[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

FI871288A0 - Förfarande för framställning av aprotinin med rekombinant-DNA-teknik och vid förfarandet användbart DNA, expressionsplasmid och värdcell - Google Patents

Förfarande för framställning av aprotinin med rekombinant-DNA-teknik och vid förfarandet användbart DNA, expressionsplasmid och värdcell

Info

Publication number
FI871288A0
FI871288A0 FI871288A FI871288A FI871288A0 FI 871288 A0 FI871288 A0 FI 871288A0 FI 871288 A FI871288 A FI 871288A FI 871288 A FI871288 A FI 871288A FI 871288 A0 FI871288 A0 FI 871288A0
Authority
FI
Finland
Prior art keywords
aprotinin
preparation
host cell
expression plasmid
cell suitable
Prior art date
Application number
FI871288A
Other languages
English (en)
Finnish (fi)
Other versions
FI871288A (sv
FI94876B (sv
FI94876C (sv
Inventor
Ernst-August Auerswald
Werner Schroeder
Eugen Schnabel
Wolfgang Bruns
Gerd Reinhardt
Michael Kotick
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI871288A0 publication Critical patent/FI871288A0/sv
Publication of FI871288A publication Critical patent/FI871288A/sv
Publication of FI94876B publication Critical patent/FI94876B/sv
Application granted granted Critical
Publication of FI94876C publication Critical patent/FI94876C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FI871288A 1986-03-26 1987-03-24 Förfarande för framställning av aprotinin med rekombinant-DNA-teknik och vid förfarandet användbart DNA, expressionsplasmid och värdcell FI94876C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8607523 1986-03-26
GB08607523A GB2188322A (en) 1986-03-26 1986-03-26 Aprotinin and analogues thereof produced by a recombinant host

Publications (4)

Publication Number Publication Date
FI871288A0 true FI871288A0 (sv) 1987-03-24
FI871288A FI871288A (sv) 1987-09-27
FI94876B FI94876B (sv) 1995-07-31
FI94876C FI94876C (sv) 1995-11-10

Family

ID=10595278

Family Applications (1)

Application Number Title Priority Date Filing Date
FI871288A FI94876C (sv) 1986-03-26 1987-03-24 Förfarande för framställning av aprotinin med rekombinant-DNA-teknik och vid förfarandet användbart DNA, expressionsplasmid och värdcell

Country Status (15)

Country Link
US (1) US4894436A (sv)
EP (1) EP0238993B1 (sv)
JP (1) JP2537507B2 (sv)
KR (2) KR950000302B1 (sv)
CN (1) CN1018793B (sv)
AT (1) ATE123301T1 (sv)
AU (1) AU600475B2 (sv)
CA (1) CA1338309C (sv)
DE (1) DE3751324D1 (sv)
DK (1) DK151687A (sv)
ES (1) ES2073390T3 (sv)
FI (1) FI94876C (sv)
GB (1) GB2188322A (sv)
IL (1) IL81964A (sv)
ZA (1) ZA872181B (sv)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2188933A (en) * 1986-04-10 1987-10-14 Bayer Ag Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby
US5654176A (en) * 1987-05-28 1997-08-05 Amrad Corporation Limited Fusion proteins containing glutathione-s-transferase
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
US5591603A (en) * 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
ATE103930T1 (de) * 1988-03-07 1994-04-15 Ciba Geigy Ag Modifizierte proteine.
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
US20060134087A1 (en) * 1988-09-02 2006-06-22 Dyax Corp. ITI-D1 Kunitz domain mutants as hNE inhibitors
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US7413537B2 (en) 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
US5231010A (en) * 1989-09-13 1993-07-27 Bayer Aktiengesellschaft Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
AU8740491A (en) * 1990-09-28 1992-04-28 Protein Engineering Corporation Proteinaceous anti-dental plaque agents
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
EP0486001A1 (en) * 1990-11-13 1992-05-20 Mochida Pharmaceutical Co., Ltd. Recombinant urinary trypsin inhibitor fragments and drug composition
AU1545692A (en) 1991-03-01 1992-10-06 Protein Engineering Corporation Process for the development of binding mini-proteins
WO1993002107A1 (en) * 1991-07-25 1993-02-04 Oriental Yeast Co., Ltd. Immunoglobulin-combining artificial protein
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US5824870A (en) * 1995-11-06 1998-10-20 Baszczynski; Chris Commercial production of aprotinin in plants
AU5187698A (en) * 1996-12-06 1998-06-29 Cancerforskningsfondet Af 1989 Inhibition of invasive remodelling
FR2774988B1 (fr) * 1998-02-16 2000-05-05 Commissariat Energie Atomique Procede de purification de la prpres a partir d'un echantillon biologique et ses applications
US7241730B2 (en) * 1998-08-27 2007-07-10 Universitat Zurich Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides
US7910550B2 (en) * 2004-04-16 2011-03-22 Stc.Unm Human kunitz-type inhibitor with enhanced antifibrinolytic activity
US7432238B2 (en) * 2004-04-16 2008-10-07 Stc.Unm Human Kunitz-type inhibitor with enhanced antifibrinolytic activity
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
PL2360258T3 (pl) * 2005-02-18 2015-03-31 Angiochem Inc Polipeptydy aprotyniny do transportowania związków przez barierę krew-mózg
CN100406558C (zh) * 2005-06-14 2008-07-30 吉林圣元科技有限责任公司 制备重组抑酶肽的方法
WO2007076537A2 (en) 2005-12-29 2007-07-05 The Regents Of The University Of California Methods and compositions related to mutant kunitz domain i of tfpi-2
WO2008110301A1 (de) * 2007-03-13 2008-09-18 Bayer Schering Pharma Aktiengesellschaft Aprotinin-varianten mit verbesserten eigenschaften
DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
EP3328908B1 (en) * 2015-07-31 2023-10-25 Rohm and Haas Company Oligomer seed for synthesis of unimodal acrylic bead particles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3309501A1 (de) * 1983-03-17 1984-09-20 Bayer Ag, 5090 Leverkusen Plasmid-vektoren zur klonierung, identifizierung und expression von genen
AU560584B2 (en) * 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
DE3410437A1 (de) * 1984-03-22 1985-09-26 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von proteinen
ATE64956T1 (de) * 1984-06-14 1991-07-15 Ciba Geigy Ag Verfahren zur herstellung von thrombininhibitoren.
WO1986000337A1 (fr) * 1984-06-19 1986-01-16 Transgene S.A. DERIVES DE L'alpha1-ANTITRYPSINE HUMAINE ET PROCEDE POUR LEUR PREPARATION
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
ATE81673T1 (de) * 1984-08-16 1992-11-15 Bio Technology General Corp Verfahren zur beseitigung von nendaminos|ureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.
DE3523701A1 (de) * 1985-07-03 1987-01-08 Bayer Ag Verfahren zur herstellung von proteinen und polypeptiden
GB2188933A (en) * 1986-04-10 1987-10-14 Bayer Ag Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby

Also Published As

Publication number Publication date
DK151687D0 (da) 1987-03-25
FI871288A (sv) 1987-09-27
KR890002401A (ko) 1989-04-10
GB8607523D0 (en) 1986-04-30
FI94876B (sv) 1995-07-31
DE3751324D1 (de) 1995-07-06
KR870009025A (ko) 1987-10-22
JPS637794A (ja) 1988-01-13
JP2537507B2 (ja) 1996-09-25
KR960007194B1 (ko) 1996-05-29
IL81964A0 (en) 1987-10-20
EP0238993B1 (de) 1995-05-31
ZA872181B (en) 1987-12-30
ATE123301T1 (de) 1995-06-15
IL81964A (en) 1993-07-08
ES2073390T3 (es) 1995-08-16
AU600475B2 (en) 1990-08-16
KR950000302B1 (ko) 1995-01-13
DK151687A (da) 1987-09-27
EP0238993A3 (en) 1989-03-22
CA1338309C (en) 1996-05-07
US4894436A (en) 1990-01-16
EP0238993A2 (de) 1987-09-30
CN87102412A (zh) 1987-10-07
GB2188322A (en) 1987-09-30
FI94876C (sv) 1995-11-10
AU6990187A (en) 1987-10-01
CN1018793B (zh) 1992-10-28

Similar Documents

Publication Publication Date Title
FI871288A0 (sv) Förfarande för framställning av aprotinin med rekombinant-DNA-teknik och vid förfarandet användbart DNA, expressionsplasmid och värdcell
DK198883D0 (da) Fremgangsmade til fremstilling af menneskevaevs-plasminogenaktivator, dna-sekvens der koder for denne aktivator, replicerbar udtrykkelsesvektor for dna-sekvensen og microorganisme eller cellekultur transformeret med udtrykkelsesvektoren
DE69418639D1 (de) Sulfonat- und Carbamatderivate von 3-aroyl-benzo(beta)Thiophenen
DK322188A (da) Fremgangsmaade til fremstilling af protein
PT98113A (pt) Processo para a preparacao de proteinas de fusao com uma fraccao de imunoglobulina
BR8301918A (pt) Proteina,sequencia de dna,veiculo de expressao replicavel,microorganismo ou cultura celular,plasmideo,composicao,cultura de celulas,utilizacao de tal proteina,processo de expressao,processo para producao de um veiculo de expressao e processo para preparacao de uma proteina uroquinase
DK427485D0 (da) Blodkoagulationshaemmende proteiner, fremgangsmaade til deres fremstilling samt deres anvendelse
DE3587549D1 (de) Ergänzungstestverfahren von proteine bindenden enzymen.
AU1402788A (en) Vascular anticoagulant proteins
DE69101634D1 (de) Rekombinant hergestellte blutfaktoren, verfahren zur exprimierung besagter blutfaktoren sowie in besagtem prozess verwendeter rekombinanter vaccina-virus.
EP1222255A4 (en) POLYPEPTIDE FRAGMENTS COMPRISING A C-TERMINAL PART OF HELICOBACTER CATALASE
IT8921789A0 (it) Reattivo per la ricerca e la determinazione della bilirubina nelle urine.
AU4312093A (en) Use of a hymenoptera venom for the manufacture of a medicament for treating dna virus infections
ES2110998T3 (es) Procedimiento para la determinacion de las trombopenias.
FI885025A (fi) Koagulationshaemmande protein pp4-x, dess framstaellning och anvaendning.
DE3790139D2 (en) Antiparatypical antibodies, their use for detecting and treating auto-immune diseases
AU4266289A (en) Antidote
ATE78513T1 (de) Immunoglobulin-a-rezeptor-protein (arp), sowie dessen klonierung und expression.
SE8402717L (sv) Hiss, i synnerhet handikapphiss

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed

Owner name: BAYER AKTIENGESELLSCHAFT