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FI930773A - En kemisk process - Google Patents

En kemisk process Download PDF

Info

Publication number
FI930773A
FI930773A FI930773A FI930773A FI930773A FI 930773 A FI930773 A FI 930773A FI 930773 A FI930773 A FI 930773A FI 930773 A FI930773 A FI 930773A FI 930773 A FI930773 A FI 930773A
Authority
FI
Finland
Prior art keywords
phenyl
chemical process
trinor
dihydro
stands
Prior art date
Application number
FI930773A
Other languages
English (en)
Other versions
FI104895B (fi
FI930773A0 (fi
Inventor
Jozsef Ivanics
Tibor Szabo
Istvan Hermecz
Gyula Dalmadi
Jozsefine Ivanics
Gaborne Kovacs
Resul Bahram
Original Assignee
Kabi Pharmacia Ab
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab, Chinoin Gyogyszer Es Vegyeszet filed Critical Kabi Pharmacia Ab
Publication of FI930773A publication Critical patent/FI930773A/fi
Publication of FI930773A0 publication Critical patent/FI930773A0/fi
Application granted granted Critical
Publication of FI104895B publication Critical patent/FI104895B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Emergency Lowering Means (AREA)
FI930773A 1991-06-24 1993-02-22 Kemiallinen menetelmä FI104895B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU209291 1991-06-24
HU912092A HU212570B (en) 1991-06-24 1991-06-24 Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
HU9200025 1992-06-19
PCT/HU1992/000025 WO1993000329A1 (en) 1991-06-24 1992-06-19 Chemical process

Publications (3)

Publication Number Publication Date
FI930773A true FI930773A (fi) 1993-02-22
FI930773A0 FI930773A0 (fi) 1993-02-22
FI104895B FI104895B (fi) 2000-04-28

Family

ID=10957725

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930773A FI104895B (fi) 1991-06-24 1993-02-22 Kemiallinen menetelmä

Country Status (23)

Country Link
US (1) US5466833A (fi)
EP (1) EP0544899B1 (fi)
JP (1) JP2635213B2 (fi)
KR (1) KR0163022B1 (fi)
CN (1) CN1035764C (fi)
AT (1) ATE127450T1 (fi)
AU (1) AU656994B2 (fi)
BG (1) BG61261B1 (fi)
CZ (1) CZ287168B6 (fi)
DE (1) DE69204627T2 (fi)
DK (1) DK0544899T3 (fi)
ES (1) ES2078055T3 (fi)
FI (1) FI104895B (fi)
GR (1) GR3017874T3 (fi)
HU (1) HU212570B (fi)
IE (1) IE71645B1 (fi)
IL (1) IL102280A (fi)
PL (1) PL170728B1 (fi)
RO (1) RO117323B1 (fi)
RU (1) RU2099325C1 (fi)
TW (1) TW310321B (fi)
UA (1) UA39864C2 (fi)
WO (1) WO1993000329A1 (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510383A (en) 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
US6225348B1 (en) 1998-08-20 2001-05-01 Alfred W. Paulsen Method of treating macular degeneration with a prostaglandin derivative
IL143477A (en) 2001-05-31 2009-07-20 Finetech Pharmaceutical Ltd Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
IL134241A (en) * 2000-01-27 2006-06-11 Finetech Pharmaceutical Ltd Process for the preparation of latanoprost
GB0112699D0 (en) 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
US20110065129A1 (en) * 2001-07-27 2011-03-17 Lowe Derek B Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
ITRM20050231A1 (it) * 2005-05-13 2006-11-14 Technopharma Sa Procedimento per la sintesi di derivati delle prostaglandine f.
US8546114B2 (en) 2006-01-18 2013-10-01 Chirogate International Inc. Processes for the preparation of optically active cyclopentenones and cyclopentenones prepared therefrom
US7511168B2 (en) 2006-01-18 2009-03-31 Shih-Yi Wei Processes and intermediates for the preparations of prostaglandins
JP2008037782A (ja) * 2006-08-04 2008-02-21 Daiichi Fine Chemical Co Ltd プロスタグランジン誘導体の製造方法
US7642370B2 (en) 2006-08-07 2010-01-05 Daiichi Fine Chemical Co., Ltd. Method for preparing prostaglandin derivative
IT1392492B1 (it) 2008-12-24 2012-03-09 Ind Chimica Srl Processo per la purificazione del latanoprost, analogo sintetico della prostaglandina pgf2alfa.
PT2523669T (pt) * 2010-01-11 2017-01-31 Inotek Pharmaceuticals Corp Associação, conjunto ( kit ) e método de redução da pressão intraocular
JP2013523739A (ja) 2010-03-26 2013-06-17 イノテック ファーマシューティカルズ コーポレイション N6−シクロペンチルアデノシン(cpa)、cpa誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法
EP2495235B1 (en) 2011-03-04 2015-08-05 Newchem S.p.A. Process for the synthesis of prostaglandins and intermediates thereof
CA2837261C (en) * 2011-06-02 2020-12-15 CHINOIN Zrt. Novel processes for the preparation of prostaglandin amides
HU231203B1 (hu) 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
ES2637332T3 (es) 2012-01-26 2017-10-11 Inotek Pharmaceuticals Corporation Polimorfos anhidros de nitrato de (2R,3S,4R,5R)-5-(6-(ciclopentilamino)-9H-purin-9-il)-3,4-dihidroxitetrahidrofuran-2-il)}metilo y procedimientos de preparación del mismo
HU230744B1 (hu) 2012-11-30 2018-01-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
CA2903114A1 (en) 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations
HU231214B1 (hu) 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE786251A (fr) * 1971-07-14 1973-01-15 Ici Ltd Nouveaux derives du cyclopentane
US3971826A (en) * 1972-07-13 1976-07-27 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandins
ES2193901T1 (es) * 1988-09-06 2003-11-16 Pharmacia Ab Derivados de prostaglandina para el tratamiento de glaucoma o hipertension ocular.

Also Published As

Publication number Publication date
DE69204627T2 (de) 1996-05-02
BG97471A (bg) 1994-03-24
WO1993000329A1 (en) 1993-01-07
FI104895B (fi) 2000-04-28
CZ287168B6 (en) 2000-10-11
CZ27193A3 (en) 1993-10-13
UA39864C2 (uk) 2001-07-16
JP2635213B2 (ja) 1997-07-30
BG61261B1 (en) 1997-04-30
TW310321B (fi) 1997-07-11
CN1035764C (zh) 1997-09-03
IE922026A1 (en) 1992-12-30
HUT62561A (en) 1993-05-28
IE71645B1 (en) 1997-02-26
US5466833A (en) 1995-11-14
FI930773A0 (fi) 1993-02-22
JPH06500804A (ja) 1994-01-27
CN1072408A (zh) 1993-05-26
DE69204627D1 (de) 1995-10-12
HU912092D0 (en) 1991-12-30
RU2099325C1 (ru) 1997-12-20
DK0544899T3 (da) 1995-10-23
GR3017874T3 (en) 1996-01-31
EP0544899B1 (en) 1995-09-06
HU212570B (en) 1996-08-29
IL102280A (en) 1998-02-08
AU656994B2 (en) 1995-02-23
ES2078055T3 (es) 1995-12-01
ATE127450T1 (de) 1995-09-15
PL170728B1 (pl) 1997-01-31
EP0544899A1 (en) 1993-06-09
AU2262992A (en) 1993-01-25
KR0163022B1 (ko) 1999-01-15
PL298127A1 (en) 1994-01-24
RO117323B1 (ro) 2002-01-30

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: PHARMACIA & UPJOHN AKTIEBOLAG

MA Patent expired