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FI101703B1 - Menetelmä uusien antiateroskleroottisina aineina käytettävien 2,6-dialkyyli-4-silyyli-fenolien valmistamiseksi - Google Patents

Menetelmä uusien antiateroskleroottisina aineina käytettävien 2,6-dialkyyli-4-silyyli-fenolien valmistamiseksi

Info

Publication number
FI101703B1
FI101703B1 FI913252A FI913252A FI101703B1 FI 101703 B1 FI101703 B1 FI 101703B1 FI 913252 A FI913252 A FI 913252A FI 913252 A FI913252 A FI 913252A FI 101703 B1 FI101703 B1 FI 101703B1
Authority
FI
Finland
Prior art keywords
silyl
dialkyl
preparation
new
atherosclerotic agents
Prior art date
Application number
FI913252A
Other languages
English (en)
Swedish (sv)
Other versions
FI913252A0 (fi
FI913252A (fi
FI101703B (fi
Inventor
Roger Alan Parker
Simon Jen Tan Mao
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI913252A0 publication Critical patent/FI913252A0/fi
Publication of FI913252A publication Critical patent/FI913252A/fi
Application granted granted Critical
Publication of FI101703B1 publication Critical patent/FI101703B1/fi
Publication of FI101703B publication Critical patent/FI101703B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/32—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing two or more of boron, silicon, phosphorus, selenium, tellurium or a metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
FI913252A 1990-07-05 1991-07-04 Menetelmä uusien antiateroskleroottisina aineina käytettävien 2,6-dial kyyli-4-silyyli-fenolien valmistamiseksi FI101703B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/548,052 US5155250A (en) 1990-07-05 1990-07-05 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
US54805290 1990-07-05

Publications (4)

Publication Number Publication Date
FI913252A0 FI913252A0 (fi) 1991-07-04
FI913252A FI913252A (fi) 1992-01-06
FI101703B1 true FI101703B1 (fi) 1998-08-14
FI101703B FI101703B (fi) 1998-08-14

Family

ID=24187205

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913252A FI101703B (fi) 1990-07-05 1991-07-04 Menetelmä uusien antiateroskleroottisina aineina käytettävien 2,6-dial kyyli-4-silyyli-fenolien valmistamiseksi

Country Status (20)

Country Link
US (2) US5155250A (fi)
EP (1) EP0464852B1 (fi)
JP (1) JP2963556B2 (fi)
KR (1) KR0186005B1 (fi)
CN (1) CN1029615C (fi)
AT (1) ATE135705T1 (fi)
AU (1) AU639576B2 (fi)
CA (1) CA2046051C (fi)
DE (1) DE69118028T2 (fi)
DK (1) DK0464852T3 (fi)
ES (1) ES2087180T3 (fi)
FI (1) FI101703B (fi)
GR (1) GR3019393T3 (fi)
HU (1) HU211074B (fi)
IE (1) IE912340A1 (fi)
IL (1) IL98712A (fi)
NO (1) NO180490C (fi)
NZ (1) NZ238808A (fi)
PT (1) PT98220B (fi)
ZA (1) ZA915074B (fi)

Families Citing this family (42)

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NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
FR2707989B1 (fr) * 1993-07-22 1995-10-13 Pf Medicament Nouveaux dérivés de benzylamines silylées, leurs sels, leurs procédés de fabrication et les compositions pharmaceutiques les renfermant.
HU220761B1 (hu) * 1993-12-10 2002-05-28 Merrell Pharmaceuticals Inc. 2,6-Dialkil-4-szilil-helyettesített fenolok alkalmazása szérum koleszterinszint csökkentésére használható gyógyszerkészítmények előállítására
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
EP0734398B1 (en) * 1993-12-15 2002-02-27 Smithkline Beecham Corporation Compounds and methods
FR2722198B1 (fr) * 1994-07-08 1996-10-04 Pf Medicament 1derives de silylmethyl-anilines, le2fabrication, et leur utilisation co
IL126744A0 (en) * 1996-04-30 1999-08-17 Hoechst Marion Roussel Inc Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-Di-alkyl-4-silyl-phenols
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
JP2000511225A (ja) * 1996-05-20 2000-08-29 スミスクライン・ビーチャム・コーポレイション アリール―含有分子の固相有機合成のためのシリルリンカー
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
CN100453530C (zh) * 1997-05-14 2009-01-21 阿特罗吉尼克斯公司 抑制vcam-1表达的化合物及其药物组合物
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
PT998477E (pt) * 1997-06-24 2003-07-31 Aventis Pharma Inc Fenois e tiofenois alquil-4-silil-heterociclicos como agentes antioxidantes
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
AU7588498A (en) * 1997-06-25 1999-01-04 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-{ (dimethyl-4-methoxyphenylsilyl) -methyloxy}phenol and 2,6-di-t-butyl-4-{ (dimethyl-2-methoxy-phenylsilyl) -methyloxy}phenol
CA2294247C (en) * 1997-07-01 2004-10-26 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
ATE326014T1 (de) * 1998-11-09 2006-06-15 Atherogenics Inc Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasma
JP4408982B2 (ja) * 1999-03-31 2010-02-03 東レ・ダウコーニング株式会社 フェノール基含有有機ケイ素化合物およびその製造方法
CA2428753C (en) 2000-11-17 2013-05-21 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
EP1446113A4 (en) * 2001-10-25 2006-12-06 Atherogenics Inc COMPOUNDS AND METHOD FOR THE TREATMENT OF TRANSPLANT DISCHARGE
JP2006506314A (ja) * 2001-11-09 2006-02-23 アセロジエニクス・インコーポレイテツド 心血管疾患の逆転及び予防方法
US7094801B2 (en) * 2001-12-19 2006-08-22 Atherogenics, Inc. Chalcone derivatives and their use to treat diseases
CA2492433A1 (en) * 2002-07-12 2004-01-22 Artherogenics, Inc. Organic amine salts of poorly soluble probucol esters and ethers
WO2004024094A2 (en) * 2002-09-13 2004-03-25 Samford University Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
AU2003303239A1 (en) * 2002-12-19 2004-07-14 Atherogenics, Inc. Process of making chalcone derivatives
CN101391972A (zh) * 2003-01-13 2009-03-25 阿特罗吉尼克斯公司 制备普罗布考及其衍生物的酯和醚的方法
US7173129B2 (en) * 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005037250A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self emulsifying drug delivery systems for hydrophobic therapeutic compounds
JP2007509054A (ja) * 2003-10-17 2007-04-12 アミリン・ファーマシューティカルズ，インコーポレイテッド 血管健康を促進するシリルフェノール
WO2005037251A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self-emulsifying drug delivery systems for hydrophobic therapeutic compounds
WO2005102323A2 (en) 2004-04-20 2005-11-03 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US20060063828A1 (en) * 2004-06-28 2006-03-23 Weingarten M D 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
EP1768660A4 (en) * 2004-07-01 2009-05-13 Atherogenics Inc COMPOUNDS AND METHODS FOR TREATING DIABETIC VASCULAR DISEASES
BRPI0809423A2 (pt) * 2007-03-26 2014-09-09 Salutria Pharmaceuticals Llc Usos e composições de derivados de probucol para o tratamento de diabetes
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes
DE102007015948A1 (de) * 2007-04-03 2008-10-09 Bayer Materialscience Ag Modifizierte Polycarbonate, Polyestercarbonate und Polyester mit verbessertem Dehnverhalten und Flammwidrigkeit
US20090254425A1 (en) * 2008-04-02 2009-10-08 Evan Horowitz Wiki-type collective intelligence mechanism for implementing a url redirect

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328450A (en) * 1963-01-09 1967-06-27 Dow Corning Silylalkyl phenols
US3506674A (en) * 1967-07-03 1970-04-14 Gen Electric Certain pyridyl thio ether silanes
GB1232394A (fi) * 1967-08-17 1971-05-19
US3853776A (en) * 1972-09-29 1974-12-10 Monsanto Co Low pour point fluids and blends containing same
US3801617A (en) * 1973-07-24 1974-04-02 Nasa Thiophenyl ether disiloxanes and trisiloxanes useful as lubricant fluids
DE2933206A1 (de) * 1978-08-18 1980-02-28 Ciba Geigy Ag Phenolhaltige silane und deren verwendung als schmiermittelzusaetze
US4624909A (en) * 1984-04-27 1986-11-25 Nec Corporation Silicon-containing novolak resin and resist material and pattern forming method using same
JPS61263988A (ja) * 1985-05-16 1986-11-21 Shionogi & Co Ltd シリル置換エ−テル類および殺虫・殺ダニ剤
US4636573A (en) * 1985-09-09 1987-01-13 Pastor Stephen D Hindered silicon ester stabilizers
DE3604781A1 (de) * 1986-02-13 1987-08-27 Schering Ag Neue silane, verfahren zu ihrer herstellung und diese verbindungen enthaltende einsektizide mittel
US4804653A (en) * 1986-05-02 1989-02-14 Uniroyal Chemical Company, Inc. Thiomethyl-substituted organosilane compounds and their use as pesticides
DE3638073A1 (de) * 1986-11-07 1988-05-11 Swf Auto Electric Gmbh Vorrichtung, insbesondere hubwischeranlage fuer kraftfahrzeuge
US4783495A (en) * 1987-11-20 1988-11-08 Ciba-Geigy Corporation (Hydroxyphenyl) silane stabilizers
US5138012A (en) * 1988-07-29 1992-08-11 General Electric Company Silicone release coating compositions
DE4031001A1 (de) * 1990-10-01 1992-04-02 Hoechst Ag Verfahren zur herstellung von 4-ethoxyphenyl-3-arylpropyl-(dimethyl)silanen

Also Published As

Publication number Publication date
EP0464852A1 (en) 1992-01-08
CA2046051A1 (en) 1992-01-06
NZ238808A (en) 1994-02-25
US5532400A (en) 1996-07-02
HU211074B (en) 1995-10-30
ZA915074B (en) 1992-04-29
CA2046051C (en) 2001-06-05
JP2963556B2 (ja) 1999-10-18
IL98712A (en) 1995-11-27
CN1057843A (zh) 1992-01-15
DK0464852T3 (da) 1996-04-15
AU639576B2 (en) 1993-07-29
DE69118028T2 (de) 1996-11-28
DE69118028D1 (de) 1996-04-25
AU8011691A (en) 1992-01-09
NO180490C (no) 1997-04-30
ATE135705T1 (de) 1996-04-15
NO912630L (no) 1992-01-06
PT98220A (pt) 1992-05-29
FI913252A0 (fi) 1991-07-04
FI913252A (fi) 1992-01-06
CN1029615C (zh) 1995-08-30
KR0186005B1 (ko) 1999-05-15
HU912272D0 (en) 1991-12-30
HUT58749A (en) 1992-03-30
GR3019393T3 (en) 1996-06-30
EP0464852B1 (en) 1996-03-20
JPH04230393A (ja) 1992-08-19
IE912340A1 (en) 1992-01-15
NO180490B (no) 1997-01-20
NO912630D0 (no) 1991-07-04
US5155250A (en) 1992-10-13
PT98220B (pt) 1998-12-31
KR920002617A (ko) 1992-02-28
IL98712A0 (en) 1992-07-15
FI101703B (fi) 1998-08-14
ES2087180T3 (es) 1996-07-16

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Legal Events

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Owner name: AVENTIS INC.

Free format text: AVENTIS INC.