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FI90205B - Förfarande för framställning av en piperidinoalkanol-ibuprofenkomposition innehållande farmaceutisk komposition - Google Patents

Förfarande för framställning av en piperidinoalkanol-ibuprofenkomposition innehållande farmaceutisk komposition Download PDF

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Publication number
FI90205B
FI90205B FI892640A FI892640A FI90205B FI 90205 B FI90205 B FI 90205B FI 892640 A FI892640 A FI 892640A FI 892640 A FI892640 A FI 892640A FI 90205 B FI90205 B FI 90205B
Authority
FI
Finland
Prior art keywords
tablet
layer
piperidinoalkanol
prepared
ibuprofen
Prior art date
Application number
FI892640A
Other languages
English (en)
Finnish (fi)
Other versions
FI892640A (sv
FI892640A0 (sv
FI90205C (sv
Inventor
David Francis Long
Herbert Schock
William Richard Nadler
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI892640A0 publication Critical patent/FI892640A0/sv
Publication of FI892640A publication Critical patent/FI892640A/sv
Application granted granted Critical
Publication of FI90205B publication Critical patent/FI90205B/sv
Publication of FI90205C publication Critical patent/FI90205C/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (10)

1. Förfarande för framställning av en medicintab-lett med flere skikt, i form av en fast enhetsdos, k ä n- 5 netecknat därav, att man framställer en tablett, som omfattar: a) ett skikt, som innehäller ca 25 - 400 mg ibupro-fen eller ett farmaceutiskt godtagbart sait därav i bland-ning med farmaceutiskt godtagbara exipienter; 10 b) ett skikt som innehäller ca 0,1 - 140 mg piperi- dinoalkanol eller ett farmaceutiskt godtagbart sait därav i blandning med farmaceutiskt godtagbara exipienter; och c) ett skikt som innehäller en farmaceutiskt god-tagbar exipient interfolierad mellan nämnda ibuprofen in-15 nehällande skikt och nämnda piperidinoalkanol innehällande skikt, för att bilda ett barriärskikt dem emellan, genom att bringa skikten tillsammans i ändamälsen-lig följd.
2. Förfarande enligt patentkravet 1, k ä n n e -20 tecknat därav, att man framställer en tablett, där barriärskiktet föreligger i en mängd av ca 5 - 40 vikt-% räknat pä tablettens totalvikt.
3. Förfarande enligt patentkravet 1, k ä n netecknat därav, att man framställer en tablett, där 25 barriärskiktet föreligger i en mängd av ca 5 - 30 vikt-% räknat pä tablettens totalvikt.
4. Förfarande enligt patentkravet 1, k ä n netecknat därav, att man framställer en tablett, där barriärskiktet föreligger i en mängd av ca 10 - 30 15 vikt-% räknat pä tablettens totalvikt.
5. Förfarande enligt patentkravet 4, k ä n netecknat därav, att man framställer en tablett, där barriärskiktet bestär av en diluent och bindmedel.
6. Förfarande enligt patentkravet 5, k ä n n e -35 tecknat därav, att man framställer en tablett där 9 Π / Lj o bindemedlet och diluenten utgörs av mikrokristallin cellu-losa.
7. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att ätminstone ett av skikten inne- 5 häller ett sympatikusstimulerande, svullnadshämmande me-del.
8. Förfarande enligt patentkravet 5, känne-t e c k n a t därav, att man framställer en tablett, där piperidinoalkanol-antihistaminskiktet ytterligare innehäl- 10 ler ett sympatikusstimulerande, svullnadshämmande medel.
9. Förfarande enligt patentkravet 8, känne-t e c k n a t därav, att man framställer en tablett, där det sympatikusstimulerande, svullnadshämmande medlet är pseudoefedrin, piperidinoalkanolen är a-[4 — (1,1-dimetyle- 15 tyl)fenyl]-4-(hydroxidifenylmetyl)-1-piperidinbutanol och ibuprofenet är 2-(p-isobutyl-fenyl)propionsyra, eller far-maceutiskt godtagbara sait därav.
10. Förfarande enligt patentkravet 9, känne-t e c k n a t därav, att man framställer en tablett där: 20 a) ibuprofen föreligger i en mängd av ca 100 - 300 mg; b) pseudoefedrin föreligger i en mängd av ca 15 -60 mg; och c) α-[4-(1,1-dimetyletyl)fenyl]-4-(hydroxidifenyl- 25 metyl)-1-piperidinbutanol föreligger i en mängd av ca 15 - 60 mg.
FI892640A 1988-06-01 1989-05-31 Förfarande för framställning av en piperidinoalkanol-ibuprofenkomposition innehållande farmaceutisk komposition FI90205C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20081788A 1988-06-01 1988-06-01
US20081788 1988-06-01
US34418389 1989-04-27
US07/344,183 US4999226A (en) 1988-06-01 1989-04-27 Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination

Publications (4)

Publication Number Publication Date
FI892640A0 FI892640A0 (sv) 1989-05-31
FI892640A FI892640A (sv) 1989-12-02
FI90205B true FI90205B (sv) 1993-09-30
FI90205C FI90205C (sv) 1994-01-10

Family

ID=26896133

Family Applications (1)

Application Number Title Priority Date Filing Date
FI892640A FI90205C (sv) 1988-06-01 1989-05-31 Förfarande för framställning av en piperidinoalkanol-ibuprofenkomposition innehållande farmaceutisk komposition

Country Status (17)

Country Link
US (1) US4999226A (sv)
EP (1) EP0348683B1 (sv)
JP (1) JP2757017B2 (sv)
KR (1) KR0126129B1 (sv)
CN (1) CN1038021A (sv)
AU (1) AU615751B2 (sv)
CA (1) CA1327011C (sv)
DE (1) DE68900378D1 (sv)
DK (1) DK174638B1 (sv)
ES (1) ES2037908T3 (sv)
FI (1) FI90205C (sv)
GR (1) GR3003477T3 (sv)
HU (1) HU202746B (sv)
IE (1) IE61182B1 (sv)
IL (1) IL90461A0 (sv)
NZ (1) NZ229325A (sv)
PT (1) PT90689B (sv)

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US5605930A (en) * 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
JPH069382A (ja) * 1992-04-17 1994-01-18 Takeda Chem Ind Ltd 安定化された固型製剤およびその製造方法
EP0674527A1 (en) * 1992-12-21 1995-10-04 The Procter & Gamble Company Use of s(+) antipodes of analgesic agents for the manufacture of a composition to treat respiratory disorders
HU219462B (hu) * 1993-06-14 2001-04-28 Janssen Pharmaceutica N.V. Asztemizolt és pszeudoefedrint tartalmazó, nyújtott hatású, filmbevonatos tabletták
US5691352A (en) * 1993-10-25 1997-11-25 Merrell Pharmaceuticals Inc. Stable pharmaceutical composition of terfenadine and ibuprofen
WO1995015751A1 (fr) * 1993-12-10 1995-06-15 Fujisawa Pharmaceutical Co., Ltd. Medicament a principes actifs combines antipyretique et analgesique
US5419917A (en) * 1994-02-14 1995-05-30 Andrx Pharmaceuticals, Inc. Controlled release hydrogel formulation
US5399356A (en) * 1994-03-24 1995-03-21 The Procter & Gamble Company Process for making solid dose forms containing bismuth
KR100405116B1 (ko) * 1995-02-28 2004-02-05 아벤티스 파마슈티칼스 인크. 피페리디노알칸올화합물에대한약제학적조성물
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US6077539A (en) * 1996-11-12 2000-06-20 Pozen, Inc. Treatment of migraine headache
RU2207879C2 (ru) * 1997-08-26 2003-07-10 Авентис Фармасьютикалз, Инк. Фармацевтическая композиция для объединения пиперидиноалканола с противоотечным агентом
MY125516A (en) * 1999-11-16 2006-08-30 Smithkline Beecham Plc Novel composition based on thiazolidinedione and metformin and use
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US20040018239A1 (en) * 2000-11-17 2004-01-29 Hajime Ishida Pharmaceutical preparation containing copolyvidone
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US7807197B2 (en) * 2002-09-28 2010-10-05 Mcneil-Ppc, Inc. Composite dosage forms having an inlaid portion
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US20050220877A1 (en) * 2004-03-31 2005-10-06 Patel Ashish A Bilayer tablet comprising an antihistamine and a decongestant
CN1993111A (zh) * 2004-05-21 2007-07-04 阿库-伯雷克技术公司 含有相对无活性片段的药片
EP1755563B1 (en) * 2004-05-21 2012-01-25 Accu-Break Technologies, Inc. Pharmaceutical tablets comprising two or more unitary segments
US8673352B2 (en) * 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form
BRPI0620863A8 (pt) 2005-12-29 2018-01-16 Osmotica Kereskedelmi Es Szolgaltato Kft comprimido em camadas com combinação de liberação tripla
US8246988B2 (en) 2009-01-05 2012-08-21 Mcneil-Ppc, Inc. Three layer tablet containing cetirizine, pseudoephedrine, and naproxen
WO2010078543A1 (en) * 2009-01-05 2010-07-08 Mcneil-Ppc, Inc. Tablet containing cetirizine pseudoephedrine, and naproxen containing a barrier layer
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Also Published As

Publication number Publication date
KR0126129B1 (ko) 1997-12-24
DE68900378D1 (de) 1991-12-05
GR3003477T3 (en) 1993-02-17
EP0348683A1 (en) 1990-01-03
FI892640A (sv) 1989-12-02
ES2037908T3 (es) 1993-07-01
IE61182B1 (en) 1994-10-05
JPH0228111A (ja) 1990-01-30
AU615751B2 (en) 1991-10-10
DK174638B1 (da) 2003-08-04
CA1327011C (en) 1994-02-15
DK265489D0 (da) 1989-05-31
NZ229325A (en) 1990-10-26
JP2757017B2 (ja) 1998-05-25
PT90689B (pt) 1993-12-31
HUT52367A (en) 1990-07-28
US4999226A (en) 1991-03-12
FI892640A0 (sv) 1989-05-31
CN1038021A (zh) 1989-12-20
IE891795L (en) 1989-12-01
FI90205C (sv) 1994-01-10
KR900017573A (ko) 1990-12-19
DK265489A (da) 1989-12-02
IL90461A0 (en) 1990-01-18
HU202746B (en) 1991-04-29
EP0348683B1 (en) 1991-10-30
AU3580089A (en) 1989-12-07
PT90689A (pt) 1989-12-29

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Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: MERRELL DOW PHARMACEUTICALS INC.

PC Transfer of assignment of patent

Owner name: AVENTIS INC.

Free format text: AVENTIS INC.

MA Patent expired