FR2502149A1 - Nouveaux amido-aminoacides, compositions pharmaceutiques les contenant et procede de preparation de ces amido-aminoacides - Google Patents
Nouveaux amido-aminoacides, compositions pharmaceutiques les contenant et procede de preparation de ces amido-aminoacides Download PDFInfo
- Publication number
- FR2502149A1 FR2502149A1 FR8204738A FR8204738A FR2502149A1 FR 2502149 A1 FR2502149 A1 FR 2502149A1 FR 8204738 A FR8204738 A FR 8204738A FR 8204738 A FR8204738 A FR 8204738A FR 2502149 A1 FR2502149 A1 FR 2502149A1
- Authority
- FR
- France
- Prior art keywords
- group
- formula
- compound
- acid
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24540781A | 1981-03-19 | 1981-03-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2502149A1 true FR2502149A1 (fr) | 1982-09-24 |
FR2502149B1 FR2502149B1 (es) | 1985-01-18 |
Family
ID=22926526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8204738A Granted FR2502149A1 (fr) | 1981-03-19 | 1982-03-19 | Nouveaux amido-aminoacides, compositions pharmaceutiques les contenant et procede de preparation de ces amido-aminoacides |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPS57165355A (es) |
KR (1) | KR890001146B1 (es) |
AU (1) | AU558451B2 (es) |
BE (1) | BE892552A (es) |
CH (1) | CH658455A5 (es) |
DE (1) | DE3209708A1 (es) |
DK (1) | DK120982A (es) |
ES (3) | ES510498A0 (es) |
FI (1) | FI820974L (es) |
FR (1) | FR2502149A1 (es) |
GB (1) | GB2095252B (es) |
IE (1) | IE53076B1 (es) |
IL (1) | IL65247A (es) |
IN (1) | IN156096B (es) |
IT (1) | IT1150697B (es) |
NL (1) | NL8201066A (es) |
NO (1) | NO820903L (es) |
NZ (1) | NZ200047A (es) |
PH (1) | PH18657A (es) |
SE (1) | SE8201654L (es) |
ZA (1) | ZA821833B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3242599A1 (de) * | 1982-11-18 | 1984-05-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel |
US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
US4555502A (en) * | 1982-09-30 | 1985-11-26 | Merck & Co., Inc. | Aminoacyl-containing dipeptide derivatives useful as antihypertensives |
US4410807A (en) * | 1982-03-26 | 1983-10-18 | Kay Industries, Inc. | Regulating device for polyphase electrical circuits |
US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
US4520025A (en) * | 1982-07-21 | 1985-05-28 | William H. Rorer, Inc. | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
DE3302125A1 (de) * | 1983-01-22 | 1984-07-26 | Boehringer Ingelheim KG, 6507 Ingelheim | Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung |
FI841052A (fi) * | 1983-03-16 | 1984-09-17 | Usv Pharma Corp | Foereningar foer behandling av blodtryckssjukdomar. |
DE3333454A1 (de) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern |
DE3622297A1 (de) * | 1986-07-03 | 1988-01-07 | Basf Ag | Disazothiophenfarbstoffe |
US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
ES2122941B1 (es) * | 1997-05-29 | 1999-07-01 | Esteve Quimica Sa | Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato. |
DK1333026T3 (da) * | 2002-01-30 | 2007-10-22 | Servier Lab | Fremgangsmåde til fremstilling af perindopril med höj renhed og nyttige mellemforbindelser til syntesen |
ES2286325T3 (es) | 2002-12-16 | 2007-12-01 | Lupin Limited | Forma cristalina de clorhidrato de quinapril y proceso para su preparacion. |
EP1603558B1 (en) * | 2003-02-28 | 2008-05-21 | Les Laboratoires Servier S.A. | Process for preparation of perindopril and salts thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0046953A2 (de) * | 1980-08-30 | 1982-03-10 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
EP0049605A1 (en) * | 1980-10-03 | 1982-04-14 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same |
EP0049658A1 (fr) * | 1980-10-02 | 1982-04-14 | Adir | Iminodiacides substitués, leur préparation et compositions pharmaceutiques les contenant |
EP0051301A1 (de) * | 1980-11-03 | 1982-05-12 | Ciba-Geigy Ag | 1-Carboxy-azaalkanoylindolin-2-carbonsäuren, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung |
-
1982
- 1982-03-08 IN IN265/CAL/82A patent/IN156096B/en unknown
- 1982-03-15 NL NL8201066A patent/NL8201066A/nl not_active Application Discontinuation
- 1982-03-15 PH PH26998A patent/PH18657A/en unknown
- 1982-03-15 IL IL65247A patent/IL65247A/xx unknown
- 1982-03-16 SE SE8201654A patent/SE8201654L/xx not_active Application Discontinuation
- 1982-03-16 AU AU81584/82A patent/AU558451B2/en not_active Ceased
- 1982-03-17 DE DE19823209708 patent/DE3209708A1/de not_active Withdrawn
- 1982-03-17 GB GB8207770A patent/GB2095252B/en not_active Expired
- 1982-03-17 ES ES510498A patent/ES510498A0/es active Granted
- 1982-03-18 IT IT20259/82A patent/IT1150697B/it active
- 1982-03-18 DK DK120982A patent/DK120982A/da not_active Application Discontinuation
- 1982-03-18 CH CH1691/82A patent/CH658455A5/de not_active IP Right Cessation
- 1982-03-18 ZA ZA821833A patent/ZA821833B/xx unknown
- 1982-03-18 NO NO820903A patent/NO820903L/no unknown
- 1982-03-18 JP JP57041801A patent/JPS57165355A/ja active Pending
- 1982-03-18 KR KR8201157A patent/KR890001146B1/ko active
- 1982-03-18 NZ NZ200047A patent/NZ200047A/en unknown
- 1982-03-18 BE BE0/207610A patent/BE892552A/fr not_active IP Right Cessation
- 1982-03-19 FR FR8204738A patent/FR2502149A1/fr active Granted
- 1982-03-19 FI FI820974A patent/FI820974L/fi not_active Application Discontinuation
- 1982-03-19 IE IE635/82A patent/IE53076B1/en unknown
-
1983
- 1983-03-16 ES ES521030A patent/ES521030A0/es active Granted
- 1983-03-16 ES ES521031A patent/ES521031A0/es active Granted
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0046953A2 (de) * | 1980-08-30 | 1982-03-10 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
EP0049658A1 (fr) * | 1980-10-02 | 1982-04-14 | Adir | Iminodiacides substitués, leur préparation et compositions pharmaceutiques les contenant |
EP0049605A1 (en) * | 1980-10-03 | 1982-04-14 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same |
EP0051301A1 (de) * | 1980-11-03 | 1982-05-12 | Ciba-Geigy Ag | 1-Carboxy-azaalkanoylindolin-2-carbonsäuren, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung |
Also Published As
Publication number | Publication date |
---|---|
KR890001146B1 (ko) | 1989-04-25 |
IT8220259A0 (it) | 1982-03-18 |
BE892552A (fr) | 1982-09-20 |
IT1150697B (it) | 1986-12-17 |
ES8404317A1 (es) | 1984-05-16 |
IN156096B (es) | 1985-05-11 |
ES8307718A1 (es) | 1983-08-01 |
IE53076B1 (en) | 1988-06-08 |
ES8501363A1 (es) | 1984-12-01 |
GB2095252A (en) | 1982-09-29 |
IE820635L (en) | 1982-09-19 |
NZ200047A (en) | 1985-07-12 |
NO820903L (no) | 1982-09-20 |
PH18657A (en) | 1985-08-29 |
FR2502149B1 (es) | 1985-01-18 |
DE3209708A1 (de) | 1982-10-21 |
JPS57165355A (en) | 1982-10-12 |
SE8201654L (sv) | 1982-09-20 |
FI820974L (fi) | 1982-09-20 |
CH658455A5 (de) | 1986-11-14 |
ES521030A0 (es) | 1984-05-16 |
AU8158482A (en) | 1982-09-23 |
IL65247A (en) | 1987-07-31 |
KR830009065A (ko) | 1983-12-17 |
ZA821833B (en) | 1983-01-26 |
DK120982A (da) | 1982-09-20 |
IL65247A0 (en) | 1982-05-31 |
GB2095252B (en) | 1985-04-17 |
NL8201066A (nl) | 1982-10-18 |
ES521031A0 (es) | 1984-12-01 |
AU558451B2 (en) | 1987-01-29 |
ES510498A0 (es) | 1983-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0082088B1 (fr) | Nouveaux dérivés d'aminoacides, et leur application thérapeutique | |
EP0635003B1 (fr) | Derives de perhydroisoindole comme antagonistes de la substance p | |
US5414013A (en) | Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same | |
KR890003603B1 (ko) | 5-아미노-2,5-이치환된-4-하이드록시펜타노산 잔기를 함유하는 레닌 억제물의 제조방법 | |
FR2654725A1 (fr) | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. | |
EP0031741A1 (fr) | Nouveaux iminoacides substitués, leurs procédés de préparation et leur emploi comme inhibiteurs d'enzymes | |
FR2502149A1 (fr) | Nouveaux amido-aminoacides, compositions pharmaceutiques les contenant et procede de preparation de ces amido-aminoacides | |
EP0462884A1 (fr) | Dérivés de TRH, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent | |
JPH09505601A (ja) | インドリル基含有化合物類および成長ホルモン放出を促進するためのそれらの使用 | |
FR2502614A1 (fr) | Amido-aminoacides substitues sur n et leur procede de preparation | |
EP0049658A1 (fr) | Iminodiacides substitués, leur préparation et compositions pharmaceutiques les contenant | |
DK159419B (da) | Analogifremgangsmaade til fremstilling af substituerede acylderivater af octahydro-1h-indol-2-carboxylsyrer | |
KR100694528B1 (ko) | 2,5-디옥소-옥사졸리딘 중간체 화합물을 사용한, 페린도프릴 및 이의 염의 제조방법 | |
JPH0449545B2 (es) | ||
FR2622581A1 (fr) | Nouveaux derives de l-proline, leur preparation et leurs applications biologiques | |
EP0309324B1 (fr) | Procédé de synthèse d'alpha amino N alkyles et de leurs esters. Application à la synthèse de carboxyalkyl dipeptides | |
FR2605004A1 (fr) | Nouveaux derives d'amino-acides, leur procede de preparation et composition pharmaceutiques les contenant | |
US5559130A (en) | Pyrrolidinyl pyridones for treating pain | |
JPH09508628A (ja) | Hivプロテアーゼ阻害剤の製造法 | |
EP0635002B1 (fr) | Nouveaux derives de perhydroisoindole, et leur preparation | |
EP1140981B1 (fr) | Composes tripeptidiques utiles a titre d'inhibiteurs selectifs de l'aminopeptidase a et compositions pharmaceutiques correspondantes | |
FR2468589A1 (fr) | Derives aminoacyles de mercaptoacyl amino-acides, a action antihypertensive | |
JPS5980645A (ja) | 治療用ジペプチド | |
EP0061768A1 (en) | N-amido substituted dipeptides | |
EP0129461B1 (fr) | Dérivés d'acides isoindoledicarboxyliques, leur préparation et compositions pharmaceutiques les contenant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |