GB1365455A - Imdazobensodiazepines - Google Patents
ImdazobensodiazepinesInfo
- Publication number
- GB1365455A GB1365455A GB4627872A GB4627872A GB1365455A GB 1365455 A GB1365455 A GB 1365455A GB 4627872 A GB4627872 A GB 4627872A GB 4627872 A GB4627872 A GB 4627872A GB 1365455 A GB1365455 A GB 1365455A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- imidazobenzodiazepines
- alkenyl
- prepared
- tranquillizers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1365455 Imidazobenzodiazepines UPJOHN CO 6 Oct 1972 [2 Nov 1971] 46278/72 Heading C2C Imidazobenzodiazepines are prepared by the following route (R = H, C 1-4 alkyl, C 3-4 alkenyl; R 1 = H, C 1-3 alkyl; R 2 = 2, 3 or 4-Py, 2-pyrimidyl, furyl, pyrryl, thienyl, C 1-3 alkyl, C 2-4 alkenyl, C 5-7 cycloalkyl or cycloalkenyl, R 3 R 4 Ph; R 3,4 = H, halogen, NO 2 , CN, CF 3 , C 1-3 alkyl, alkoxy, alkylthio; alkylsulphinyl, alkylsulphonyl or alkanoylamino, di(C 1-3 alkyl)amino; X = F, Cl, Br), optionally followed by conversion to an acid addition salt. The starting materials are prepared by heating the corresponding 1,3-dihydro-2H-1,4-benzodiazepin-2-one with phosphorus pentasulphide, and reacting the resulting 2-thione with RNH 2 . The above compounds are sedatives, hypnotics, anticonvulsants, tranquillizers and muscle relaxants, and increase growth rate, feed efficiency and milk and egg production in livestock. They may be administered in the form of pharmaceutical and veterinary preparations and feed additives containing them in association with a carrier.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19504971A | 1971-11-02 | 1971-11-02 | |
| US00364616A US3846443A (en) | 1971-11-02 | 1973-05-29 | 1H-IMIDAZO{8 1,2a{9 {8 1,4{9 BENZO-DIAZEPINE-1,2(3H)-DIONES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1365455A true GB1365455A (en) | 1974-09-04 |
Family
ID=26890656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4627872A Expired GB1365455A (en) | 1971-11-02 | 1972-10-06 | Imdazobensodiazepines |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3846443A (en) |
| JP (1) | JPS5545557B2 (en) |
| AU (1) | AU474359B2 (en) |
| BE (1) | BE790839A (en) |
| DE (1) | DE2252079A1 (en) |
| FR (1) | FR2158414B1 (en) |
| GB (1) | GB1365455A (en) |
| NL (1) | NL7214469A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA755418B (en) * | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
| US4044142A (en) * | 1975-02-03 | 1977-08-23 | Roussel Uclaf | 1,2-Dihydro-6-phenyl-1H,4H-imidazobenzodiazepin-1-ones |
| US4134976A (en) * | 1975-02-15 | 1979-01-16 | Roussel Uclaf | 1,2-Dihydro-6-phenyl-1H,4H-imidazobenzodiazepin-1-ones |
| US4185102A (en) * | 1975-11-04 | 1980-01-22 | Roussel Uclaf | 1,2-Dihydro-6-phenyl-1H,4H-imidazobenzodiazepin-1-ones |
| DE3151597A1 (en) * | 1981-12-28 | 1983-07-07 | Kali-Chemie Pharma Gmbh, 3000 Hannover | (1,2) -Anellated 1,4-BENZODIAZEPINE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| US4545935A (en) * | 1983-09-12 | 1985-10-08 | Iowa State University Research Foundation, Inc. | Amidoalkylation reactions of anilines |
| US20040209282A1 (en) * | 2002-10-30 | 2004-10-21 | Dana Ault-Riche | Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1545214A (en) * | 1966-11-23 | 1968-11-08 | Hoffmann La Roche | Process for the preparation of benzodiazepine derivatives |
| ZA713364B (en) * | 1970-06-18 | 1972-01-26 | Upjohn Co | Prganic compounds and process |
-
0
- BE BE790839D patent/BE790839A/en not_active IP Right Cessation
-
1972
- 1972-10-06 GB GB4627872A patent/GB1365455A/en not_active Expired
- 1972-10-11 AU AU47634/72A patent/AU474359B2/en not_active Expired
- 1972-10-24 DE DE2252079A patent/DE2252079A1/en active Pending
- 1972-10-26 NL NL7214469A patent/NL7214469A/xx not_active Application Discontinuation
- 1972-10-28 JP JP10764472A patent/JPS5545557B2/ja not_active Expired
- 1972-10-31 FR FR7238639A patent/FR2158414B1/fr not_active Expired
-
1973
- 1973-05-29 US US00364616A patent/US3846443A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5545557B2 (en) | 1980-11-18 |
| AU474359B2 (en) | 1976-07-22 |
| DE2252079A1 (en) | 1973-05-03 |
| JPS4856699A (en) | 1973-08-09 |
| FR2158414B1 (en) | 1977-01-14 |
| FR2158414A1 (en) | 1973-06-15 |
| NL7214469A (en) | 1973-05-04 |
| BE790839A (en) | 1973-04-30 |
| AU4763472A (en) | 1974-04-26 |
| US3846443A (en) | 1974-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |