en) 1972-12-09 1972-12-09 Adriamycin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5691672A GB1368680A (en) 1972-12-09 1972-12-09 Adriamycin derivatives

Publications (1)

Publication Number Publication Date
GB1368680A true GB1368680A (en) 1974-10-02

Family

ID=10477893

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5691672A Expired GB1368680A (en) 1972-12-09 1972-12-09 Adriamycin derivatives

Country Status (1)

Country Link
GB (1) GB1368680A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4299822A (en) * 1980-06-09 1981-11-10 Sidney Farber Cancer Institute, Inc. N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same
GB2169285A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Deoxydoxorubicin-14-esters
GB2169286A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Deoxy-4'-halodoxorubicin-14-esters
GB2169284A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Epidoxorubicin-14-esters
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4299822A (en) * 1980-06-09 1981-11-10 Sidney Farber Cancer Institute, Inc. N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same
GB2169285A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Deoxydoxorubicin-14-esters
GB2169286A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Deoxy-4'-halodoxorubicin-14-esters
GB2169284A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Epidoxorubicin-14-esters
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives

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Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19921208