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FR2448899A1 - Utilisation therapeutique de l'acide 6,7-dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylique et de ses esters - Google Patents

Utilisation therapeutique de l'acide 6,7-dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylique et de ses esters

Info

Publication number
FR2448899A1
FR2448899A1 FR8009368A FR8009368A FR2448899A1 FR 2448899 A1 FR2448899 A1 FR 2448899A1 FR 8009368 A FR8009368 A FR 8009368A FR 8009368 A FR8009368 A FR 8009368A FR 2448899 A1 FR2448899 A1 FR 2448899A1
Authority
FR
France
Prior art keywords
dihydro
dichloro
oxo
esters
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8009368A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2448899A1 publication Critical patent/FR2448899A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSITION PHARMACEUTIQUE PERMETTANT DE SUPPRIMER L'INFECTION VIRALE CHEZ DES MAMMIFERES INFECTES, CARACTERISEE EN CE QU'ELLE COMPREND, COMME INGREDIENT ACTIF, UNE 3,4-DIHYDRO-3-OXOQUINOXALINE DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R ET R SONT DES ATOMES D'HYDROGENE; R ET R SONT TOUS DEUX DES ATOMES DE CHLORE; R EST UN GROUPEMENT ALKYLE EN C-C, CYCLOALKYLE EN C-C, ALCENYLE EN C-C, UN ATOME D'HYDROGENE OU UN GROUPEMENT 2-CHLOROETHYLE; ET N VAUT 0 OU 2; AINSI QUE DES EXCIPIENTS.
FR8009368A 1978-10-20 1980-04-25 Utilisation therapeutique de l'acide 6,7-dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylique et de ses esters Withdrawn FR2448899A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95315778A 1978-10-20 1978-10-20
US6044579A 1979-07-25 1979-07-25

Publications (1)

Publication Number Publication Date
FR2448899A1 true FR2448899A1 (fr) 1980-09-12

Family

ID=26739938

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7925930A Withdrawn FR2439188A1 (fr) 1978-10-20 1979-10-18 Composition pharmaceutique contenant des 3,4-dihydro-3-oxo-2-quinoxalines
FR8009368A Withdrawn FR2448899A1 (fr) 1978-10-20 1980-04-25 Utilisation therapeutique de l'acide 6,7-dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylique et de ses esters

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7925930A Withdrawn FR2439188A1 (fr) 1978-10-20 1979-10-18 Composition pharmaceutique contenant des 3,4-dihydro-3-oxo-2-quinoxalines

Country Status (19)

Country Link
US (1) US4264600A (fr)
EP (1) EP0010426A1 (fr)
JP (1) JPS5569514A (fr)
AU (1) AU5197779A (fr)
BE (1) BE879472A (fr)
CA (1) CA1145337A (fr)
DD (1) DD146705A5 (fr)
DK (1) DK444479A (fr)
ES (2) ES485221A1 (fr)
FI (1) FI793261A (fr)
FR (2) FR2439188A1 (fr)
GB (1) GB2034302A (fr)
GR (1) GR72941B (fr)
IL (1) IL58478A0 (fr)
IT (1) IT1193847B (fr)
LU (1) LU81798A1 (fr)
PH (1) PH15791A (fr)
PT (1) PT70340A (fr)
RO (1) RO78225A (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252954A (en) * 1979-10-25 1981-02-24 Eli Lilly And Company Salts of dihalo-3,4-dihydro-3-oxo-2-quinoxaline carboxylic acids and hindered amines
US4355030A (en) * 1980-11-14 1982-10-19 Eli Lilly And Company Antiviral combinations
JPH0678319B2 (ja) * 1986-03-11 1994-10-05 東ソー株式会社 キノキサリノン誘導体
US4904775A (en) * 1988-05-16 1990-02-27 E. R. Squibb & Sons, Inc. Heteroaroylhydrazide derivatives of monocyclic beta-lactam antibiotics
US5037983A (en) * 1988-05-16 1991-08-06 E. R. Squibb & Sons, Inc. 6,7-dihydroxyquinoxalines as intermediates to beta-lactam antibiotics
CA2024282A1 (fr) * 1989-09-21 1991-03-22 Peter H. Ermann Derives hydrazide heterocycliques de beta-lactam monocyclique antibiotique
US5169955A (en) * 1990-03-01 1992-12-08 Nippon Kayaku Kabushiki Kaisha Process for producing 2-hydroxyquinoxaline derivatives
ZA918014B (en) * 1990-11-05 1992-07-29 Squibb & Sons Inc Heteroaroyl derivatives of monocyclic beta-lactam antibiotics
AU9049391A (en) * 1990-12-20 1992-07-22 Warner-Lambert Company 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
US5250691A (en) * 1991-09-09 1993-10-05 E. R. Squibb & Sons, Inc. Heteroaryl derivatives of monocyclic beta-lactam antibiotics
TW274550B (fr) * 1992-09-26 1996-04-21 Hoechst Ag
US6348461B1 (en) * 1997-09-01 2002-02-19 Kyorin Pharmaceutical Co., Ltd. 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, addition salts thereof, and processes for the preparation of both
WO2012021991A1 (fr) * 2010-08-14 2012-02-23 Versitech Limited Esters de l'acide carbamimidothioïque antiviraux
EP2935215B1 (fr) * 2012-12-20 2019-11-13 Lu, Qing-Bin Composés radiosensibilisateurs destinés à être utilisés en association avec des rayonnements

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1038505A (en) * 1963-06-04 1966-08-10 Daiichi Seiyaku Co Antileprosy ointment
CH513884A (de) * 1967-10-23 1971-10-15 Donau Pharmazie Gmbh Verfahren zur Herstellung von Tetrahydro-Chinoxalin-2-onen
GB1215815A (en) 1967-12-20 1970-12-16 Research Corp Production of quinoxaline-di-n-oxides and benzimidazole mono- and di-n-oxides
GB1408675A (en) 1973-03-16 1975-10-01 Allen & Hanburys Ltd Amides derived from quinoxaline
US3654275A (en) * 1969-10-15 1972-04-04 Pfizer & Co C Quinoxalinecarboxamide antiinflammatory agents
GB1308370A (en) 1969-12-09 1973-02-21 Research Corp 1-hydroxy-3-oxo-benzimidazoles quinoxaline-di-n-oxides and benzimidazole-mono-and di-n-oxides
US3962440A (en) * 1973-12-26 1976-06-08 Eli Lilly And Company Quinoxaline compounds as hypnotic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/76 *
EXBK/78 *

Also Published As

Publication number Publication date
FR2439188A1 (fr) 1980-05-16
ES485221A1 (es) 1980-07-01
LU81798A1 (fr) 1980-04-21
ES485222A1 (es) 1980-09-01
IT1193847B (it) 1988-08-24
JPS5569514A (en) 1980-05-26
CA1145337A (fr) 1983-04-26
IT7926662A0 (it) 1979-10-19
IL58478A0 (en) 1980-01-31
PH15791A (en) 1983-03-25
DD146705A5 (de) 1981-02-25
BE879472A (fr) 1980-04-18
EP0010426A1 (fr) 1980-04-30
GB2034302A (en) 1980-06-04
AU5197779A (en) 1980-05-01
PT70340A (en) 1979-10-01
RO78225A (fr) 1982-02-01
FI793261A (fi) 1980-04-21
GR72941B (fr) 1984-01-16
DK444479A (da) 1980-04-21
US4264600A (en) 1981-04-28

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