FI104251B1 - Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi - Google Patents

Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi

Info

Publication number: FI104251B1
Authority: FI; Finland
Prior art keywords: inflammatory bowel; preparation; treatment; compounds useful; bowel diseases
Prior art date: 1989-12-21

Application number

FI906273A

Other languages

English (en)

Swedish (sv)

Other versions

FI104251B (fi

FI906273A0 (fi

FI906273A (fi

Inventor

Jaswant Singh Gidda

Jill Ann Panetta

Michael Leroy Phillips

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-19

Publication date

1999-12-15

1990-12-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1990-12-19 Publication of FI906273A0 publication Critical patent/FI906273A0/fi

1991-06-22 Publication of FI906273A publication Critical patent/FI906273A/fi

1999-12-15 Application granted granted Critical

1999-12-15 Publication of FI104251B publication Critical patent/FI104251B/fi

1999-12-15 Publication of FI104251B1 publication Critical patent/FI104251B1/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Surgical Instruments (AREA)
Nonmetallic Welding Materials (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Eye Examination Apparatus (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FI906273A 1989-12-21 1990-12-19 Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi FI104251B1 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45420389A	1989-12-21	1989-12-21
US45420389		1989-12-21

Publications (4)

Publication Number	Publication Date
FI906273A0 FI906273A0 (fi)	1990-12-19
FI906273A FI906273A (fi)	1991-06-22
FI104251B FI104251B (fi)	1999-12-15
FI104251B1 true FI104251B1 (fi)	1999-12-15

Family

ID=23803709

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FI906273A FI104251B1 (fi)	1989-12-21	1990-12-19	Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi
FI991698A FI19991698A (fi)	1989-12-21	1999-08-10	Menetelmä selektiivisesti eristää, oleellisesti puhtaassa enantiomeerisessä muodossa, raseemisten bentsyylisubstituoitujen rodaniinijohdannaisten enantiomeerejä

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
FI991698A FI19991698A (fi)	1989-12-21	1999-08-10	Menetelmä selektiivisesti eristää, oleellisesti puhtaassa enantiomeerisessä muodossa, raseemisten bentsyylisubstituoitujen rodaniinijohdannaisten enantiomeerejä

Country Status (22)

Country	Link
EP (1)	EP0434394B1 (fi)
JP (1)	JP3036853B2 (fi)
KR (1)	KR0176243B1 (fi)
CN (1)	CN1029846C (fi)
AT (1)	ATE169294T1 (fi)
AU (1)	AU639734B2 (fi)
CA (1)	CA2032330C (fi)
CY (1)	CY2100B1 (fi)
DE (1)	DE69032537T2 (fi)
DK (1)	DK0434394T3 (fi)
ES (1)	ES2121748T3 (fi)
FI (2)	FI104251B1 (fi)
HU (1)	HU216732B (fi)
IE (1)	IE904633A1 (fi)
IL (3)	IL108962A (fi)
MX (1)	MX23803A (fi)
NO (1)	NO300458B1 (fi)
NZ (1)	NZ236472A (fi)
PT (1)	PT96198B (fi)
RU (2)	RU2036915C1 (fi)
YU (1)	YU240690A (fi)
ZA (1)	ZA9010041B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU87339A1 (fr) *	1988-09-20	1990-04-06	Oreal	Nouveaux derives de benzylidene-cyclanones,leur procede de preparation,leur utilisation en tant qu'agents anti-oxydants et comme filtres solaires,compositions cosmetiques et pharmaceutiques les contenant
US5143928A (en) *	1990-03-27	1992-09-01	Warner-Lambert Company	3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
CZ181493A3 (en) *	1992-09-10	1994-03-16	Lilly Co Eli	The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease
ES2089736T3 (es) *	1992-10-28	1996-10-01	Shionogi & Co	Derivados de bencilideno.
US6251928B1 (en) *	1994-03-16	2001-06-26	Eli Lilly And Company	Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5563277A (en) *	1994-12-21	1996-10-08	Eli Lilly And Company	Process for preparing benzyl-substituted rhodanine derivatives
PT761656E (pt) *	1995-09-07	2001-04-30	Lilly Co Eli	Forma cristalina de tazofelona((+,-)-5-((3,5-bis(1,1-dimetiletil)-4-hidroxifenil)metil)-4-tiazolidinona)
DE69608512T2 (de) *	1995-09-07	2001-01-25	Eli Lilly And Co., Indianapolis	Verfahren zur Herstellung von benzylsubstituierten Rhodaninederivaten
EP0779282A1 (en) *	1995-12-14	1997-06-18	Eli Lilly And Company	Thiomorpholinone compounds for treating multiple sclerosis
US5981523A (en) *	1996-02-05	1999-11-09	Eli Lilly And Company	Compounds and methods for treating multiple sclerosis
US6063799A (en) *	1996-09-03	2000-05-16	Eli Lilly And Company	Alternate crystal form of Tazofelone
US6005142A (en)	1996-09-03	1999-12-21	Eli Lilly And Company	Process for preparing benzyl-substituted rhodanine derivatives
WO2000018746A1 (en) *	1998-09-30	2000-04-06	Roche Diagnostics Gmbh	Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders
US6673816B1 (en)	1998-09-30	2004-01-06	Angelika Esswein	Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
WO2000018748A1 (en) *	1998-09-30	2000-04-06	Roche Diagnostics Gmbh	Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
WO2004028480A2 (en) *	2002-09-30	2004-04-08	The Regents Of The University Of California	Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
US7235573B2 (en)	2002-09-30	2007-06-26	The Regents Of The University Of California	Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
AU2002953533A0 (en)	2002-12-24	2003-01-16	Arthron Limited	Fc receptor modulating compounds and compositions
JP5778755B2 (ja) *	2010-04-15	2015-09-16	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	ヒドロキノンの製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT83152B (pt) *	1985-08-09	1989-03-30	Lilly Co Eli	Processo para a preparacao de compostos di-t-butilfenoicos
IE62214B1 (en) *	1988-05-25	1995-01-11	Warner Lambert Co	Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents
ES2088965T3 (es) *	1989-04-07	1996-10-01	Lilly Co Eli	Derivados de rodanina aril-sustituidos.

1990
- 1990-12-13 ZA ZA9010041A patent/ZA9010041B/xx unknown
- 1990-12-13 IL IL10896290A patent/IL108962A/en not_active IP Right Cessation
- 1990-12-13 IL IL9665490A patent/IL96654A/en not_active IP Right Cessation
- 1990-12-14 CA CA002032330A patent/CA2032330C/en not_active Expired - Fee Related
- 1990-12-14 PT PT96198A patent/PT96198B/pt active IP Right Grant
- 1990-12-14 NZ NZ236472A patent/NZ236472A/xx unknown
- 1990-12-19 DK DK90313923T patent/DK0434394T3/da active
- 1990-12-19 FI FI906273A patent/FI104251B1/fi not_active IP Right Cessation
- 1990-12-19 NO NO905478A patent/NO300458B1/no not_active IP Right Cessation
- 1990-12-19 MX MX2380390A patent/MX23803A/es unknown
- 1990-12-19 AU AU68266/90A patent/AU639734B2/en not_active Ceased
- 1990-12-19 EP EP90313923A patent/EP0434394B1/en not_active Expired - Lifetime
- 1990-12-19 AT AT90313923T patent/ATE169294T1/de not_active IP Right Cessation
- 1990-12-19 KR KR1019900021001A patent/KR0176243B1/ko not_active IP Right Cessation
- 1990-12-19 ES ES90313923T patent/ES2121748T3/es not_active Expired - Lifetime
- 1990-12-19 DE DE69032537T patent/DE69032537T2/de not_active Expired - Fee Related
- 1990-12-20 JP JP2413313A patent/JP3036853B2/ja not_active Expired - Fee Related
- 1990-12-20 IE IE463390A patent/IE904633A1/en not_active Application Discontinuation
- 1990-12-20 YU YU240690A patent/YU240690A/sh unknown
- 1990-12-20 HU HU908368A patent/HU216732B/hu not_active IP Right Cessation
- 1990-12-20 RU SU904894177A patent/RU2036915C1/ru active
- 1990-12-20 CN CN90109846A patent/CN1029846C/zh not_active Expired - Fee Related
1991
- 1991-12-24 RU SU915010352A patent/RU2050355C1/ru active
1994
- 1994-03-14 IL IL10896294A patent/IL108962A0/xx unknown
1998
- 1998-09-07 CY CY9800024A patent/CY2100B1/xx unknown
1999
- 1999-08-10 FI FI991698A patent/FI19991698A/fi unknown

Also Published As

Publication number	Publication date
RU2050355C1 (ru)	1995-12-20
ATE169294T1 (de)	1998-08-15
PT96198B (pt)	1998-05-29
FI104251B (fi)	1999-12-15
JPH04279573A (ja)	1992-10-05
NZ236472A (en)	1993-03-26
FI906273A0 (fi)	1990-12-19
IL108962A0 (en)	1994-06-24
NO905478D0 (no)	1990-12-19
HU216732B (hu)	1999-08-30
NO300458B1 (no)	1997-06-02
CA2032330A1 (en)	1991-06-22
IL108962A (en)	1996-12-05
KR910011812A (ko)	1991-08-07
NO905478L (no)	1991-06-24
DE69032537T2 (de)	1999-01-21
EP0434394B1 (en)	1998-08-05
CY2100B1 (en)	2002-04-05
DK0434394T3 (da)	1998-12-14
CN1029846C (zh)	1995-09-27
KR0176243B1 (ko)	1999-03-20
FI19991698A (fi)	1999-08-10
DE69032537D1 (de)	1998-09-10
AU639734B2 (en)	1993-08-05
ES2121748T3 (es)	1998-12-16
AU6826690A (en)	1991-06-27
IL96654A (en)	1995-06-29
HUT59915A (en)	1992-07-28
EP0434394A3 (en)	1992-01-08
FI906273A (fi)	1991-06-22
CN1052668A (zh)	1991-07-03
MX23803A (es)	1994-02-28
JP3036853B2 (ja)	2000-04-24
PT96198A (pt)	1991-09-30
ZA9010041B (en)	1992-08-26
RU2036915C1 (ru)	1995-06-09
HU908368D0 (en)	1991-07-29
YU240690A (sh)	1992-12-21
EP0434394A2 (en)	1991-06-26
IE904633A1 (en)	1991-07-17
CA2032330C (en)	2001-05-08

Publication	Publication Date	Title
FI104251B1 (fi)	1999-12-15	Menetelmä tulehduksellisten suolistosairauksien hoitoon käyttökelpoisten yhdisteiden valmistamiseksi
NO301883B1 (no)	1997-12-22	Analogifremgangsmåte ved fremstilling av heterocykliske forbindelser
NO874350D0 (no)	1987-10-19	Fremgangsmaate for fremstilling av antibakterielle forbindelser.
HUT45247A (en)	1988-06-28	Process for producing thiazolidinediones with hypolycaemic effect and pharmaceutical compositions comprising the same
DE68913860D1 (de)	1994-04-21	Pressform und Formgebungsverfahren zum Herstellen von optischen Teilen.
HUT49113A (en)	1989-08-28	Process for producing 2-/2-hydroxy-3-phenoxy-propyl-amino/-ethyl-phenoxy-methyl-amido derivatives and pharmaceutical compositions containing them as active components
NO302414B1 (no)	1998-03-02	Analogifremgangsmåte for fremstilling av heterocykliske forbindelser
PL300327A1 (en)	1994-03-21	Substituted cycolohexane derivatives, method of obtaining them and application of these compounds in treating diseases
HUT35680A (en)	1985-07-29	Process for preparing purine derivatives
DE3775496D1 (de)	1992-02-06	Benzhydryloxyaethyl-piperidine-derivate, verfahren zur herstellung und pharmazeutische zusammenstellungen, die diese enthalten.
DE69527802D1 (de)	2002-09-19	Verfahren zur herstellung von benzyl-substituierten rhodanin derivaten
FR2623501B1 (fr)	1990-03-16	Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FI873843A0 (fi)	1987-09-04	Menetelmä uusien terapeuttisesti käyttökelpoisten 4-C-hydroksi-2-r-(substituoitu)kromaani-4-etikkahappojohdannaisten valmistamiseksi
CS53688A2 (en)	1989-04-14	Method of new substituted 3-phenyl-7h-thiazolo/3,2-b//1,2,4/triazine -7-ons production
HUT57749A (en)	1991-12-30	Process for producing pharmaceutical compositions suitable for treating pathological conditions concerning cerebral blood insufficiency and one special active ingredient
AU7196987A (en)	1988-01-07	1,4-dihydropyridine derivatives, process for their preparation and medicaments containing these compounds
NO834759L (no)	1984-06-25	Fremgangsmaate ved fremstilling av nye 6alfa-methylprednisolonderivater

Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: ELI LILLY AND COMPANY