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ES8801286A1 - Un procedimiento para preparar derivados de penem - Google Patents

Un procedimiento para preparar derivados de penem

Info

Publication number
ES8801286A1
ES8801286A1 ES556137A ES556137A ES8801286A1 ES 8801286 A1 ES8801286 A1 ES 8801286A1 ES 556137 A ES556137 A ES 556137A ES 556137 A ES556137 A ES 556137A ES 8801286 A1 ES8801286 A1 ES 8801286A1
Authority
ES
Spain
Prior art keywords
penem
derivatives
stability
cephalosporing
dehydropeptidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556137A
Other languages
English (en)
Other versions
ES556137A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of ES8801286A1 publication Critical patent/ES8801286A1/es
Publication of ES556137A0 publication Critical patent/ES556137A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pens And Brushes (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Materials For Medical Uses (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PENEM REPRESENTADOS POR LA FORMULA GENERAL (I). COMPRENDE LAS OPERACIONES DE HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R1 ES HIDROGENO, UN GRUPO ALQUILO O UN GRUPO HIDROXI-ALQUILO; R''2 REPRESENTA UN RESIDUO ESTER QUE PUEDE ACTUAR TAMBIEN SIMULTANEAMENTE COMO GRUPO PROTECTOR; Y R5 ES ALQUILO, ARILO O UN ARALQUILO, CON UN COMPUESTO DE TIOL REPRESENTADO POR LA FORMULA GENERAL (III), EN LA QUE R3 REPRESENTA UN GRUPO BICICLO-HETEROCICLICO SUSTITUIDO O NO, EN UN DISOLVENTE SELECCIONADO ENTRE N,N-DIMETILFORMAMIDA, DIMETILSULFOXIDO, TETRAHIDROFURANO Y HEXAMETILFOSFOTRIAMIDA, Y A UNA TEMPERATURA COMPRENDIDA ENTRE C50 GRADOS Y LA TEMPERATURA AMBIENTE. DE APLICACION COMO ANTIBIOTICOS EN EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS.
ES556137A 1985-06-17 1986-06-17 Un procedimiento para preparar derivados de penem Expired ES8801286A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13139485 1985-06-17
JP21342085 1985-09-26

Publications (2)

Publication Number Publication Date
ES8801286A1 true ES8801286A1 (es) 1988-01-01
ES556137A0 ES556137A0 (es) 1988-01-01

Family

ID=26466241

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556137A Expired ES8801286A1 (es) 1985-06-17 1986-06-17 Un procedimiento para preparar derivados de penem

Country Status (14)

Country Link
US (2) US4962202A (es)
EP (1) EP0210883B1 (es)
JP (2) JPH0826040B2 (es)
AT (1) ATE118007T1 (es)
AU (2) AU593558B2 (es)
CA (1) CA1339860C (es)
DE (1) DE3650221T2 (es)
DK (1) DK171644B1 (es)
ES (1) ES8801286A1 (es)
FI (1) FI87218C (es)
GR (1) GR861568B (es)
IE (1) IE67525B1 (es)
NO (1) NO167982C (es)
YU (1) YU46172B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339860C (en) * 1985-06-17 1998-05-12 Tsunehiko Soga Derivatives of penem
DK175069B1 (da) * 1986-03-11 2004-05-24 Hoffmann La Roche Pyrocatecholderivater
JP2579472B2 (ja) * 1986-12-17 1997-02-05 第一製薬株式会社 ペネム化合物
JP2708576B2 (ja) * 1988-11-08 1998-02-04 第一製薬株式会社 カルバペネム誘導体
US5541694A (en) * 1993-05-24 1996-07-30 Nikon Corporation Light shielding blade caulking pin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
US4650794A (en) * 1982-04-29 1987-03-17 Merck & Co., Inc. 6-(1-hydroxyethyl)-2-carbamimidoyl-pen-2-em-3-carboxylic acids
JPS58180490A (ja) * 1982-03-01 1983-10-21 メルク・エンド・カムパニ−・インコ−ポレ−テツド ６−置換−２−カルバムイミドイル−ペン−２−エム−３−カルボン酸
US4748162A (en) * 1982-03-01 1988-05-31 Merck & Co., Inc. 6-substituted-2-carbaminidoyl-pen-2-em-3-carboxylic acids
NO831160L (no) * 1982-04-08 1983-10-10 Erba Farmitalia Fremstilling av substituerte penem-derivater
ZA836966B (en) * 1982-09-28 1984-04-25 Bristol Myers Co Carbapenem antibiotics
ZA841781B (en) * 1983-03-14 1985-07-31 Schering Corp Penim compounds,methods for their preparation and pharmaceutical compositions containing them
US4772597A (en) * 1983-10-14 1988-09-20 Pfizer Inc. 2-azacycloalkylthiopenem derivatives
CA1273011A (en) * 1984-07-02 1990-08-21 Susan M. Schmitt Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
IE851586L (en) * 1984-07-02 1986-01-02 Interchem Internat S A I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
GB8509180D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
CA1339860C (en) * 1985-06-17 1998-05-12 Tsunehiko Soga Derivatives of penem
JP2579472B2 (ja) * 1986-12-17 1997-02-05 第一製薬株式会社 ペネム化合物

Also Published As

Publication number Publication date
US5079357A (en) 1992-01-07
DE3650221T2 (de) 1995-06-22
AU4478489A (en) 1990-03-08
IE861593L (en) 1986-12-17
FI87218C (fi) 1992-12-10
FI862566A (fi) 1986-12-18
DK283586A (da) 1986-12-18
JP2691678B2 (ja) 1997-12-17
EP0210883B1 (en) 1995-02-01
NO862411L (no) 1986-12-18
ATE118007T1 (de) 1995-02-15
CA1339860C (en) 1998-05-12
YU104986A (en) 1988-02-29
NO167982C (no) 1992-01-02
AU5890986A (en) 1986-12-24
US4962202A (en) 1990-10-09
FI862566A0 (fi) 1986-06-17
FI87218B (fi) 1992-08-31
JPH0826040B2 (ja) 1996-03-13
AU626606B2 (en) 1992-08-06
EP0210883A3 (en) 1987-07-01
YU46172B (sh) 1993-05-28
GR861568B (en) 1986-10-17
EP0210883A2 (en) 1987-02-04
AU593558B2 (en) 1990-02-15
DE3650221D1 (de) 1995-03-16
ES556137A0 (es) 1988-01-01
DK171644B1 (da) 1997-03-03
JPH06184146A (ja) 1994-07-05
DK283586D0 (da) 1986-06-17
JPS62149683A (ja) 1987-07-03
NO862411D0 (no) 1986-06-17
NO167982B (no) 1991-09-23
IE67525B1 (en) 1996-04-03

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