[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

FR2432317A1 - Nouveaux derives n-substitues de l'acide aziridinyl 2-carboxylique presentant une activite immunostimulante, leur procede de preparation et leurs applications therapeutiques - Google Patents

Nouveaux derives n-substitues de l'acide aziridinyl 2-carboxylique presentant une activite immunostimulante, leur procede de preparation et leurs applications therapeutiques

Info

Publication number
FR2432317A1
FR2432317A1 FR7919830A FR7919830A FR2432317A1 FR 2432317 A1 FR2432317 A1 FR 2432317A1 FR 7919830 A FR7919830 A FR 7919830A FR 7919830 A FR7919830 A FR 7919830A FR 2432317 A1 FR2432317 A1 FR 2432317A1
Authority
FR
France
Prior art keywords
aziridinyl
carboxylic acid
novel
preparation
therapeutic applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7919830A
Other languages
English (en)
Other versions
FR2432317B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of FR2432317A1 publication Critical patent/FR2432317A1/fr
Application granted granted Critical
Publication of FR2432317B1 publication Critical patent/FR2432317B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention est relative à des dérivés de l'acide aziridinyl 2-carboxylique substitués sur l'atome d'azote du noyau de formule :
FR7919830A 1978-08-03 1979-08-02 Nouveaux derives n-substitues de l'acide aziridinyl 2-carboxylique presentant une activite immunostimulante, leur procede de preparation et leurs applications therapeutiques Granted FR2432317A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782833986 DE2833986A1 (de) 1978-08-03 1978-08-03 Immunstimulierende n-substituierte aziridin-2-carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese substanzen enthalten

Publications (2)

Publication Number Publication Date
FR2432317A1 true FR2432317A1 (fr) 1980-02-29
FR2432317B1 FR2432317B1 (fr) 1983-03-18

Family

ID=6046078

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7919830A Granted FR2432317A1 (fr) 1978-08-03 1979-08-02 Nouveaux derives n-substitues de l'acide aziridinyl 2-carboxylique presentant une activite immunostimulante, leur procede de preparation et leurs applications therapeutiques
FR8003132A Granted FR2445316A1 (fr) 1978-08-03 1980-02-13 Nouveaux derives n-substitues de l'acide aziridinyl 2-carboxylique presentant une activite immunostimulante, leur procede de preparation et leurs applications therapeutiques

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8003132A Granted FR2445316A1 (fr) 1978-08-03 1980-02-13 Nouveaux derives n-substitues de l'acide aziridinyl 2-carboxylique presentant une activite immunostimulante, leur procede de preparation et leurs applications therapeutiques

Country Status (39)

Country Link
US (3) US4321194A (fr)
JP (2) JPS5522694A (fr)
KR (1) KR860000320B1 (fr)
AR (1) AR228945A1 (fr)
AT (1) AT379382B (fr)
AU (1) AU524572B2 (fr)
BE (1) BE878020A (fr)
CA (1) CA1142530A (fr)
CH (1) CH645540A5 (fr)
CS (1) CS227301B2 (fr)
DD (1) DD145267A5 (fr)
DE (1) DE2833986A1 (fr)
DK (1) DK156431C (fr)
EG (1) EG14369A (fr)
ES (1) ES483116A1 (fr)
FI (1) FI70570C (fr)
FR (2) FR2432317A1 (fr)
GB (2) GB2026863B (fr)
GR (1) GR74424B (fr)
HK (1) HK13285A (fr)
HU (1) HU184610B (fr)
IE (1) IE48462B1 (fr)
IL (1) IL57939A (fr)
IT (1) IT1123503B (fr)
KE (1) KE3493A (fr)
LU (1) LU81563A1 (fr)
MY (1) MY8600045A (fr)
NL (1) NL187239C (fr)
NO (1) NO152413C (fr)
NZ (1) NZ191169A (fr)
OA (1) OA06310A (fr)
PH (1) PH19007A (fr)
PL (1) PL126531B1 (fr)
PT (1) PT70009A (fr)
SE (1) SE445552B (fr)
SG (1) SG85784G (fr)
SU (1) SU1145927A3 (fr)
YU (1) YU41169B (fr)
ZA (1) ZA793966B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3446713A1 (de) * 1984-12-21 1986-06-26 Boehringer Mannheim Gmbh, 6800 Mannheim N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel
JPS6287512A (ja) * 1985-10-11 1987-04-22 ベ−リンガ−・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 選択的免疫抑制剤
US4925835A (en) * 1986-05-01 1990-05-15 Sloan-Kettering Institute For Cancer Research Aziridinyl putrescine containing compositions and their uses in treating prostate cancer
KR19980083844A (ko) * 1997-05-19 1998-12-05 이웅열 새로운 아지리딘 유도체 및 그 제조방법
FR2776292B1 (fr) * 1998-03-20 2004-09-10 Oncopharm Cephalotaxanes porteurs de chaine laterale et leur procede de synthese
KR20010000195A (ko) * 2000-08-10 2001-01-05 하현준 (2ｒ)- 및 (2ｓ)-아지리딘-2-카르복실산 에스테르 및(2ｒ)- 및 (2ｓ)-2-히드록시메틸 아지리딘 제조 방법
CA2431947A1 (fr) * 2000-11-21 2002-05-30 Gabriel Lopez-Berestein Imexon liposomique
US20030129222A1 (en) * 2000-11-21 2003-07-10 Gabriel Lopez-Berestein Liposomal imexon
US6982263B2 (en) * 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470223A1 (de) * 1962-09-05 1969-12-04 Siegfried Ag Verfahren zur Herstellung neuer stickstoffhaltiger Heterocyclen
DE2538672A1 (de) * 1975-08-30 1977-03-10 Boehringer Mannheim Gmbh Verwendung von derivaten der propionsaeure
FR2368953A1 (fr) * 1976-10-29 1978-05-26 Inst Organicheskogo Sinteza Ak Pr

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2528460A1 (de) * 1975-06-26 1977-01-13 Boehringer Mannheim Gmbh Verwendung von l-carboxamido-2- cyan-aziridin als immunstimulans
DE2530960A1 (de) 1975-07-11 1977-01-27 Huels Chemische Werke Ag 2-(n-substituierte)-aziridinyl-delta hoch 2 -oxazoline und verfahren zu ihrer herstellung
DE2656240C2 (de) * 1976-12-11 1983-11-03 Boehringer Mannheim Gmbh, 6800 Mannheim Neue Aziridin-Derivate, Verfahren zu deren Herstellung und pharmazeutische Mittel
CA1092606A (fr) * 1976-10-05 1980-12-30 Herbert Berger 1-(n-acylcarbamoyl)-2-cyano-aziridines et procede de preparation
AR218645A1 (es) * 1976-12-11 1980-06-30 Boehringer Mannheim Gmbh Procedimiento para preparar derivados de esteres del acido 1-aziridina-carboxilico

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470223A1 (de) * 1962-09-05 1969-12-04 Siegfried Ag Verfahren zur Herstellung neuer stickstoffhaltiger Heterocyclen
DE2538672A1 (de) * 1975-08-30 1977-03-10 Boehringer Mannheim Gmbh Verwendung von derivaten der propionsaeure
FR2368953A1 (fr) * 1976-10-29 1978-05-26 Inst Organicheskogo Sinteza Ak Pr

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1977 *

Also Published As

Publication number Publication date
PT70009A (de) 1979-08-01
FI70570C (fi) 1986-09-24
IT7924769A0 (it) 1979-07-30
DK156431B (da) 1989-08-21
MY8600045A (en) 1986-12-31
IE48462B1 (en) 1985-01-23
YU41169B (en) 1986-12-31
JPH0257523B2 (fr) 1990-12-05
LU81563A1 (de) 1980-08-08
NO152413C (no) 1985-09-25
JPS63258415A (ja) 1988-10-25
IE791478L (en) 1980-02-03
GB2026863A (en) 1980-02-13
NO152413B (no) 1985-06-17
HU184610B (en) 1984-09-28
OA06310A (fr) 1981-06-30
ES483116A1 (es) 1980-04-16
KE3493A (en) 1985-02-01
IL57939A0 (en) 1979-11-30
IL57939A (en) 1985-02-28
PL126531B1 (en) 1983-08-31
CA1142530A (fr) 1983-03-08
DK156431C (da) 1990-01-22
FI792393A (fi) 1980-02-04
SG85784G (en) 1985-06-07
IT1123503B (it) 1986-04-30
US4409236A (en) 1983-10-11
EG14369A (en) 1983-12-31
ATA531479A (de) 1985-05-15
DE2833986A1 (de) 1980-02-21
SU1145927A3 (ru) 1985-03-15
NO792545L (no) 1980-02-05
YU188179A (en) 1983-06-30
FR2445316B1 (fr) 1983-07-29
GR74424B (fr) 1984-06-28
KR830000902A (ko) 1983-04-28
NL187239C (nl) 1991-07-16
DK320379A (da) 1980-02-04
JPS5522694A (en) 1980-02-18
GB2106896B (en) 1983-08-17
GB2026863B (en) 1983-03-30
FR2445316A1 (fr) 1980-07-25
AR228945A1 (es) 1983-05-13
US4321194A (en) 1982-03-23
JPS6243991B2 (fr) 1987-09-17
FR2432317B1 (fr) 1983-03-18
DE2833986C2 (fr) 1988-04-07
KR860000320B1 (ko) 1986-04-09
GB2106896A (en) 1983-04-20
DD145267A5 (de) 1980-12-03
FI70570B (fi) 1986-06-06
PH19007A (en) 1985-12-03
CH645540A5 (de) 1984-10-15
HK13285A (en) 1985-03-01
ZA793966B (en) 1980-08-27
US4410532A (en) 1983-10-18
SE7906461L (sv) 1980-02-04
SE445552B (sv) 1986-06-30
PL217527A1 (fr) 1980-07-01
NL7905855A (nl) 1980-02-05
AU524572B2 (en) 1982-09-23
AU4930879A (en) 1980-02-07
BE878020A (fr) 1980-02-01
AT379382B (de) 1985-12-27
CS227301B2 (en) 1984-04-16
NZ191169A (en) 1981-01-23

Similar Documents

Publication Publication Date Title
FR2381028A1 (fr) Derives d'acide benzoique, leur procede de preparation et leur application en therapeutique
FR2378521A1 (fr) Derives du carbostyrile, utiles notamment comme stimulants des centres b- adrenorecepteurs, et leur procede de preparation
FR2364219A1 (fr) Derives de thiazolidine, leur procede de preparation et leur application en therapeutique
FR2403989A1 (fr) Nouveaux derives a-halogenomethyles d'amines utiles comme medicaments et procedes de leur preparation
FR2405246A1 (fr) Nouveaux derives de pyrrole, leur procede de preparation et leurs applications en therapeutique
FR2427337A1 (fr) Nouveaux derives acyles de la cephalosporine, leur preparation et leurs utilisations therapeutiques
FR2372817A1 (fr) Derives d'acides thiazolidinecarboxyliques et d'acides apparentes, utiles comme agents anti-hypertension
FR2368471A1 (fr) Nouveaux amides d'acides omega-amino-carboxyliques et procedes pour leur preparation
FR2445316A1 (fr) Nouveaux derives n-substitues de l'acide aziridinyl 2-carboxylique presentant une activite immunostimulante, leur procede de preparation et leurs applications therapeutiques
FR2404626A1 (fr) Nouveaux derives a-halogenomethyles de l'acide g-aminobutyrique utiles comme medicaments et procedes de leur preparation
FR2374317A1 (fr) Derives d'acide n-(benzothiazolyl-2)oxamique et procede pour leur preparation et leur utilisation comme medicament anti-allergique
FR2394522A1 (fr) Nouveaux derives d'acides (s-phenenyl tris(carbonylimino))-5,5',5''tri-benzene-carboxyliques utiles notamment comme inhibiteurs du complement, et leur procede de preparation
FR2422405A1 (fr) Nouveaux medicaments constitues de derives de l'acide p-aminobenzoique
FR2356631A1 (fr) Nouveaux derives d'amides d'acide carboxyliques n-substitues
FR2388789A1 (fr) Derives d'acide benzoique, leur procede de preparation et leur application therapeutique
FR2355849A1 (fr) Derives de l'acide 7 b-acylamidoceph-3-eme 4-carboxyliques, leur procede de preparation et application therapeutique
FR2362841A1 (fr) Derives d'acides heterocyclyl-carboxyliques acyles utiles comme medicaments et procede pour leur preparation
FR2421616A1 (fr) Nouveaux medicaments constitues de derives de l'acide o-aminobenzoique
FR2361341A1 (fr) Procede de preparation d'esters de l'acide anthranilique
FR2435466A1 (fr) Derives de l'hydroquinone et leur procede de preparation
FR2419289A1 (fr) Derives de glyoxal-2-oxime et leur procede de preparation
FR2416214A1 (fr) Derives d'acide naphtyl-1 acetique, leur procede de preparation et leur application therapeutique
FR2446282A1 (fr) Phenylthiophenylpiperidines, leur preparation et leurs applications therapeutiques
FR2354312A2 (fr) Nouveaux derives de substitution du 1,3-diphenoxypropanol-(2) ainsi que leur procede de fabrication et leur application therapeutique
FR2372835A1 (fr) Nouveaux derives d'acide polyparabanique et leur procede de preparation

Legal Events

Date Code Title Description
ST Notification of lapse