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FR2152722A1 - Alkoxy acetoacetate prepn - from haloacetoacetates and alkali alcoholates in alcohols - Google Patents

Alkoxy acetoacetate prepn - from haloacetoacetates and alkali alcoholates in alcohols

Info

Publication number
FR2152722A1
FR2152722A1 FR7231729A FR7231729A FR2152722A1 FR 2152722 A1 FR2152722 A1 FR 2152722A1 FR 7231729 A FR7231729 A FR 7231729A FR 7231729 A FR7231729 A FR 7231729A FR 2152722 A1 FR2152722 A1 FR 2152722A1
Authority
FR
France
Prior art keywords
haloacetoacetates
prepn
acetoacetate
alkoxy
alcohols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7231729A
Other languages
French (fr)
Other versions
FR2152722B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of FR2152722A1 publication Critical patent/FR2152722A1/en
Application granted granted Critical
Publication of FR2152722B1 publication Critical patent/FR2152722B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C07C69/72—Acetoacetic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Gamma-Alkoxyacetoacetates of formula ROCH2CHR1COOR2 (I) (where R and R2 are alkyl, R1 is H or alkyl) are prepd. in high yields by reacting 1 mole of a gamma-haloacetoacetate, esp. a gamma-chloroacetoacetate, with >=2 (2.5-5) moles of an alkali alcoholate dissolved in an alcohol, and sepg. (I) from reaction mixt. Reaction takes place at esp. 15-30 degrees C pref. in presence of a further aprotic solvent, partic. DMSO esp. used in amts. corresp. to vol. of alcohol used.
FR7231729A 1971-09-10 1972-09-07 Alkoxy acetoacetate prepn - from haloacetoacetates and alkali alcoholates in alcohols Granted FR2152722A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1327771A CH562191A5 (en) 1971-09-10 1971-09-10

Publications (2)

Publication Number Publication Date
FR2152722A1 true FR2152722A1 (en) 1973-04-27
FR2152722B1 FR2152722B1 (en) 1978-02-10

Family

ID=4390993

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7231729A Granted FR2152722A1 (en) 1971-09-10 1972-09-07 Alkoxy acetoacetate prepn - from haloacetoacetates and alkali alcoholates in alcohols

Country Status (13)

Country Link
JP (1) JPS5318485B2 (en)
AT (1) AT317165B (en)
BE (1) BE788516A (en)
CA (1) CA1003434A (en)
CH (1) CH562191A5 (en)
CS (1) CS158734B2 (en)
DD (1) DD99157A5 (en)
DE (1) DE2244012C3 (en)
FR (1) FR2152722A1 (en)
IT (1) IT965273B (en)
LU (1) LU66030A1 (en)
NL (1) NL178866C (en)
SU (1) SU430544A3 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3261768D1 (en) * 1981-10-01 1985-02-14 Lonza Ag Process for the preparation of 4-alkoxy-aceto-acetic-acid esters
EP0076379B1 (en) * 1981-10-01 1985-05-15 Lonza Ag Process for the preparation of 4-alkoxy-acetoacetic-acid esters
WO1987003287A2 (en) * 1985-11-20 1987-06-04 L. Givaudan & Cie Societe Anonyme PROCESS FOR PREPARING alpha-HYDROXY CARBONYL COMPOUNDS
PT3608325T (en) 2012-12-21 2022-10-17 Gilead Sciences Inc Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
NO2865735T3 (en) 2013-07-12 2018-07-21
PT3019503T (en) 2013-07-12 2017-11-27 Gilead Sciences Inc Polycyclic-carbamoylpyridone compounds and their use for the treatment of hiv infections
TWI677489B (en) 2014-06-20 2019-11-21 美商基利科學股份有限公司 Synthesis of polycyclic-carbamoylpyridone compounds
NO2717902T3 (en) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Also Published As

Publication number Publication date
NL178866C (en) 1986-06-02
JPS5318485B2 (en) 1978-06-15
BE788516A (en) 1973-03-07
NL7212180A (en) 1973-03-13
IT965273B (en) 1974-01-31
DE2244012B2 (en) 1981-06-25
CH562191A5 (en) 1975-05-30
DD99157A5 (en) 1973-07-20
AT317165B (en) 1974-08-12
SU430544A3 (en) 1974-05-30
DE2244012C3 (en) 1982-02-25
NL178866B (en) 1986-01-02
JPS4834819A (en) 1973-05-22
DE2244012A1 (en) 1973-03-15
CA1003434A (en) 1977-01-11
CS158734B2 (en) 1974-11-25
FR2152722B1 (en) 1978-02-10
LU66030A1 (en) 1973-03-12

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