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FI69835C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-ndolyl-tertiaerbutylaminopropanolderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-ndolyl-tertiaerbutylaminopropanolderivat Download PDF

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Publication number
FI69835C
FI69835C FI782205A FI782205A FI69835C FI 69835 C FI69835 C FI 69835C FI 782205 A FI782205 A FI 782205A FI 782205 A FI782205 A FI 782205A FI 69835 C FI69835 C FI 69835C
Authority
FI
Finland
Prior art keywords
formula
indolyl
compound
prepared
process according
Prior art date
Application number
FI782205A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI782205A (fi
FI69835B (fi
Inventor
William E Kreighbaum
William T Comer
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI782205A publication Critical patent/FI782205A/fi
Application granted granted Critical
Publication of FI69835B publication Critical patent/FI69835B/fi
Publication of FI69835C publication Critical patent/FI69835C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI782205A 1977-07-13 1978-07-10 Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-ndolyl-tertiaerbutylaminopropanolderivat FI69835C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81513877A 1977-07-13 1977-07-13
US81513877 1977-07-13

Publications (3)

Publication Number Publication Date
FI782205A FI782205A (fi) 1979-01-14
FI69835B FI69835B (fi) 1985-12-31
FI69835C true FI69835C (fi) 1986-05-26

Family

ID=25216976

Family Applications (1)

Application Number Title Priority Date Filing Date
FI782205A FI69835C (fi) 1977-07-13 1978-07-10 Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-ndolyl-tertiaerbutylaminopropanolderivat

Country Status (30)

Country Link
JP (1) JPS5419972A (fr)
AR (1) AR225274A1 (fr)
AT (1) AT364821B (fr)
AU (1) AU525064B2 (fr)
BE (1) BE868943A (fr)
CA (1) CA1116598A (fr)
CH (1) CH642066A5 (fr)
CY (1) CY1274A (fr)
DE (1) DE2830884A1 (fr)
DK (1) DK156568C (fr)
ES (1) ES471674A1 (fr)
FI (1) FI69835C (fr)
FR (1) FR2397404A1 (fr)
GB (1) GB2001633B (fr)
GR (1) GR74488B (fr)
HK (1) HK1385A (fr)
HU (1) HU178992B (fr)
IE (1) IE47122B1 (fr)
IL (1) IL55115A (fr)
IT (1) IT1105091B (fr)
KE (1) KE3485A (fr)
LU (1) LU79966A1 (fr)
MY (1) MY8500946A (fr)
NL (1) NL189946C (fr)
NO (1) NO149311C (fr)
NZ (1) NZ187763A (fr)
SE (1) SE429339B (fr)
SG (1) SG82584G (fr)
YU (1) YU40528B (fr)
ZA (1) ZA783744B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463765A1 (fr) * 1979-08-17 1981-02-27 Clin Midy Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire
US4321398A (en) * 1981-05-07 1982-03-23 Mead Johnson & Company Thienyl and benzothienyl-tertiary butylaminophenoxypropanols
DE3119796A1 (de) * 1981-05-19 1982-12-23 Hoechst Ag, 6000 Frankfurt Substituierte tryptaminderivate von thienyloxpropanolaminen, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen sowie ihre verwendung
FR2523964B1 (fr) * 1982-03-23 1985-09-27 Sanofi Sa Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation
NZ208337A (en) * 1983-06-10 1988-10-28 Bristol Myers Co 2-(2-hydroxy-3-((2-(ar-hydroxy-1h-aminopropoxy-yl)ethyl benzonitriles and pharmaceutical compositions
FR2601008B1 (fr) * 1986-07-03 1990-03-30 Sanofi Sa Procede de synthese stereospecifique de derives de l'indole
CA2421594A1 (fr) 2000-11-10 2002-05-16 John Arnold Werner Agonistes du recepteur beta-3 d'oxindole 3-substitue
US6911463B2 (en) 2001-08-14 2005-06-28 Eli Lilly And Company 3-substituted oxindole β-3 agonists
DE60215028T2 (de) 2001-08-14 2007-03-15 Eli Lilly And Co., Indianapolis Indol derivate als beta-3-adrenerge agonisten zur behandlung von typ 2 diabetes
JP2005518357A (ja) 2001-11-20 2005-06-23 イーライ・リリー・アンド・カンパニー ベータ３アドレナリンアゴニスト
JP2005514366A (ja) 2001-11-20 2005-05-19 イーライ・リリー・アンド・カンパニー ３−置換オキシインドールβ３アゴニスト
EP1467733A1 (fr) 2002-01-11 2004-10-20 Eli Lilly And Company Derives d'ethanolamine a substitution de 2-oxo-benzimidazolyle, et leur utilisation comme beta3 agonistes
US8946284B2 (en) 2008-08-01 2015-02-03 Arca Biopharma, Inc. Methods and compositions involving (S)-bucindolol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1532210A (fr) * 1963-06-21 1968-07-12 Ici Ltd Composés hétérocycliques et leur procédé de préparation
CH495983A (de) * 1968-02-09 1970-09-15 Sandoz Ag Verfahren zur Herstellung von linksdrehendem 4-(2-Hydroxy-3-isopropylaminopropoxy)indol
US3371098A (en) * 1966-11-29 1968-02-27 Philips Corp 5- and 6-methoxy-3-(phenoxyethyl-aminoethyl)-indoles
US3946009A (en) * 1972-05-05 1976-03-23 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines

Also Published As

Publication number Publication date
AU3770478A (en) 1980-01-10
NL7807564A (nl) 1979-01-16
DK156568B (da) 1989-09-11
NO149311B (no) 1983-12-19
NO782407L (no) 1979-01-16
GB2001633B (en) 1982-03-24
FI782205A (fi) 1979-01-14
JPS5419972A (en) 1979-02-15
FR2397404A1 (fr) 1979-02-09
GB2001633A (en) 1979-02-07
IE47122B1 (en) 1983-12-28
NZ187763A (en) 1984-07-31
FR2397404B1 (fr) 1982-06-11
ES471674A1 (es) 1979-10-01
IT7850228A0 (it) 1978-07-10
AT364821B (de) 1981-11-25
JPS6340784B2 (fr) 1988-08-12
LU79966A1 (fr) 1979-04-09
CY1274A (en) 1985-03-08
MY8500946A (en) 1985-12-31
IT1105091B (it) 1985-10-28
CA1116598A (fr) 1982-01-19
YU40528B (en) 1986-02-28
KE3485A (en) 1985-01-25
YU161178A (en) 1983-02-28
HK1385A (en) 1985-01-11
ATA508978A (de) 1981-04-15
DK313878A (da) 1979-01-14
GR74488B (fr) 1984-06-28
HU178992B (en) 1982-07-28
NL189946B (nl) 1993-04-16
SG82584G (en) 1985-09-13
IL55115A0 (en) 1978-09-29
SE429339B (sv) 1983-08-29
DK156568C (da) 1990-02-05
DE2830884C2 (fr) 1990-01-11
AR225274A1 (es) 1982-03-15
ZA783744B (en) 1979-07-25
AU525064B2 (en) 1982-10-21
CH642066A5 (de) 1984-03-30
IL55115A (en) 1981-09-13
DE2830884A1 (de) 1979-02-01
FI69835B (fi) 1985-12-31
BE868943A (fr) 1979-01-12
NL189946C (nl) 1993-09-16
IE781400L (en) 1979-01-13
SE7807700L (sv) 1979-01-14
NO149311C (no) 1984-03-28

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MA Patent expired
MA Patent expired

Owner name: BRISTOL-MYERS CO