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ES2121748T3 - Compuestos para el tratamiento de la enfermedad inflamatoria del intestino. - Google Patents

Compuestos para el tratamiento de la enfermedad inflamatoria del intestino.

Info

Publication number
ES2121748T3
ES2121748T3 ES90313923T ES90313923T ES2121748T3 ES 2121748 T3 ES2121748 T3 ES 2121748T3 ES 90313923 T ES90313923 T ES 90313923T ES 90313923 T ES90313923 T ES 90313923T ES 2121748 T3 ES2121748 T3 ES 2121748T3
Authority
ES
Spain
Prior art keywords
benzyl
intestine
compounds
treatment
inflammatory disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90313923T
Other languages
English (en)
Inventor
Jaswant Singh Gidda
Jill Ann Panetta
Michael Leroy Phillips
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2121748T3 publication Critical patent/ES2121748T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Surgical Instruments (AREA)
  • Nonmetallic Welding Materials (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Eye Examination Apparatus (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REVELA UN METODO PARA TRATAR ENFERMEDADES DE INTESTINO INFLAMADO EN MAMIFEROS UTILIZANDO CIERTOS DERIVADOS DE RODAMINA SUSTITUIDA DE BENCILO. TAMBIEN SE REVELAN NUEVOS DERIVADOS DE RODANINA SUSTITUIDA DE BENCILO, UN PROCESO PARA SU PRODUCCION Y SUS COMPOSICIONES FARMACEUTICAS. ADEMAS SE REVELA UN NUEVO PROCESO PARA AISLAR SELECTIVAMENTE EN FORMA ENANTIOMERICA SUSTANCIALMENTE PARA LOS ENANTIOMEROS DE CIERTOS DERIVADOS RACEMICOS DE RODAMINA SUSTITUIDA DE BENCILO.
ES90313923T 1989-12-21 1990-12-19 Compuestos para el tratamiento de la enfermedad inflamatoria del intestino. Expired - Lifetime ES2121748T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45420389A 1989-12-21 1989-12-21

Publications (1)

Publication Number Publication Date
ES2121748T3 true ES2121748T3 (es) 1998-12-16

Family

ID=23803709

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90313923T Expired - Lifetime ES2121748T3 (es) 1989-12-21 1990-12-19 Compuestos para el tratamiento de la enfermedad inflamatoria del intestino.

Country Status (22)

Country Link
EP (1) EP0434394B1 (es)
JP (1) JP3036853B2 (es)
KR (1) KR0176243B1 (es)
CN (1) CN1029846C (es)
AT (1) ATE169294T1 (es)
AU (1) AU639734B2 (es)
CA (1) CA2032330C (es)
CY (1) CY2100B1 (es)
DE (1) DE69032537T2 (es)
DK (1) DK0434394T3 (es)
ES (1) ES2121748T3 (es)
FI (2) FI104251B1 (es)
HU (1) HU216732B (es)
IE (1) IE904633A1 (es)
IL (3) IL108962A (es)
MX (1) MX23803A (es)
NO (1) NO300458B1 (es)
NZ (1) NZ236472A (es)
PT (1) PT96198B (es)
RU (2) RU2036915C1 (es)
YU (1) YU240690A (es)
ZA (1) ZA9010041B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87339A1 (fr) * 1988-09-20 1990-04-06 Oreal Nouveaux derives de benzylidene-cyclanones,leur procede de preparation,leur utilisation en tant qu'agents anti-oxydants et comme filtres solaires,compositions cosmetiques et pharmaceutiques les contenant
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
CZ181493A3 (en) * 1992-09-10 1994-03-16 Lilly Co Eli The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease
ES2089736T3 (es) * 1992-10-28 1996-10-01 Shionogi & Co Derivados de bencilideno.
US6251928B1 (en) * 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5563277A (en) * 1994-12-21 1996-10-08 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
PT761656E (pt) * 1995-09-07 2001-04-30 Lilly Co Eli Forma cristalina de tazofelona((+,-)-5-((3,5-bis(1,1-dimetiletil)-4-hidroxifenil)metil)-4-tiazolidinona)
DE69608512T2 (de) * 1995-09-07 2001-01-25 Eli Lilly And Co., Indianapolis Verfahren zur Herstellung von benzylsubstituierten Rhodaninederivaten
EP0779282A1 (en) * 1995-12-14 1997-06-18 Eli Lilly And Company Thiomorpholinone compounds for treating multiple sclerosis
US5981523A (en) * 1996-02-05 1999-11-09 Eli Lilly And Company Compounds and methods for treating multiple sclerosis
US6063799A (en) * 1996-09-03 2000-05-16 Eli Lilly And Company Alternate crystal form of Tazofelone
US6005142A (en) 1996-09-03 1999-12-21 Eli Lilly And Company Process for preparing benzyl-substituted rhodanine derivatives
WO2000018746A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders
US6673816B1 (en) 1998-09-30 2004-01-06 Angelika Esswein Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders
WO2000018748A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
WO2004028480A2 (en) * 2002-09-30 2004-04-08 The Regents Of The University Of California Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
US7235573B2 (en) 2002-09-30 2007-06-26 The Regents Of The University Of California Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
AU2002953533A0 (en) 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
JP5778755B2 (ja) * 2010-04-15 2015-09-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ヒドロキノンの製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83152B (pt) * 1985-08-09 1989-03-30 Lilly Co Eli Processo para a preparacao de compostos di-t-butilfenoicos
IE62214B1 (en) * 1988-05-25 1995-01-11 Warner Lambert Co Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents
ES2088965T3 (es) * 1989-04-07 1996-10-01 Lilly Co Eli Derivados de rodanina aril-sustituidos.

Also Published As

Publication number Publication date
RU2050355C1 (ru) 1995-12-20
ATE169294T1 (de) 1998-08-15
PT96198B (pt) 1998-05-29
FI104251B (fi) 1999-12-15
JPH04279573A (ja) 1992-10-05
NZ236472A (en) 1993-03-26
FI906273A0 (fi) 1990-12-19
IL108962A0 (en) 1994-06-24
NO905478D0 (no) 1990-12-19
HU216732B (hu) 1999-08-30
NO300458B1 (no) 1997-06-02
CA2032330A1 (en) 1991-06-22
IL108962A (en) 1996-12-05
KR910011812A (ko) 1991-08-07
NO905478L (no) 1991-06-24
DE69032537T2 (de) 1999-01-21
EP0434394B1 (en) 1998-08-05
CY2100B1 (en) 2002-04-05
DK0434394T3 (da) 1998-12-14
CN1029846C (zh) 1995-09-27
KR0176243B1 (ko) 1999-03-20
FI104251B1 (fi) 1999-12-15
FI19991698A (fi) 1999-08-10
DE69032537D1 (de) 1998-09-10
AU639734B2 (en) 1993-08-05
AU6826690A (en) 1991-06-27
IL96654A (en) 1995-06-29
HUT59915A (en) 1992-07-28
EP0434394A3 (en) 1992-01-08
FI906273A (fi) 1991-06-22
CN1052668A (zh) 1991-07-03
MX23803A (es) 1994-02-28
JP3036853B2 (ja) 2000-04-24
PT96198A (pt) 1991-09-30
ZA9010041B (en) 1992-08-26
RU2036915C1 (ru) 1995-06-09
HU908368D0 (en) 1991-07-29
YU240690A (sh) 1992-12-21
EP0434394A2 (en) 1991-06-26
IE904633A1 (en) 1991-07-17
CA2032330C (en) 2001-05-08

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