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FR2369296A1 - 5-FLUOROURACIL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION - Google Patents

5-FLUOROURACIL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Info

Publication number
FR2369296A1
FR2369296A1 FR7732748A FR7732748A FR2369296A1 FR 2369296 A1 FR2369296 A1 FR 2369296A1 FR 7732748 A FR7732748 A FR 7732748A FR 7732748 A FR7732748 A FR 7732748A FR 2369296 A1 FR2369296 A1 FR 2369296A1
Authority
FR
France
Prior art keywords
preparation process
therapeutic application
fluorouracil derivatives
fluorouracil
positions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7732748A
Other languages
French (fr)
Other versions
FR2369296B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP13020076A external-priority patent/JPS5356677A/en
Priority claimed from JP4321477A external-priority patent/JPS53135987A/en
Priority claimed from JP5849277A external-priority patent/JPS53144582A/en
Priority claimed from JP11037077A external-priority patent/JPS5444681A/en
Priority claimed from JP11086777A external-priority patent/JPS5444682A/en
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of FR2369296A1 publication Critical patent/FR2369296A1/en
Application granted granted Critical
Publication of FR2369296B1 publication Critical patent/FR2369296B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Dérivés de 5-fluorouracile présentant un résidu glycosidique à l'une des positions O** 2- et O**4- et un atome d'hydrogène ou un groupe yrotecteur du groupe hydroxy à l'autre des positions O**2- et O**4 -. Ces composés présentent une activité antitumorale intéressante ou sont des interpédiaires pour la synthèse d'agents antitumoraux et peuvent être préparés en faisant réagir un sel métallique du dérivé de 5-fluorouracile correspondant avec l'halogénure de glycosyle correspondant.5-Fluorouracil derivatives having a glycosidic residue at one of the O ** 2- and O ** 4- positions and a hydrogen atom or a hydroxy-protecting group at the other of the O ** 2- positions and O ** 4 -. These compounds exhibit interesting anti-tumor activity or are intermediates for the synthesis of anti-tumor agents and can be prepared by reacting a metal salt of the corresponding 5-fluorouracil derivative with the corresponding glycosyl halide.

FR7732748A 1976-10-28 1977-10-28 5-FLUOROURACIL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION Granted FR2369296A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP13020076A JPS5356677A (en) 1976-10-28 1976-10-28 5-fluorouracil derivatives
JP4321477A JPS53135987A (en) 1977-04-15 1977-04-15 5-fluorouracil derivative
JP5849277A JPS53144582A (en) 1977-05-20 1977-05-20 5-fluorouracil derivatives
JP11037077A JPS5444681A (en) 1977-09-13 1977-09-13 5-fluororacil derivative
JP11086777A JPS5444682A (en) 1977-09-14 1977-09-14 5-fluorouracil derivative

Publications (2)

Publication Number Publication Date
FR2369296A1 true FR2369296A1 (en) 1978-05-26
FR2369296B1 FR2369296B1 (en) 1982-06-11

Family

ID=27522306

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7732748A Granted FR2369296A1 (en) 1976-10-28 1977-10-28 5-FLUOROURACIL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Country Status (6)

Country Link
CH (3) CH642974A5 (en)
DE (1) DE2748562A1 (en)
DK (1) DK149818C (en)
FR (1) FR2369296A1 (en)
GB (1) GB1541185A (en)
NL (1) NL7711911A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL122700A0 (en) * 1995-06-23 1998-12-06 Oxford Glycosciences Uk Ltd Pyranosyl conjugates for delivery of active moieties
GB9626450D0 (en) * 1996-12-20 1997-02-05 Oxford Glycosciences Uk Ltd Therapeutic compounds
EP1405859A4 (en) 2001-06-20 2008-01-23 Kissei Pharmaceutical Nitrogenous heterocyclic derivative, medicinal composition containing the same, medicinal use thereof and intermediate therefor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1978 *
EXBK/ *

Also Published As

Publication number Publication date
DK149818B (en) 1986-10-06
DE2748562A1 (en) 1978-05-03
FR2369296B1 (en) 1982-06-11
GB1541185A (en) 1979-02-21
DK149818C (en) 1987-04-06
CH650006A5 (en) 1985-06-28
DK478177A (en) 1978-04-29
CH642974A5 (en) 1984-05-15
CH643272A5 (en) 1984-05-30
NL7711911A (en) 1978-05-03

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Legal Events

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