[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

FR2422643A1 - Nouveaux derives d'imidazolidine, leur preparation et leur application comme medicaments - Google Patents

Nouveaux derives d'imidazolidine, leur preparation et leur application comme medicaments

Info

Publication number
FR2422643A1
FR2422643A1 FR7830329A FR7830329A FR2422643A1 FR 2422643 A1 FR2422643 A1 FR 2422643A1 FR 7830329 A FR7830329 A FR 7830329A FR 7830329 A FR7830329 A FR 7830329A FR 2422643 A1 FR2422643 A1 FR 2422643A1
Authority
FR
France
Prior art keywords
preparation
application
imidazolidine
medicinal products
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7830329A
Other languages
English (en)
Other versions
FR2422643B1 (fr
Inventor
Karl Bernauer
Helmut Link
Harro Stohler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH546578A external-priority patent/CH642944A5/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2422643A1 publication Critical patent/FR2422643A1/fr
Application granted granted Critical
Publication of FR2422643B1 publication Critical patent/FR2422643B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nouveaux dérivés d'imidazoline, leur préparation et leur application comme médicaments. Les composés de l'invention répondent à la formule générale :
FR7830329A 1977-10-28 1978-10-25 Nouveaux derives d'imidazolidine, leur preparation et leur application comme medicaments Granted FR2422643A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
LU78407 1977-10-28
CH546578A CH642944A5 (en) 1978-05-19 1978-05-19 Urea derivatives
CH936778 1978-09-06

Publications (2)

Publication Number Publication Date
FR2422643A1 true FR2422643A1 (fr) 1979-11-09
FR2422643B1 FR2422643B1 (fr) 1982-10-29

Family

ID=27175218

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7830329A Granted FR2422643A1 (fr) 1977-10-28 1978-10-25 Nouveaux derives d'imidazolidine, leur preparation et leur application comme medicaments

Country Status (26)

Country Link
US (2) US4407814A (fr)
EP (1) EP0001813B1 (fr)
JP (1) JPS5470271A (fr)
AR (2) AR219560A1 (fr)
AT (2) AT366374B (fr)
AU (1) AU522536B2 (fr)
BR (1) BR7807097A (fr)
CA (1) CA1107744A (fr)
CU (1) CU34980A (fr)
DE (2) DE2861289D1 (fr)
DK (1) DK481678A (fr)
ES (3) ES474592A1 (fr)
FI (1) FI68618C (fr)
FR (1) FR2422643A1 (fr)
GB (1) GB2008102B (fr)
GR (1) GR70681B (fr)
IE (1) IE47962B1 (fr)
IL (1) IL55773A (fr)
IT (1) IT1099450B (fr)
MC (1) MC1220A1 (fr)
NL (1) NL7810563A (fr)
NO (1) NO151461C (fr)
NZ (1) NZ188721A (fr)
PH (1) PH13569A (fr)
PT (1) PT68705A (fr)
SE (1) SE7811194L (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI801184A (fi) * 1979-04-24 1980-10-25 Hoffmann La Roche Foerfarande foer framstaellning av imidazolidinderivat
DE2933917A1 (de) * 1979-08-22 1981-03-26 Basf Ag, 67063 Ludwigshafen 5-imino-imidazolidin-2-one und diese enthaltende herbizide.
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
DE3382406D1 (de) * 1982-04-08 1991-10-17 Shell Int Research Neue hydantoine, ihre herstellung und verwendung.
US5112983A (en) * 1987-09-28 1992-05-12 Olin Corporation Process for producing 1,2,4-triazol-5-one using organic sulfonic acids and polymers thereof as a catalyst
FR2671348B1 (fr) * 1991-01-09 1993-03-26 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
USRE35956E (en) * 1991-01-09 1998-11-10 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2715402B1 (fr) * 1994-01-05 1996-10-04 Roussel Uclaf Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
TW521073B (en) * 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2724169B1 (fr) * 1994-09-06 1997-01-03 Roussel Uclaf Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2741346B1 (fr) * 1995-11-16 1997-12-19 Roussel Uclaf Nouveau procede de preparation de derives phenylimidazolidine
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
CA2413417A1 (fr) * 2000-06-28 2002-01-03 Bristol-Myers Squibb Company Modulateurs selectifs des recepteurs androgeniques et leurs methodes d'identification, d'elaboration et d'utilisation
EP1854798A3 (fr) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Composés de succinimide hétérocyclique fondu et leurs analogies, modulateurs de la fonction de récepteur d'hormone nucléaire
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
CA2550447A1 (fr) * 2003-12-19 2005-07-07 The Regents Of The University Of California Procedes et materiaux pour evaluer des therapies du cancer de la prostate
US7718684B2 (en) * 2004-02-24 2010-05-18 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
PT2656842T (pt) 2006-03-27 2016-10-04 Univ California Modulador do recetor de androgénios para o tratamento de cancro da próstata e doenças associadas ao recetor de androgénios
EP2013187B1 (fr) 2006-03-29 2014-10-29 The Regents of The University of California Composés de diarylthiohydantoïne
AR069039A1 (es) 2007-10-26 2009-12-23 Univ California Compuestos de diarilhidantoina, composicion farmaceutica, proceso de obtencion del compuesto, utiles para desordenes hiperproliferativos
EP3357917A1 (fr) 2010-02-16 2018-08-08 Aragon Pharmaceuticals, Inc. Modulateurs de récepteur d'androgène et utilisations associées
UA124967C2 (uk) 2012-09-26 2021-12-22 Араґон Фармасьютікалз, Інк. Антиандрогени для лікування неметастатичного кастраційно-резистентного раку передміхурової залози
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
SG11202003402QA (en) 2017-10-16 2020-05-28 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE629779A (fr) *
FR1405725A (fr) * 1963-08-23 1965-07-09 Shell Int Research Procédé de préparation de la 5, 5-diméthyl-4-iminohydantoine
FR2004949A1 (fr) * 1968-03-28 1969-12-05 Geigy Ag J R
FR2024141A1 (fr) * 1968-11-25 1970-08-28 Sumitomo Chemical Co
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3134663A (en) * 1957-07-23 1964-05-26 Geigy Chem Corp Herbicidal composition and method employing hydantoins
US3690863A (en) * 1968-04-19 1972-09-12 Du Pont Esters of 3-(carboxyamino)-and 3-(thiocarboxyamino)-2-substituted crotonamides andtheir use as herbicides
JPS4916937B1 (fr) * 1970-01-21 1974-04-25
US3676456A (en) * 1970-02-27 1972-07-11 Ciba Geigy Corp Derivatives of 3-aryl-5-alkylhydantoins
JPS5136332B1 (fr) * 1970-12-09 1976-10-07
US4044021A (en) * 1971-10-21 1977-08-23 American Cyanamid Company Tetrasubstituted imidazolidine diuretics useful in the treatment of hyperaldosteronism
IL45459A (en) * 1973-09-03 1978-01-31 Ciba Geigy Ag 1-(dichlorofluoromethylthio)-3-phenyl-imidazolidine-2,4-dione derivatives their preparation and their use as bactericides and fungicides
JPS5315373A (en) * 1976-07-29 1978-02-13 Mitsubishi Chem Ind Ltd Hydantoin derivatives and fungicides containing same for agriculture and horiticulture
CA1138334A (fr) * 1977-10-28 1982-12-28 Karl Bernauer Preparations pharmaceutiques contenant certains derives de l'uree
US4358606A (en) * 1981-06-19 1982-11-09 Zoecon Corporation Esters of phenalkyloxycarbonylamino acids

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE629779A (fr) *
FR1405725A (fr) * 1963-08-23 1965-07-09 Shell Int Research Procédé de préparation de la 5, 5-diméthyl-4-iminohydantoine
FR2004949A1 (fr) * 1968-03-28 1969-12-05 Geigy Ag J R
FR2024141A1 (fr) * 1968-11-25 1970-08-28 Sumitomo Chemical Co
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/64 *

Also Published As

Publication number Publication date
PT68705A (en) 1978-11-01
DK481678A (da) 1979-04-29
DE2846946A1 (de) 1979-05-03
EP0001813A1 (fr) 1979-05-16
GB2008102B (en) 1982-07-07
FI68618C (fi) 1985-10-10
NL7810563A (nl) 1979-05-02
DE2861289D1 (en) 1982-01-14
US4482739A (en) 1984-11-13
ES480114A1 (es) 1980-04-01
NO151461C (no) 1985-04-17
ATA18281A (de) 1981-09-15
IT7829040A0 (it) 1978-10-24
AU522536B2 (en) 1982-06-10
AU4096178A (en) 1980-05-01
US4407814A (en) 1983-10-04
SE7811194L (sv) 1979-04-29
IE47962B1 (en) 1984-08-08
ES480109A1 (es) 1980-04-01
CU34980A (es) 1981-12-04
CA1107744A (fr) 1981-08-25
JPS625145B2 (fr) 1987-02-03
NO151461B (no) 1985-01-02
AT366374B (de) 1982-04-13
PH13569A (en) 1980-06-26
AT366671B (de) 1982-04-26
IL55773A0 (en) 1978-12-17
ES474592A1 (es) 1980-04-01
FI68618B (fi) 1985-06-28
IE782130L (en) 1979-04-28
JPS5470271A (en) 1979-06-05
AR220004A1 (es) 1980-09-30
NO783642L (no) 1979-05-02
AR219560A1 (es) 1980-08-29
MC1220A1 (fr) 1979-07-20
EP0001813B1 (fr) 1981-11-04
GR70681B (fr) 1982-12-20
IT1099450B (it) 1985-09-18
GB2008102A (en) 1979-05-31
FR2422643B1 (fr) 1982-10-29
BR7807097A (pt) 1979-05-08
IL55773A (en) 1982-02-28
NZ188721A (en) 1984-11-09
ATA768978A (de) 1981-08-15
FI783170A (fi) 1979-04-29

Similar Documents

Publication Publication Date Title
FR2422643A1 (fr) Nouveaux derives d'imidazolidine, leur preparation et leur application comme medicaments
FR2390420A1 (fr) Nouveaux derives cyclopeptidiques, leur preparation et leur application comme medicaments
FR2398748A1 (fr) Nouveaux derives d'imidazoquinazoline, leur preparation et leur application en tant que medicaments
FR2367053A1 (fr) Nouveaux derives de phenoxy-amino-propanol, leur preparation et leur application en tant que medicaments
FR2390428A1 (fr) Nouveaux composes polyeniques, leur preparation et leur application en tant que medicaments
FR2400512A1 (fr) Nouveaux nitro-imidazoles, leur preparation et leur application en tant que medicaments
FR2373513A1 (fr) Nouveaux derives du naphtalene, leur preparation et leur application comme medicaments
FR2387954A1 (fr) Derives de mercaptoalkylsulfonylproline et composes apparentes, et leur utilisation comme medicaments
FR2430419A1 (fr) Nouveaux derives de l'indole, leur preparation et leur application comme medicaments
FR2383165A1 (fr) Nouveaux derives d'acides phenoxy-a-phenoxy-alcanecarboxyliques, leur preparation et leur application comme herbicides
FR2398058A1 (fr) Nouveaux derives de l'indole, leur preparation et leur application comme medicaments
FR2415636A1 (fr) Nouveaux derives de la guanidine, leur preparation et leur application comme medicaments
FR2415103A1 (fr) Acides et derives d'acides 4-pyridone-3-carboxyliques, leur preparation et leur application en tant que medicaments
FR2379533A1 (fr) Tetrazolylcarbamoylquinoleines utilisables comme medicaments et leur preparation
FR2370745A1 (fr) Nouveaux derives de la morphanthridine, leur preparation et leur application comme medicaments
FR2379538A1 (fr) Nouveaux derives d'oxadiazolopyrimidine, leur preparation et leur application en tant que medicaments
FR2388799A1 (fr) Derives de pyridazinone, leur procede de preparation et leur application comme medicaments
FR2355012A1 (fr) Nouveaux derives de dihydro- et tetrahydro-iminothiazine, et leur application en tant que medicaments
FR2419928A1 (fr) Nouveaux derives de la n-phenylalanine, leur preparation et leur application comme medicaments
FR2401160A1 (fr) Nouveaux derives d'esters de vincaminol, leur preparation et leur application en tant que medicaments
FR2378015A1 (fr) Nouveaux derives de la benzo(f)isoquinoleine, leur preparation et leur application comme medicaments
FR2378781A1 (fr) Nouveaux derives d'alcaloides de l'ergot de seigle, leur preparation et leur application comme medicaments
FR2379532A1 (fr) Nouveaux derives de l'acide oxamique, leur preparation et leur application comme medicaments
FR2396748A1 (fr) Nouveaux derives de prostaglandine, leur preparation et leur application en tant que medicaments
FR2392011A1 (fr) Nouveaux derives de la 5-phenyl-1h-3-benzazepine, leur preparation et leur utilisation comme medicaments

Legal Events

Date Code Title Description
ST Notification of lapse