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SE9403915D0 - Process A - Google Patents

Process A

Info

Publication number
SE9403915D0
SE9403915D0 SE9403915A SE9403915A SE9403915D0 SE 9403915 D0 SE9403915 D0 SE 9403915D0 SE 9403915 A SE9403915 A SE 9403915A SE 9403915 A SE9403915 A SE 9403915A SE 9403915 D0 SE9403915 D0 SE 9403915D0
Authority
SE
Sweden
Prior art keywords
factor viii
pct
date
recombinant
protease
Prior art date
Application number
SE9403915A
Other languages
English (en)
Original Assignee
Annelie Almstedt
Helena Sandberg
Maria Wrangel
Anna Oestlin
Anna Lisa Smeds
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Annelie Almstedt, Helena Sandberg, Maria Wrangel, Anna Oestlin, Anna Lisa Smeds filed Critical Annelie Almstedt
Priority to SE9403915A priority Critical patent/SE9403915D0/sv
Publication of SE9403915D0 publication Critical patent/SE9403915D0/sv
Priority to DE69534383T priority patent/DE69534383T2/de
Priority to JP51599396A priority patent/JP3787154B2/ja
Priority to NZ295811A priority patent/NZ295811A/en
Priority to CA2202875A priority patent/CA2202875C/en
Priority to MX9703552A priority patent/MX9703552A/es
Priority to EP95937286A priority patent/EP0784633B1/en
Priority to AU39439/95A priority patent/AU691692B2/en
Priority to PCT/SE1995/001351 priority patent/WO1996015150A1/en
Priority to AT95937286T priority patent/ATE302216T1/de
Priority to US08/809,756 priority patent/US5831026A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y10S530/831—Cohn fractions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
SE9403915A 1994-11-14 1994-11-14 Process A SE9403915D0 (sv)

Priority Applications (11)

Application Number Priority Date Filing Date Title
SE9403915A SE9403915D0 (sv) 1994-11-14 1994-11-14 Process A
US08/809,756 US5831026A (en) 1994-11-14 1995-11-14 Process for purifying factor VIII
CA2202875A CA2202875C (en) 1994-11-14 1995-11-14 Process for purifying factor viii
JP51599396A JP3787154B2 (ja) 1994-11-14 1995-11-14 Ｖｉｉｉ因子の精製方法
NZ295811A NZ295811A (en) 1994-11-14 1995-11-14 Protease resistant factor viii composition containing inhibitors of zinc dependent proteases added to a solution after harvest
DE69534383T DE69534383T2 (de) 1994-11-14 1995-11-14 Verfahren zur aufreinigung des faktors viii
MX9703552A MX9703552A (es) 1994-11-14 1995-11-14 Proceso de purificacion de factor viii.
EP95937286A EP0784633B1 (en) 1994-11-14 1995-11-14 Process for purifying factor viii
AU39439/95A AU691692B2 (en) 1994-11-14 1995-11-14 Process for purifying factor VIII
PCT/SE1995/001351 WO1996015150A1 (en) 1994-11-14 1995-11-14 Process for purifying factor viii
AT95937286T ATE302216T1 (de) 1994-11-14 1995-11-14 Verfahren zur aufreinigung des faktors viii

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9403915A SE9403915D0 (sv) 1994-11-14 1994-11-14 Process A

Publications (1)

Publication Number Publication Date
SE9403915D0 true SE9403915D0 (sv) 1994-11-14

Family

ID=20395964

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9403915A SE9403915D0 (sv) 1994-11-14 1994-11-14 Process A

Country Status (11)

Country Link
US (1) US5831026A (sv)
EP (1) EP0784633B1 (sv)
JP (1) JP3787154B2 (sv)
AT (1) ATE302216T1 (sv)
AU (1) AU691692B2 (sv)
CA (1) CA2202875C (sv)
DE (1) DE69534383T2 (sv)
MX (1) MX9703552A (sv)
NZ (1) NZ295811A (sv)
SE (1) SE9403915D0 (sv)
WO (1) WO1996015150A1 (sv)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605222B1 (en) * 1998-05-20 2003-08-12 Baxter Aktiengesellschaft Method for producing a factor VIII/von Willebrand factor complex
PL203177B1 (pl) 1999-02-22 2009-09-30 Baxter Int Sposób liofilizacji wodnego preparatu farmaceutycznego
WO2000056918A1 (fr) * 1999-03-19 2000-09-28 Yamanouchi Pharmaceutical Co., Ltd. Procede d'analyse d'inhibiteurs de cysteine protease
US6338964B1 (en) * 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration
WO2003055512A1 (en) 2001-12-21 2003-07-10 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
KR20040065278A (ko) * 2001-12-21 2004-07-21 노보 노르디스크 에이/에스 변경된 인자 ⅶ 폴리펩티드의 액체 조성물
US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
HUE037603T2 (hu) 2002-06-21 2018-09-28 Novo Nordisk Healthcare Ag VIIa faktor polipeptideket tartalmazó stabilizált, szilárd készítmények
BRPI0408439A (pt) * 2003-03-18 2006-04-04 Novo Nordisk Healthcare Ag composição farmacêutica lìquida aquosa, método para preparar e uso da mesma, método para tratar uma sìndrome responsiva ao fator vii, e, recipiente hermético
US7897734B2 (en) * 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
MXPA05012476A (es) * 2003-05-23 2006-02-22 Novo Nordisk Healthcare Ag Estabilizacion de proteina en solucion.
EP1641487B1 (en) * 2003-06-25 2012-02-29 Novo Nordisk Health Care AG Liquid composition of factor vii polypeptides
JP5306597B2 (ja) * 2003-07-01 2013-10-02 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチドの液体水性薬学的組成物
JP5653572B2 (ja) * 2003-08-14 2015-01-14 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチドの液状水性医薬組成物
ES2229931B1 (es) * 2003-10-03 2006-01-16 Grifols, S.A. Composicion liquida bilogicamente estable de fviii, de fvw o del complejo fviii/fvw humanos.
EP2311437A1 (en) * 2003-12-19 2011-04-20 Novo Nordisk Health Care AG Stabilised compositions of factor VII polypeptides
EP1707634A1 (en) 2005-03-29 2006-10-04 Octapharma AG Method for isolation of recombinantly produced proteins
WO2008135498A2 (en) * 2007-05-04 2008-11-13 Novo Nordisk A/S Prevention of protein degradation in mammalian cell cultures
EP2113564A1 (en) * 2008-05-01 2009-11-04 Arecor Limited Protein formulation
PL2300497T3 (pl) 2008-06-24 2013-02-28 Octapharma Ag Sposób oczyszczania czynnika krzepnięcia VIII
CA2732423A1 (en) 2008-08-21 2010-02-25 Octapharma Ag Recombinantly produced human factor viii and ix
US20110178019A1 (en) * 2008-09-03 2011-07-21 Brita Rippner New protecting compositions for recombinantly produced factor viii
US20100168018A1 (en) 2008-11-07 2010-07-01 Baxter International Inc. Factor viii formulations
GB0915480D0 (en) 2009-09-04 2009-10-07 Arecor Ltd Stable formulation of factor viii
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289691A (en) * 1980-01-18 1981-09-15 The Canadian Red Cross Society Method of obtaining intermediate purity factor VIII
US4406886A (en) * 1983-01-14 1983-09-27 University Patents, Inc. Purification of antihemophilia factor VIII by precipitation with zinc ions
FI86885C (sv) * 1984-04-20 1992-10-26 Genentech Inc Förfarande för framställning av human rekombinantfaktor VIII och nukle insyrasekvenser och vektorer använd därtill
US5149787A (en) * 1984-05-22 1992-09-22 The Blood Center Research Foundation Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing
US4710381A (en) * 1984-05-22 1987-12-01 The Blood Center Of Southeastern Wisconsin Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
CA1329760C (en) * 1987-10-29 1994-05-24 Ted C. K. Lee Plasma and recombinant protein formulations in high ionic strength media
US4877608A (en) * 1987-11-09 1989-10-31 Rorer Pharmaceutical Corporation Pharmaceutical plasma protein formulations in low ionic strength media
US4981951A (en) * 1988-04-14 1991-01-01 Miles Inc. Lectin affinity chromatography of factor VIII
WO1990002175A1 (en) * 1988-08-16 1990-03-08 Novo Nordisk A/S A method of producing polypeptides by culturing eukaryotic cells in the presence of protease inhibitors
GB8827305D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
US5110907A (en) * 1989-08-01 1992-05-05 Alpha Therapeutic Corporation Factor viii complex purification using heparin affinity chromatography
DE3926034C3 (de) * 1989-08-07 1996-11-21 Behringwerke Ag Verfahren zur Herstellung eines stabilen Faktors VIII
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
IT1248723B (it) * 1990-06-12 1995-01-26 Scalvo S P A Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo
CA2100355A1 (en) * 1991-02-04 1992-08-05 Lynne H. Parker Botehlo Endothelin converting enzyme
SE468050C (sv) * 1991-03-15 1998-04-27 Pharmacia & Upjohn Ab Rekombinant derivat av human faktor VIII
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex
US5278289A (en) * 1991-11-12 1994-01-11 Johnson Alan J Antihemophilic factor stabilization
WO1993022336A1 (en) * 1992-04-30 1993-11-11 Alpha Therapeutic Corporation Improved solubilization and stabilization of factor viii complex
US5288853A (en) * 1992-04-30 1994-02-22 Alpha Therapeutic Corporation Factor viii purification process
GB9211538D0 (en) * 1992-06-01 1992-07-15 Blake David R Antiinflammatory agent
HU220194B (hu) * 1992-10-02 2001-11-28 Genetics Institute Inc. Koagulációs faktor VIII-at tartalmazó készítmény és eljárás előállítására
SE9301581D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Protein formulation
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
IL113010A0 (en) * 1994-03-31 1995-10-31 Pharmacia Ab Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration

Also Published As

Publication number Publication date
EP0784633B1 (en) 2005-08-17
JP3787154B2 (ja) 2006-06-21
CA2202875C (en) 2011-03-15
JPH10509144A (ja) 1998-09-08
ATE302216T1 (de) 2005-09-15
CA2202875A1 (en) 1996-05-23
NZ295811A (en) 1998-08-26
DE69534383T2 (de) 2006-05-24
AU3943995A (en) 1996-06-06
WO1996015150A1 (en) 1996-05-23
EP0784633A1 (en) 1997-07-23
AU691692B2 (en) 1998-05-21
MX9703552A (es) 1997-08-30
DE69534383D1 (de) 2005-09-22
US5831026A (en) 1998-11-03

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