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ES8802028A1 - Procedimiento para preparar dihidropiridinas. - Google Patents

Procedimiento para preparar dihidropiridinas.

Info

Publication number
ES8802028A1
ES8802028A1 ES551845A ES551845A ES8802028A1 ES 8802028 A1 ES8802028 A1 ES 8802028A1 ES 551845 A ES551845 A ES 551845A ES 551845 A ES551845 A ES 551845A ES 8802028 A1 ES8802028 A1 ES 8802028A1
Authority
ES
Spain
Prior art keywords
alkyl
bears
phenylene
dihydropyridine
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551845A
Other languages
English (en)
Other versions
ES551845A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES8802028A1 publication Critical patent/ES8802028A1/es
Publication of ES551845A0 publication Critical patent/ES551845A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DIHIDROPIRIDINAS, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN EPOXIDO DE FORMULA GENERAL (II), EN LA QUE R1 ES ALQUILO O ALCOXIALQUILO/ R2 Y R3, QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN CADA UNO DE ELLOS UN GRUPO ACIDO DE HASTA 6 ATOMOS DE CARBONO; R4 ES ACIDO O HIDROXIALQUILO; EL ANILLO BENCENO A LLEVA UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE HALOGENO, CIANO O NITRO; Y AR ES FENILENO, NAFTILENO O TETRAHIDRONAFTILENO; X ES OXIGENO O NH; E Y ES ALQUILENO DE CADENA RECTA O RAMIFICADA, CON UNA AMINA DE FORMULA GENERAL (III). DE APLICACION EN MEDICINA POR SUS PROPIEDADES ANTIHIPERTENSIVAS.
ES551845A 1985-02-11 1986-02-11 Procedimiento para preparar dihidropiridinas. Expired ES8802028A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858503426A GB8503426D0 (en) 1985-02-11 1985-02-11 Pyridine derivatives

Publications (2)

Publication Number Publication Date
ES8802028A1 true ES8802028A1 (es) 1988-03-16
ES551845A0 ES551845A0 (es) 1988-03-16

Family

ID=10574271

Family Applications (1)

Application Number Title Priority Date Filing Date
ES551845A Expired ES8802028A1 (es) 1985-02-11 1986-02-11 Procedimiento para preparar dihidropiridinas.

Country Status (12)

Country Link
EP (1) EP0194046A1 (es)
JP (1) JPS61233668A (es)
AU (1) AU5326186A (es)
DK (1) DK65986A (es)
ES (1) ES8802028A1 (es)
FI (1) FI860620A (es)
GB (1) GB8503426D0 (es)
GR (1) GR860368B (es)
HU (1) HUT40413A (es)
NO (1) NO860464L (es)
PT (1) PT82007B (es)
ZA (1) ZA86815B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994476A (en) * 1984-10-31 1991-02-19 Bristol-Myers Company Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties
IL77843A (en) * 1985-02-11 1989-07-31 Syntex Inc Dihydropyridine derivatives,process and novel intermediates for their preparation and pharmaceutical compositions containing them
EP0254682A1 (de) * 1986-07-22 1988-01-27 Ciba-Geigy Ag Neue Phenoxyaliphatylphenylenoxyalkylester und -amide
CA2069877A1 (en) * 1990-10-02 1992-04-03 Michio Nakanishi Ethynylphenyl derivative substituted by pyridazinone and medicament for circulatory disease containing the same as an effective ingredient
GB9117340D0 (en) * 1991-08-10 1991-09-25 Fujisawa Pharmaceutical Co Dihydropyridine compounds,and process for their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
JPS60156671A (ja) * 1984-01-25 1985-08-16 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体およびその製造法

Also Published As

Publication number Publication date
PT82007A (en) 1986-03-01
FI860620A (fi) 1986-08-12
NO860464L (no) 1986-08-12
HUT40413A (en) 1986-12-28
GR860368B (en) 1986-05-29
ZA86815B (en) 1986-11-26
AU5326186A (en) 1986-08-14
JPS61233668A (ja) 1986-10-17
ES551845A0 (es) 1988-03-16
EP0194046A1 (en) 1986-09-10
PT82007B (en) 1987-12-22
DK65986D0 (da) 1986-02-11
DK65986A (da) 1986-08-12
FI860620A0 (fi) 1986-02-11
GB8503426D0 (en) 1985-03-13

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