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FI925131A0 - Derivat av rekombinant human faktor viii - Google Patents

Derivat av rekombinant human faktor viii

Info

Publication number
FI925131A0
FI925131A0 FI925131A FI925131A FI925131A0 FI 925131 A0 FI925131 A0 FI 925131A0 FI 925131 A FI925131 A FI 925131A FI 925131 A FI925131 A FI 925131A FI 925131 A0 FI925131 A0 FI 925131A0
Authority
FI
Finland
Prior art keywords
derivatives
recombinant human
factor viii
human factor
viii
Prior art date
Application number
FI925131A
Other languages
English (en)
Other versions
FI925131A (fi
FI107539B (fi
Inventor
Annelie B Almstedt
Eva Maria Gray
Peter Lind
Catherine Ljung
Helena Inga Sandberg
Jack Spira
Mona Sydow-Baeckman
Helena Wiman
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Publication of FI925131A0 publication Critical patent/FI925131A0/fi
Publication of FI925131A publication Critical patent/FI925131A/fi
Application granted granted Critical
Publication of FI107539B publication Critical patent/FI107539B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Mold Materials And Core Materials (AREA)
  • Molds, Cores, And Manufacturing Methods Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI925131A 1991-03-15 1992-11-11 Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu FI107539B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9100799A SE468050C (sv) 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII
SE9100799 1991-03-15
PCT/SE1992/000150 WO1992016557A1 (en) 1991-03-15 1992-03-11 Recombinant human factor viii derivatives
SE9200150 1992-03-11

Publications (3)

Publication Number Publication Date
FI925131A0 true FI925131A0 (fi) 1992-11-11
FI925131A FI925131A (fi) 1992-11-11
FI107539B FI107539B (fi) 2001-08-31

Family

ID=20382191

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925131A FI107539B (fi) 1991-03-15 1992-11-11 Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu

Country Status (17)

Country Link
EP (1) EP0533862B1 (fi)
JP (1) JP2655752B2 (fi)
AR (1) AR247590A1 (fi)
AT (1) ATE186055T1 (fi)
AU (1) AU650730B2 (fi)
CA (1) CA2081659C (fi)
DE (1) DE69230206T2 (fi)
DK (1) DK0533862T3 (fi)
ES (1) ES2137182T3 (fi)
FI (1) FI107539B (fi)
GR (1) GR3032468T3 (fi)
IE (1) IE920814A1 (fi)
NO (1) NO308174B1 (fi)
PT (1) PT100245B (fi)
SE (1) SE468050C (fi)
WO (1) WO1992016557A1 (fi)
ZA (1) ZA921882B (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5364771A (en) * 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US5663060A (en) * 1992-04-07 1997-09-02 Emory University Hybrid human/animal factor VIII
US5744446A (en) * 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
ES2127829T3 (es) 1992-07-31 1999-05-01 Medeva Holdings Bv Expresion de proteinas recombinantes fusionadas en bacterias atenuadas.
SE9300509D0 (sv) * 1993-02-16 1993-02-16 Kabi Pharmacia Ab Peg treatment
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
GB9401787D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
SE9303601D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Improved cell cultivation method and medium
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
EP1048726B1 (en) * 1999-04-27 2006-07-26 Négrier, Claude Modified factor VIII cDNA
EP1038959A1 (en) * 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
EP1233064A1 (en) 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
EP1284290A1 (en) * 2001-08-08 2003-02-19 Aventis Behring GmbH Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA
EP1283263A1 (en) * 2001-08-08 2003-02-12 Aventis Behring GmbH Modified cDNA for high expression levels of factor VIII and its derivatives
HUE033158T2 (en) 2003-09-30 2017-11-28 Univ Pennsylvania Adeno-associated virus (AAV) clusters, sequences, vectors containing them, and their use
ES2525067T3 (es) 2005-04-07 2014-12-17 The Trustees Of The University Of Pennsylvania Método de incremento de la función de un vector de AAV
KR20080007226A (ko) * 2005-04-14 2008-01-17 체에스엘 베링 게엠베하 증가된 안정성을 가진 변형된 응고 인자 ⅷ 및 이의 유도체
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
SG10201502270TA (en) 2010-03-29 2015-05-28 Univ Pennsylvania Pharmacologically induced transgene ablation system
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
EP2675902B1 (en) 2011-02-17 2019-03-27 The Trustees Of The University Of Pennsylvania Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer
US9719106B2 (en) 2013-04-29 2017-08-01 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
CN105017410B (zh) * 2014-04-18 2018-06-08 北京诺思兰德生物技术股份有限公司 一种b区部分缺失型重组人凝血因子ⅷ
EP3283126B1 (en) 2015-04-16 2019-11-06 Emory University Recombinant promoters and vectors for protein expression in liver and use thereof
JP7382138B2 (ja) * 2016-10-03 2023-11-16 第一三共株式会社 Ｈｓｐａ５遺伝子のプロモーター
CN116209430A (zh) 2020-08-07 2023-06-02 阿米库斯治疗学公司 囊泡靶向蛋白及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
JPS62181786A (ja) * 1985-08-12 1987-08-10 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 融合蛋白質の製造法
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
NO872932L (no) * 1986-07-18 1988-01-19 Gist Brocades Nv Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika.
NZ219516A (en) * 1987-02-10 1991-02-26 Wellcome Found Fusion proteins of hbcag (hepatitis b virus core antigen)
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
HUT64591A (en) * 1989-11-17 1994-01-28 Novo Nordisk As Protein complexes with viii/c factor activity and process for their production
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex

Also Published As

Publication number Publication date
AU650730B2 (en) 1994-06-30
AR247590A1 (es) 1995-01-31
SE468050B (sv) 1992-10-26
DE69230206D1 (de) 1999-12-02
IE920814A1 (en) 1992-09-23
ES2137182T3 (es) 1999-12-16
DK0533862T3 (da) 2000-01-17
DE69230206T2 (de) 2000-05-18
PT100245B (pt) 1999-08-31
CA2081659C (en) 2002-06-25
NO924395D0 (no) 1992-11-13
GR3032468T3 (en) 2000-05-31
NO924395L (no) 1993-01-13
WO1992016557A1 (en) 1992-10-01
ZA921882B (en) 1992-11-25
CA2081659A1 (en) 1992-09-16
SE468050C (sv) 1998-04-27
EP0533862B1 (en) 1999-10-27
PT100245A (pt) 1993-07-30
NO308174B1 (no) 2000-08-07
FI925131A (fi) 1992-11-11
JPH05507420A (ja) 1993-10-28
AU1351392A (en) 1992-10-21
FI107539B (fi) 2001-08-31
SE9100799L (sv) 1992-09-16
ATE186055T1 (de) 1999-11-15
JP2655752B2 (ja) 1997-09-24
EP0533862A1 (en) 1993-03-31
SE9100799D0 (sv) 1991-03-15

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: PHARMACIA & UPJOHN AKTIEBOLAG

HC Name/ company changed in application

Owner name: PHARMACIA & UPJOHN AKTIEBOLAG

MA Patent expired