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FR2374307A1 - 1,4-DIHYDROPYRIDINE DERIVATIVES, THE PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM - Google Patents

1,4-DIHYDROPYRIDINE DERIVATIVES, THE PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

Info

Publication number
FR2374307A1
FR2374307A1 FR7738126A FR7738126A FR2374307A1 FR 2374307 A1 FR2374307 A1 FR 2374307A1 FR 7738126 A FR7738126 A FR 7738126A FR 7738126 A FR7738126 A FR 7738126A FR 2374307 A1 FR2374307 A1 FR 2374307A1
Authority
FR
France
Prior art keywords
obtaining
pharmaceutical composition
composition containing
dihydropyridine derivatives
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738126A
Other languages
French (fr)
Other versions
FR2374307B1 (en
Inventor
Yoshinari Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of FR2374307A1 publication Critical patent/FR2374307A1/en
Application granted granted Critical
Publication of FR2374307B1 publication Critical patent/FR2374307B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés de la 1,4-dihydropyridine. Ces composés répondent à la formule :The invention relates to novel derivatives of 1,4-dihydropyridine. These compounds correspond to the formula:

FR7738126A 1976-12-17 1977-12-16 1,4-DIHYDROPYRIDINE DERIVATIVES, THE PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM Granted FR2374307A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52720/76A GB1591089A (en) 1976-12-17 1976-12-17 1,4-dihydropyridine derivatives and process for preparation thereof

Publications (2)

Publication Number Publication Date
FR2374307A1 true FR2374307A1 (en) 1978-07-13
FR2374307B1 FR2374307B1 (en) 1981-02-13

Family

ID=10465031

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738126A Granted FR2374307A1 (en) 1976-12-17 1977-12-16 1,4-DIHYDROPYRIDINE DERIVATIVES, THE PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

Country Status (15)

Country Link
JP (1) JPS5948828B2 (en)
AR (2) AR221478A1 (en)
AT (1) AT367401B (en)
AU (1) AU518206B2 (en)
BE (1) BE861964A (en)
CH (1) CH633266A5 (en)
DE (1) DE2756226A1 (en)
DK (2) DK563377A (en)
ES (3) ES465137A1 (en)
FR (1) FR2374307A1 (en)
GB (1) GB1591089A (en)
HU (1) HU176454B (en)
NL (1) NL7714066A (en)
SE (2) SE7714374L (en)
ZA (1) ZA777532B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2435471A1 (en) * 1978-09-08 1980-04-04 Fujisawa Pharmaceutical Co DIHYDROPYRIDINE DERIVATIVES, PROCESSES FOR OBTAINING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2438654A1 (en) * 1978-10-10 1980-05-09 Fujisawa Pharmaceutical Co 2-METHYL-DIHYDROPYRIDINE COMPOUND, METHODS FOR OBTAINING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
FR2523128A1 (en) * 1982-03-10 1983-09-16 Sandoz Sa NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2935451A1 (en) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
DE3018259A1 (en) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-DIHYDROPYRIDINE WITH DIFFERENT SUBSTITUENTS IN 2- AND 6-POSITIONS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
JPS57175164A (en) * 1981-04-18 1982-10-28 Banyu Pharmaceut Co Ltd 1,4-dihydropyridine derivative and its preparation
DE3269219D1 (en) * 1981-11-17 1986-03-27 Fisons Plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
HU192166B (en) * 1982-08-06 1987-05-28 Banyu Pharma Co Ltd Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
FI862343A (en) 1985-06-17 1986-12-18 Warner Lambert Co FRAME FOR THE PREPARATION OF THERAPEUTIC NETWORK 1,4-DIHYDROPYRIDIN INFOERING.
EP0226271B1 (en) * 1985-08-21 1990-11-22 GLAXO S.p.A. 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation
DE3544211A1 (en) * 1985-12-13 1987-06-19 Bayer Ag NEW, FLUORINE 1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
IT1204460B (en) * 1986-02-20 1989-03-01 Glaxo Spa HETEROCYCLIC DERIVATIVES
FR2596760B1 (en) * 1986-04-02 1988-12-09 Sori Soc Rech Ind DISSYMMETRIC DERIVATIVES OF 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID, METHODS OF PREPARATION AND THERAPEUTIC USE
US4732898A (en) * 1986-04-29 1988-03-22 Warner-Lambert Company 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
JPS63115890A (en) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd 2-substituted 1,4-dihydropyridine derivative
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
CN103951608B (en) * 2009-08-04 2016-04-27 喜德生（苏州）医药科技有限公司 Nilvadipine crystal formation and preparation method thereof
CN103254122B (en) * 2013-06-19 2015-04-22 湖南师范大学 Preparation method of cardiovascular drug nilvadipine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2236497A1 (en) * 1973-07-12 1975-02-07 Bayer Ag
FR2315930A1 (en) * 1975-07-02 1977-01-28 Fujisawa Pharmaceutical Co 1,4-DIHYDROPYRIDINE DERIVATIVES AND THEIR PREPARATION PROCESS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (en) * 1969-12-17 1971-06-24 Bayer Ag New cyanophenyl-1,4-dihydropyridine derivatives
US3946027A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
US3946028A (en) * 1972-09-30 1976-03-23 Bayer Aktiengesellschaft 2,3,5,6-Tetracarboxy-4-pyridyl-1,4-dihydropyridine derivatives
DE2248150A1 (en) * 1972-09-30 1974-04-04 Bayer Ag DIHYDROPYRIDINE POLYESTER, METHOD FOR MANUFACTURING AND USING THEM AS A MEDICINAL PRODUCT
CH607848A5 (en) * 1974-06-04 1978-11-30 Bayer Ag

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2236497A1 (en) * 1973-07-12 1975-02-07 Bayer Ag
FR2315930A1 (en) * 1975-07-02 1977-01-28 Fujisawa Pharmaceutical Co 1,4-DIHYDROPYRIDINE DERIVATIVES AND THEIR PREPARATION PROCESS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2435471A1 (en) * 1978-09-08 1980-04-04 Fujisawa Pharmaceutical Co DIHYDROPYRIDINE DERIVATIVES, PROCESSES FOR OBTAINING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2438654A1 (en) * 1978-10-10 1980-05-09 Fujisawa Pharmaceutical Co 2-METHYL-DIHYDROPYRIDINE COMPOUND, METHODS FOR OBTAINING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
FR2523128A1 (en) * 1982-03-10 1983-09-16 Sandoz Sa NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE DERIVATIVES

Also Published As

Publication number Publication date
ZA777532B (en) 1978-10-25
AU518206B2 (en) 1981-09-17
SE7714374L (en) 1978-06-18
DK172182A (en) 1982-04-16
ES474234A1 (en) 1979-04-01
JPS5395977A (en) 1978-08-22
DK563377A (en) 1978-06-18
SE8204312D0 (en) 1982-07-13
AR221478A1 (en) 1981-02-13
CH633266A5 (en) 1982-11-30
HU176454B (en) 1981-03-28
GB1591089A (en) 1981-06-10
DE2756226A1 (en) 1978-06-29
AU3165777A (en) 1979-06-21
NL7714066A (en) 1978-06-20
ATA901877A (en) 1981-11-15
AT367401B (en) 1982-07-12
AR221887A1 (en) 1981-03-31
JPS5948828B2 (en) 1984-11-29
ES474233A1 (en) 1979-11-01
ES465137A1 (en) 1979-01-01
SE8204312L (en) 1982-07-13
BE861964A (en) 1978-06-16
FR2374307B1 (en) 1981-02-13

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Legal Events

Date Code Title Description
ST Notification of lapse