FI90415B - Förfarande för framställning av terapeutiskt användbara substituerade 2-(2-aminoetoximetyl)-4-(2-klorfenyl)-3-etoxikarbonyl-5-metoxikarbonyl-6-metyl-1,4-dihydropyridiner - Google Patents
Förfarande för framställning av terapeutiskt användbara substituerade 2-(2-aminoetoximetyl)-4-(2-klorfenyl)-3-etoxikarbonyl-5-metoxikarbonyl-6-metyl-1,4-dihydropyridiner Download PDFInfo
- Publication number
- FI90415B FI90415B FI882001A FI882001A FI90415B FI 90415 B FI90415 B FI 90415B FI 882001 A FI882001 A FI 882001A FI 882001 A FI882001 A FI 882001A FI 90415 B FI90415 B FI 90415B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- ethoxycarbonyl
- methoxycarbonyl
- chlorophenyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (5)
1. Framställningsförfarande för ett terapeutiskt ' användbart dihydropyridinderivat, eller ett farmaceutiskt 5 godtagbart sait därav, med formeln I H ίο / COOC.H,. ( 1 ) j li Tr 2 5 A JO f2 CH3 n CH2CXa2CH2NHCOCH2CH2CHCOR1 a 15 väri R1 är -OR2 eller -NH2, väri R2 är H, C1.6-alkyl, fenyl eller bensyl, kännetecknat därav, att amino-skyddsgruppen R avlägsnas frän en förening med formeln 20 V/C1 (A) CH COOCH J Tl Γτ 2 5 25. f® CH3 f C^20C^2C^',N^^'0<'ii2C‘^^<'iiC'0R ^ H väri R är en aminoskyddsgrupp och R1 betecknar samma som i 30 formeln I; efter nämnda förfarande omvandlas produkten med formeln I om sä önskas tili ett farmaceutiskt godtagbart sait.
2. Framställningsförfarande enligt patentkrav 1, 35 kännetecknat därav, att R1 är -OH. 26 9 0 4 1 5
3. Framställningsförfarande enligt patentkrav 1 eller 2, kännetecknat därav, att R är bensyl-oxikarbonyl eller t-butoxikarbonyl.
4. Framställningsförfarande enligt patentkrav 3, 5 kännetecknat därav, att bensyloxikarbonylgrup- pen avlägsnas genom katalytisk hydrering och t-butoxikar-bonylgruppen genom syrabehandling.
5. Framställningsförfarande enligt patentkrav 4, kännetecknat därav, att syran är väteklorid- 10 gas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8710493 | 1987-05-02 | ||
| GB878710493A GB8710493D0 (en) | 1987-05-02 | 1987-05-02 | Dihydropyridines |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI882001A0 FI882001A0 (sv) | 1988-04-28 |
| FI882001A FI882001A (sv) | 1988-11-03 |
| FI90415B true FI90415B (sv) | 1993-10-29 |
| FI90415C FI90415C (sv) | 1994-02-10 |
Family
ID=10616773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI882001A FI90415C (sv) | 1987-05-02 | 1988-04-28 | Förfarande för framställning av terapeutiskt användbara substituerade 2-(2-aminoetoximetyl)-4-(2-klorfenyl)-3-etoxikarbonyl-5-metoxikarbonyl-6-metyl-1,4-dihydropyridiner |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4806557A (sv) |
| EP (1) | EP0290211B1 (sv) |
| JP (1) | JPS63297365A (sv) |
| AT (1) | ATE66915T1 (sv) |
| CA (1) | CA1326672C (sv) |
| DE (1) | DE3864573D1 (sv) |
| DK (1) | DK172094B1 (sv) |
| ES (1) | ES2031595T3 (sv) |
| FI (1) | FI90415C (sv) |
| GB (1) | GB8710493D0 (sv) |
| GR (1) | GR3002767T3 (sv) |
| IE (1) | IE60055B1 (sv) |
| PT (1) | PT87361B (sv) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5270323A (en) * | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
| US6057344A (en) | 1991-11-26 | 2000-05-02 | Sepracor, Inc. | Methods for treating hypertension, and angina using optically pure (-) amlodipine |
| WO2001000622A1 (en) * | 1999-06-25 | 2001-01-04 | Vertex Pharmaceuticals Incorporated | Prodrugs of carbamate inhibitors of impdh |
| GB0008332D0 (en) * | 2000-04-04 | 2000-05-24 | Pfizer Ltd | Treament |
| US6521647B2 (en) | 2000-04-04 | 2003-02-18 | Pfizer Inc. | Treatment of renal disorders |
| US6653481B2 (en) | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
| AT5874U1 (de) | 2000-12-29 | 2003-01-27 | Bioorg Bv | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| BR0116553A (pt) | 2000-12-29 | 2004-02-03 | Pfizer Ltd | Composto, composição farmacêutica para tratamento de angina ou hipertensão, processo, processo para tratamento ou prevenção de angina ou hipertensão, composição de ingredientes farmaceuticamente ativos, composição farmacêutica para tratamento ou prevenção de angina ou hipertensão e processo para tratar ou prevenir angina ou hipertensão |
| MXPA03005884A (es) | 2000-12-29 | 2005-04-08 | Pfizer Ltd | Hemimaleato de amlodipina. |
| PL362660A1 (en) | 2000-12-29 | 2004-11-02 | Pfizer Limited | Process for making amlodipine maleate |
| CA2433193C (en) | 2000-12-29 | 2006-01-31 | Pfizer Limited | Amide derivative of amlodipine |
| MXPA03005882A (es) | 2000-12-29 | 2005-04-19 | Pfizer Ltd | Derivado amida de amlodipina. |
| CA2433181C (en) | 2000-12-29 | 2005-11-22 | Pfizer Limited | Amlodipine hemifumarate |
| US7335380B2 (en) | 2000-12-29 | 2008-02-26 | Synthon Ip Inc. | Amlodipine free base |
| EP1346214A2 (en) | 2000-12-29 | 2003-09-24 | Pfizer Limited | Reference standards and processes for determining the purity or stability of amlodipine maleate |
| US6699892B2 (en) | 2002-06-04 | 2004-03-02 | Yung Shin Pharmaceutical Industrial Co., Ltd. | Pharmaceutically acceptable salt of amlodipine and method of preparing the same |
| KR20040011751A (ko) * | 2002-07-30 | 2004-02-11 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100496436B1 (ko) * | 2002-07-30 | 2005-06-20 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100538641B1 (ko) * | 2002-07-30 | 2005-12-22 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100462304B1 (ko) * | 2002-07-30 | 2004-12-17 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR100467669B1 (ko) * | 2002-08-21 | 2005-01-24 | 씨제이 주식회사 | 암로디핀의 유기산염 |
| KR20130061148A (ko) | 2010-05-03 | 2013-06-10 | 티에스에이치 바이오팜 코포레이션 리미티드 | 고혈압 치료용 약학 조성물 및 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
| US4447613A (en) * | 1979-08-24 | 1984-05-08 | Zoecon Corporation | Pyridyl esters and thiolesters of aminoalkanoic acids |
| CS228917B2 (en) * | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| GB8306666D0 (en) * | 1983-03-10 | 1983-04-13 | Pfizer Ltd | Therapeutic agents |
| US4568677A (en) * | 1983-07-23 | 1986-02-04 | Pfizer Inc. | 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents |
-
1987
- 1987-05-02 GB GB878710493A patent/GB8710493D0/en active Pending
-
1988
- 1988-04-28 DK DK264388A patent/DK172094B1/da not_active IP Right Cessation
- 1988-04-28 FI FI882001A patent/FI90415C/sv not_active IP Right Cessation
- 1988-04-28 US US07/187,116 patent/US4806557A/en not_active Expired - Lifetime
- 1988-04-29 EP EP88303940A patent/EP0290211B1/en not_active Expired - Lifetime
- 1988-04-29 CA CA000565483A patent/CA1326672C/en not_active Expired - Fee Related
- 1988-04-29 ES ES198888303940T patent/ES2031595T3/es not_active Expired - Lifetime
- 1988-04-29 DE DE8888303940T patent/DE3864573D1/de not_active Expired - Lifetime
- 1988-04-29 PT PT87361A patent/PT87361B/pt not_active IP Right Cessation
- 1988-04-29 IE IE128388A patent/IE60055B1/en not_active IP Right Cessation
- 1988-04-29 AT AT88303940T patent/ATE66915T1/de not_active IP Right Cessation
- 1988-04-30 JP JP63108909A patent/JPS63297365A/ja active Granted
-
1991
- 1991-09-20 GR GR91401379T patent/GR3002767T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK234388A (da) | 1989-01-19 |
| JPS63297365A (ja) | 1988-12-05 |
| DE3864573D1 (en) | 1991-10-10 |
| IE881283L (en) | 1988-11-02 |
| ATE66915T1 (de) | 1991-09-15 |
| JPH0581588B2 (sv) | 1993-11-15 |
| PT87361A (pt) | 1989-05-31 |
| DK172094B1 (da) | 1997-10-20 |
| EP0290211B1 (en) | 1991-09-04 |
| DK234388D0 (da) | 1988-04-28 |
| EP0290211A1 (en) | 1988-11-09 |
| GB8710493D0 (en) | 1987-06-03 |
| FI882001A (sv) | 1988-11-03 |
| GR3002767T3 (en) | 1993-01-25 |
| US4806557A (en) | 1989-02-21 |
| FI882001A0 (sv) | 1988-04-28 |
| IE60055B1 (en) | 1994-05-18 |
| PT87361B (pt) | 1992-08-31 |
| FI90415C (sv) | 1994-02-10 |
| CA1326672C (en) | 1994-02-01 |
| ES2031595T3 (es) | 1992-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: PFIZER LIMITED |