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ES8207539A1 - Un procedimiento para la preparacion de un compuesto de pirimidoquinazolina. - Google Patents

Un procedimiento para la preparacion de un compuesto de pirimidoquinazolina.

Info

Publication number
ES8207539A1
ES8207539A1 ES507995A ES507995A ES8207539A1 ES 8207539 A1 ES8207539 A1 ES 8207539A1 ES 507995 A ES507995 A ES 507995A ES 507995 A ES507995 A ES 507995A ES 8207539 A1 ES8207539 A1 ES 8207539A1
Authority
ES
Spain
Prior art keywords
quinazoline derivatives
carboxy
chem
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507995A
Other languages
English (en)
Other versions
ES507995A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8207539A1 publication Critical patent/ES8207539A1/es
Publication of ES507995A0 publication Critical patent/ES507995A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE PIRIMIDOQUINAZOLINA Y SUS SALES FISIOLOGICAMENTE COMPATIBLE, DE FORMULA (I), EN LA QUE R1 ES CARBOXI ESTERIFICADO, Y A, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE CICLISACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R''1 ES CARBOXI ESTERIFICADO; A'' PUEDE SER VARIOS TIPOS DE REDICALES, Y R2 Y R3 POR CALENTAMIENTO A UNA TEMPERATURA ENTRE 160 Y 170 GRADOS CENTIGRADOS, EN PRESENCIA O AUSENCIA DE UN DISOLVENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIALERGICOS.
ES507995A 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de pirimidoquinazolina. Granted ES507995A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7941607 1979-12-03
GB8031965 1980-10-03

Publications (2)

Publication Number Publication Date
ES8207539A1 true ES8207539A1 (es) 1982-10-01
ES507995A0 ES507995A0 (es) 1982-10-01

Family

ID=26273769

Family Applications (4)

Application Number Title Priority Date Filing Date
ES497426A Expired ES8205202A1 (es) 1979-12-03 1980-12-03 Un procedimiento para preparar un compuesto de quinazolina
ES507995A Granted ES507995A0 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de pirimidoquinazolina.
ES507996A Granted ES507996A0 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de pirimidoquinazolina.
ES507994A Granted ES507994A0 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de quinazolina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES497426A Expired ES8205202A1 (es) 1979-12-03 1980-12-03 Un procedimiento para preparar un compuesto de quinazolina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES507996A Granted ES507996A0 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de pirimidoquinazolina.
ES507994A Granted ES507994A0 (es) 1979-12-03 1981-12-15 Un procedimiento para la preparacion de un compuesto de quinazolina.

Country Status (10)

Country Link
US (2) US4377580A (es)
EP (1) EP0030156B1 (es)
JP (1) JPH0651686B2 (es)
AT (1) ATE6778T1 (es)
AU (1) AU541811B2 (es)
DE (1) DE3067201D1 (es)
DK (1) DK513980A (es)
ES (4) ES8205202A1 (es)
GR (1) GR71637B (es)
IE (1) IE51802B1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3046366A1 (de) * 1980-12-09 1982-07-08 Bayer Ag, 5090 Leverkusen Tricyclische cytosinderivate zur verwendung in arzneimitteln und verfahren zu ihrer herstellung
JPS608274A (ja) * 1983-06-27 1985-01-17 Fujisawa Pharmaceut Co Ltd 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤
NO162019C (no) * 1983-11-23 1989-10-25 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
JP5236293B2 (ja) 2005-01-13 2013-07-17 ブリストル−マイヤーズ スクイブ カンパニー Ｘｉａ因子阻害剤としての置換ビアリール化合物
AU2013202912B2 (en) * 2007-06-08 2016-10-27 Firmenich Incorporated Modulation of chemosensory receptors and ligands associated therewith
US8633186B2 (en) * 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
CN102171197B (zh) 2008-07-31 2014-12-10 西诺米克斯公司 制备增甜剂的方法和中间体
MX2011001155A (es) 2008-07-31 2011-07-29 Senomyx Inc Composiciones que comprenden mejoradores del dulzor, y métodos para prepararlas.
WO2012021837A2 (en) 2010-08-12 2012-02-16 Senomyx, Inc. Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
CN104507933B (zh) 2012-05-31 2017-10-31 霍夫曼-拉罗奇有限公司 氨基喹唑啉和吡啶并嘧啶衍生物
RU2018129982A (ru) 2012-08-06 2019-03-15 Сеномикс, Инк. Модификатор сладкого вкуса и аромата
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
MX2021001193A (es) 2018-08-07 2021-04-28 Firmenich Incorporated 2,2-dioxidos de 4-amino-1h-benzo[c][1,2,6]tiadiazina 5-sustituidos y formulaciones y usos de los mismos.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1086666A (en) * 1966-09-12 1967-10-11 Wander Ag Dr A Novel 6-p-tolyl-2,3,6,7-tetrahydro-4h-pyrimido-[1,2-c] quinazoline
US3594379A (en) * 1968-09-16 1971-07-20 Sandoz Ag 2,3-dihydroimidazo(1,2-c)quinazolines
BE759842R (fr) 1969-12-05 1971-06-03 Sandoz Sa Nouveaux derives de la 4-amino-quinazoline, leur preparation etmedicaments contenant ces
CA986932A (en) * 1970-08-27 1976-04-06 Shigeho Inaba Process for preparing quinazoline derivatives
US4167569A (en) * 1976-12-09 1979-09-11 Imperial Chemical Industries Limited Pyrimido[1,2-a ]benzimidazole derivatives
US4105766A (en) * 1977-08-19 1978-08-08 Sterling Drug Inc. 4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acid derivatives
US4192944A (en) * 1978-04-03 1980-03-11 Bristol-Myers Company Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents

Also Published As

Publication number Publication date
ES8301234A1 (es) 1982-11-16
US4543356A (en) 1985-09-24
US4377580A (en) 1983-03-22
ATE6778T1 (de) 1984-04-15
IE802421L (en) 1981-06-03
ES8207540A1 (es) 1982-10-01
ES497426A0 (es) 1982-06-01
JPH0651686B2 (ja) 1994-07-06
DE3067201D1 (en) 1984-04-26
DK513980A (da) 1981-06-04
ES507994A0 (es) 1982-11-16
EP0030156B1 (en) 1984-03-21
IE51802B1 (en) 1987-04-01
ES8205202A1 (es) 1982-06-01
ES507995A0 (es) 1982-10-01
GR71637B (es) 1983-06-20
AU6473380A (en) 1981-06-11
AU541811B2 (en) 1985-01-24
ES507996A0 (es) 1982-10-01
JPH05294946A (ja) 1993-11-09
EP0030156A1 (en) 1981-06-10

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